[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100570023":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":45,"collaborators":20,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":20,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":67,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":59},{"fullName":5,"class":6},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients","EXPERIMENTAL","We will conduct a study using functional MRI and EEG in this subgroup of at least 1 patient(s) with a PRRT2 mutation capable of triggering paroxysmal dyskinesia episodes. We will analyze of the activation of regions involved in the occurrence of abnormal movements during the prodromal phase, during which the acquisition is not affected by movements. We will also investigate the regions involved in judging control over action during phases where abnormal movements may occur before and after the dyskinetic episode.\n\nThus, each subject will serve as their own control across different conditions of the experimental paradigm.",[13],"Behavioral: Voluntary and involuntary conditions",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Voluntary and involuntary conditions","An task fMRI\u002FEEG acquisition during the prodromal phase preceding the episode of abnormal movements.\n\nA task fMRI\u002FEEG acquisition the episode of abnormal movements A task fMRI\u002FEEG acquisition when the subject voluntary mimics the sequence of events (prdrosomal phase + episode of dyskinesia)",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Emmanuel Roze, MD, PhD","CONTACT","+33142162748","emmanuel.flamand-roze@psl.aphp.fr",[28],{"facility":29,"status":30,"city":31,"state":20,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"Institut du Cerveau de la Moelle Epinière ICM, Hôpital Pitié Salpêtrière,","RECRUITING","Paris","75651 PARIS cedex 13","France","FR",{"type":36,"coordinates":37},"Point",[38,39],2.3488,48.85341,{"lat":39,"lon":38},[42],{"name":43,"role":24,"phone":44,"phoneExt":20,"email":26},"Emmanuel FLAMAND ROZE","+33 1 42 16 27 48",{"type":46,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100570023","neural-correlates-of-movement-disorders-associated-with-prrt2-related-paroxysmal-kinesigenic-dyskinesia---an-ancillary-study-of-amedyst-research-100570023",false,"NCT06701851","Neural Correlates of Movement Disorders Associated With PRRT2 Related Paroxysmal Kinesigenic Dyskinesia - an Ancillary Study of AMEDYST Research","Corrélats Neuronaux Des Accès de Mouvements Anormaux Paroxystiques Liées Aux Dyskinésies Paroxystiques kinésigéniques Secondaires à Une Mutation du Gene PRRT2 - Recherche Ancillaire de L'étude AMEDYST \" Dont Vous êtes l'Investigateur Principal","TRIGGER","Inclusion Criteria:\n\nMale or female Individuals with dystonic disease carrying a PRRT2 mutation and demonstrating the ability to control paroxysmal dyskinesia episodes.\n\nAffiliated with a health insurance system or a beneficiary of such a system. Individuals aged 18 to 75 years. Signature of informed consent\n\nExclusion Criteria:\n\nIndividuals under guardianship. Individuals not residing in France. Individuals unable to comply with protocol constraints (compliance with visit schedules and ability to perform required tasks).\n\nIndividuals undergoing an exclusion period for another research study. Contraindications to MRI","ALL","18 Years","75 Years",{"count":59,"type":60},1,"ESTIMATED","INTERVENTIONAL",[63],"NA","The main objective of this study is to investigate in real-time the neuronal correlates of paroxysmal dyskinesia episodes related to the PRRT2 mutation within this subgroup of patients (who can control paroxysmal dyskinesia episodes), and more specifically, the pathological role of the reciprocal influence between the striatum and the cerebellum in paroxysmal dyskinesia episodes.",[66],"Paroxysmal Dyskinesia",[68,69,70,71,72,73,74],"dyskinesia","voluntary movements","cerebellum","basal ganglia","cortex","fMRI","EEG","2026-06-03",{"date":77,"type":78},"2026-06-05","ACTUAL",{"date":80,"type":78},"2025-01-21",{"date":82,"type":60},"2029-10",{"name":5,"class":6}]