[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621616":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":29,"responsibleParty":48,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":10,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":74,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Ain Shams University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy Controls",null,"Age matched adults with no neurological disorders or gait impairments and normal MRI findings. Participants will undergo the same clinical, EEG, and MRI assessments as the patient group.",[13],"Other: No Intervention: Observational",{"label":15,"type":10,"description":16,"interventionNames":17},"SVD Patients","dults aged 50 years or older diagnosed with cerebral small vessel disease (SVD) showing gait disturbance confirmed by MRI (Fazekas score 2-3). Participants will undergo clinical assessment, EEG, and functional MRI.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"No Intervention: Observational","no intervention",[9,15],[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Hadeer Samir, Msc Neurology","CONTACT","+201011035548","Hadeer.samir@med.asu.edu.eg",[30],{"facility":31,"status":10,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Ain Shams University Hospitals","Cairo","Cairo Governorate","11566","Egypt","EG",{"type":38,"coordinates":39},"Point",[40,41],31.24967,30.06263,{"lat":41,"lon":40},[44],{"name":45,"role":26,"phone":46,"phoneExt":10,"email":47},"Hadeer Samir","01011035548","hadirsamir462@gmail.com",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Hadeer Samir Ahmed Hamada","Assistant lecturer of neurology, MD candidate , Ain Shams University","100621616","neural-correlates-eeg-and-fmri-of-gait-in-small-vessel-disease-100621616",false,"NCT07372937","Neural Correlates (EEG and fMRI) of Gait in Small Vessel Disease","Investigating Neural Correlates of Gait Abnormalities in Patients With Cerebral Small Vessel Disease","doesn't exist","Inclusion Criteria:\n\n* Age 50 years or older.\n* Clinical and radiological diagnosis of cerebral small vessel disease (SVD), confirmed by MRI findings such as white matter hyperintensities, lacunes, or microbleeds.\n* Fazekas score 2 or 3 on MRI.\n* Presence of slowly progressive gait disturbance (e.g., slowness, imbalance, freezing) rather than acute stroke presentation.\n\n  * Ability to give informed consent and cooperate with testing procedures.\n\nExclusion Criteria:\n\n* Presence of other neurodegenerative disorders (e.g., Parkinson's disease, Alzheimer's disease).\n* History of large vessel stroke or intracerebral hemorrhage.\n* Contraindications to MRI (e.g., pacemaker, metallic implants, severe claustrophobia).\n* Severe cognitive impairment that prevents participation (MoCA \\\u003C10).\n* Musculoskeletal or orthopedic causes of gait disturbance not related to neurological dysfunction.",true,"ALL","50 Years",{"count":64,"type":65},40,"ESTIMATED","OBSERVATIONAL","What is the purpose of this study? This observational study is being done to understand how cerebral small vessel disease (SVD) affects walking and balance. SVD is a common brain condition in older adults that damages small blood vessels. It can lead to problems with movement, thinking, and memory. The researchers want to find out how changes in brain activity and connectivity contribute to walking difficulties in people with SVD.\n\nWhy is this study important? Walking and balance problems increase the risk of falls and loss of independence. By studying brain activity during walking-related tasks, researchers hope to identify patterns that explain why these problems happen. This knowledge could help develop better rehabilitation methods in the future.\n\nWho can participate? Adults over 50 years old with cerebral small vessel disease and gradual gait problems may be eligible. Healthy adults of similar age without neurological problems may also take part as control participants.\n\nWhat will happen in this study?\n\nParticipants will:\n\nComplete walking, balance, and cognitive tests such as the Timed Up and Go, Berg Balance Scale, and Montreal Cognitive Assessment.\n\nUndergo brain imaging (MRI) to confirm the diagnosis and study brain structure and function.\n\nHave an EEG recording while resting and while watching short videos showing walking and turning movements.\n\nA smaller group will also undergo functional MRI (fMRI) while watching the same videos.\n\nThe MRI and EEG results will be analyzed to see how brain networks involved in movement and balance differ between patients and healthy adults.\n\nHow long will the study take? The study will take about two years to complete. Each participant's visit will last approximately two to three hours in total.\n\nWhat are the possible benefits? There may be no direct benefit to participants. However, this study may help researchers understand how small vessel disease affects brain function related to walking, which may improve care for future patients.",[69],"Cerebral Small Vessel Disease",[71,72,73],"Gait Disturbances, Vascular cognitive impairment","gait disturbances","vascular cognitive impairment","NOT_YET_RECRUITING","2026-01-31",{"date":77,"type":78},"2026-02-03","ACTUAL",{"date":80,"type":65},"2026-03-01",{"date":82,"type":65},"2027-03-01",{"name":5,"class":6},1]