[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614345":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":28,"locations":35,"responsibleParty":52,"collaborators":54,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":22,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":22,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":22,"overallStatus":38,"whyStopped":22,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Hugo W. Moser Research Institute at Kennedy Krieger, Inc.","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PASC Participants - Physical Fatigue Task","EXPERIMENTAL","Participants will perform a physically demanding task (grip force exertion task) repeatedly to induce physical fatigue.",[13],"Behavioral: Physical Fatigue",{"label":15,"type":10,"description":11,"interventionNames":16},"Control Participants - Physical Fatigue Task",[13],[18],{"type":19,"name":20,"description":11,"armGroupLabels":21,"otherNames":22},"BEHAVIORAL","Physical Fatigue",[15,9],null,[24],{"name":25,"affiliation":26,"role":27},"Vikram Chib, PhD","Johns Hopkins University; Kennedy Krieger Institute","PRINCIPAL_INVESTIGATOR",[29,34],{"name":30,"role":31,"phone":32,"phoneExt":22,"email":33},"Anthony Gonzalez","CONTACT","443-923-2716","gonzalezan@kennedykrieger.org",{"name":25,"role":31,"phone":22,"phoneExt":22,"email":22},[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Kennedy Krieger Institute","RECRUITING","Baltimore","Maryland","21201","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-76.61219,39.29038,{"lat":48,"lon":47},[51],{"name":30,"role":31,"phone":32,"phoneExt":22,"email":33},{"type":53,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[55],{"name":56,"class":57},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH","100614345","neural-mechanisms-of-fatigue-in-post-acute-sequela-of-sars-cov-2-100614345",false,"NCT07278388","Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2","Motivated Decision-Making and Performance","Inclusion Criteria:\n\n* Age 18 to 75 years old.\n* Have received a clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)\u002Flong COVID syndrome using the criteria specified by Thaweethai, et al., 2023 (JAMA). This symptom checklist provides a score based on the number and severity of symptoms. An individual with a score \\>12 is classified as having PASC.\n* Currently experiencing Fatigue\u002FBrain Fog as assessed with the Post-COVID symptom checklist and the PedsQL questionnaire.\n\nExclusion Criteria:\n\n* Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).\n* Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).\n* Congestive heart failure.\n* Peripheral artery disease with claudication.\n* Cancer.\n* Pulmonary or renal failure.\n* Unstable angina.\n* Uncontrolled hypertension (more than 190\u002F110 mmHg).\n* Severe aphasia.\n* Orthopedic or pain conditions.\n* Have had exposure to metal or metal implants, due to the hazardous effects of the magnetic field.\n* If on immunomodulatory therapy, they must have been on that therapy for at least 6 months before the start of the study.\n\nHealthy age- and sex-matched controls for PASC - Exclusion criteria: Participants with a history of any of the following will be excluded from the study:\n\n* Hospitalization due to SARS-CoV-2 infection.\n* Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).\n* Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).\n* Congestive heart failure.\n* Peripheral artery disease with claudication.",true,"ALL","18 Years","75 Years",{"count":70,"type":71},200,"ESTIMATED","INTERVENTIONAL",[74],"NA","This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.",[77,78],"PASC Post Acute Sequelae of COVID 19","Fatigue","2025-12-01",{"date":81,"type":82},"2025-12-12","ACTUAL",{"date":84,"type":82},"2025-07-16",{"date":86,"type":71},"2029-12-31",{"name":5,"class":6},1]