[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591412":3},{"organization":4,"armGroups":7,"interventions":39,"overallOfficials":45,"centralContacts":66,"locations":72,"responsibleParty":94,"collaborators":45,"id":98,"slug":99,"hasResults":100,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":45,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":105,"minAge":106,"maxAge":107,"enrollmentInfo":108,"targetDuration":45,"studyType":111,"phases":112,"briefSummary":114,"conditions":115,"keywords":120,"overallStatus":75,"whyStopped":45,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":134},{"fullName":5,"class":6},"Trustees of Dartmouth College","OTHER",[8,17,21,25,29,35],{"label":9,"type":10,"description":11,"interventionNames":12},"Experiment 1 - Crossover Order: Session A-B-D-C","EXPERIMENTAL","Participants complete all four experimental sessions in the following sequence: 1. Session A; 2. Session B; 3. Session D; 4. Session C",[13,14,15,16],"Behavioral: Session A: Positive Placebo + Active tTIS","Behavioral: Session B: Positive Placebo + Sham tTIS","Behavioral: Session C: Negative Placebo + Active tTIS","Behavioral: Session D: Negative Placebo + Sham tTIS",{"label":18,"type":10,"description":19,"interventionNames":20},"Experiment 1- Crossover Order: Session B-C-A-D","Participants complete all four experimental sessions in the following sequence: 1. Session B; 2. Session C; 3. Session A; 4. Session D",[13,14,15,16],{"label":22,"type":10,"description":23,"interventionNames":24},"Experiment 1- Crossover Order: Session C-D-B-A","Participants complete all four experimental sessions in the following sequence: 1. Session C; 2.Session D; 3. Session B; 4. Session A",[13,14,15,16],{"label":26,"type":10,"description":27,"interventionNames":28},"Experiment 1- Crossover Order: Session D-A-C-B","Participants complete all four experimental sessions in the following sequence: 1. Session D; 2. Session A; 3. Session C; 4. Session B",[13,14,15,16],{"label":30,"type":10,"description":31,"interventionNames":32},"Experiment 2 - Crossover Order : Session E-F","Participants complete all two experimental sessions in the following sequence: 1. Session E; 2. Session F",[33,34],"Behavioral: Session E: On-Placebo + Sham tTIS","Behavioral: Session F: Off-Placebo + Sham tTIS",{"label":36,"type":10,"description":37,"interventionNames":38},"Experiment 2 - Crossover Order : Session F-E","Participants complete all two experimental sessions in the following sequence: 1. Session F; 2. Session E",[33,34],[40,46,50,54,58,62],{"type":41,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"BEHAVIORAL","Session A: Positive Placebo + Active tTIS","Participants receive active tTIS with two channels set at 2000 Hz and 2010 Hz, creating a 10 Hz interference beat targeting the anterior\u002Fmid-cingulate cortex (aMCC). Stimulation is delivered at 2 mA per channel for 20 minutes. The stimulation is combined with a positive social placebo intervention delivered by the care provider. Participants complete three multimodal negative affect tasks (MNAT) before and after the stimulation.",[9,18,22,26],null,{"type":41,"name":47,"description":48,"armGroupLabels":49,"otherNames":45},"Session B: Positive Placebo + Sham tTIS","Participants receive sham tTIS (brief 80-second stimulation followed by no current) paired with a positive social placebo intervention. The device mimics active parameters (2 mA per channel, 20 minutes) without delivering effective stimulation. The sham stimulation is paired with a positive social placebo intervention. Participants complete three MNAT tasks before and after the session.",[9,18,22,26],{"type":41,"name":51,"description":52,"armGroupLabels":53,"otherNames":45},"Session C: Negative Placebo + Active tTIS","Participants receive active tTIS (2000 Hz and 2010 Hz signals, 2 mA per channel, 20 minutes) combined with a negative social placebo intervention (neutral or skeptical messaging about treatment efficacy). Participants complete three MNAT tasks before and after the stimulation.",[9,18,22,26],{"type":41,"name":55,"description":56,"armGroupLabels":57,"otherNames":45},"Session D: Negative Placebo + Sham tTIS","Participants receive sham tTIS (brief 80-second stimulation followed by no current) combined with a negative social placebo intervention. Participants complete three MNAT tasks before and after the session.",[9,18,22,26],{"type":41,"name":59,"description":60,"armGroupLabels":61,"otherNames":45},"Session E: On-Placebo + Sham tTIS","Participants receive sham tTIS (brief 15-second stimulation followed by no current) paired with a positive social placebo intervention. Participants complete three MNAT tasks before and after the session.",[30,36],{"type":41,"name":63,"description":64,"armGroupLabels":65,"otherNames":45},"Session F: Off-Placebo + Sham tTIS","Participants receive sham tTIS (brief 15-second stimulation, then no current) without any placebo intervention. Participants complete three MNAT tasks before and after the session.",[30,36],[67],{"name":68,"role":69,"phone":70,"phoneExt":45,"email":71},"Zhaoxing Wei, Ph.D.","CONTACT","6033220577","zhaoxing.wei@dartmouth.edu",[73],{"facility":74,"status":75,"city":76,"state":77,"zip":78,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":86,"contacts":87},"Dartmouth College, Department of Psychological and Brain Sciences","RECRUITING","Hanover","New Hampshire","03755","United States","US",{"type":82,"coordinates":83},"Point",[84,85],-72.28954,43.70229,{"lat":85,"lon":84},[88,92],{"name":89,"role":69,"phone":90,"phoneExt":45,"email":91},"Tor D. Wager, Ph.D.","603-646-2196","tor.d.wager@dartmouth.edu",{"name":68,"role":93,"phone":45,"phoneExt":45,"email":45},"SUB_INVESTIGATOR",{"type":95,"investigatorFullName":96,"investigatorTitle":97,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"PRINCIPAL_INVESTIGATOR","Tor Wager","Diana L. Taylor Distinguished Professor","100591412","neural-mechanisms-of-interpersonal-expectations-on-negative-affect-100591412",false,"NCT06980090","Neural Mechanisms of Interpersonal Expectations on Negative Affect","Inclusion Criteria:\n\n'Doctors' are recruited from medical students at the Geisel School of Medicine and resident physicians at Dartmouth Hitchcock Medical Center (DHMC).\n\nExclusion Criteria:\n\n* No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis\n* No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment\n* No self-reported current chronic pain, or acute pain within three months of the study period\n* No current migraine disorder (i.e., 15 headache days or more in 1 month)\n* No use of central nervous system-effective medication or other medication for neurological\u002Fpsychiatric treatment\n* No self-reported substance abuse within the last six months\n* No contraindication to MRI or tTIS (e.g., pregnancy, claustrophobia, pacemakers, ear\u002Fcochlear implants, shrapnel injuries, clips, or other ferromagnetic\u002Felectrical objects\u002Fdevices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)\n* No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)\n* Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English\n* Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)",true,"ALL","18 Years","55 Years",{"count":109,"type":110},196,"ESTIMATED","INTERVENTIONAL",[113],"NA","The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence these effects.\n\nThe main questions this study aims to answer are: (1)Does active tTIS reduce negative affect more effectively than sham (inactive) tTIS? (2)Do positive treatment expectations enhance the effects compared to negative expectations?\n\nParticipants will: (1) Receive either active or sham tTIS. (2) Be provided with positive or negative messaging regarding treatment effectiveness. (3) Interact with care providers and complete assessments measuring negative affect and physiological responses.",[116,117,118,119],"Negative Affectivity","Non-invasive Brain Stimulation","Placebo Effect","Expectations",[121,122,123,124],"Transcranial temporal interference stimulation","Pain","Fear","Cognitive effort","2026-06-08",{"date":127,"type":128},"2026-06-11","ACTUAL",{"date":130,"type":128},"2025-09-01",{"date":132,"type":110},"2028-03-03",{"name":5,"class":6},1]