[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611801":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":35,"centralContacts":39,"locations":44,"responsibleParty":62,"collaborators":64,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":22,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":22,"enrollmentInfo":77,"targetDuration":22,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":88,"overallStatus":47,"whyStopped":22,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of North Carolina, Chapel Hill","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Light sequence during imaging","EXPERIMENTAL","The sequence of stimulus presentation for resting state scans will be Equal Energy White (with luminance modulation) for 8 minutes then Static Green for 8 minutes, followed by an anatomical scan, then S-cone modulating stimuli for 8 minutes.",[13,14,15,16],"Other: S-cone modulating visual stimulus","Other: Equal Energy White Visual Stimulus","Other: Green light visual stimulus (S-OFF)","Other: Evoked Pressure Pain Stimulus",[18,23,27,31],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"S-cone modulating visual stimulus","The investigators will deliver a uniform wide-field, S-cone modulating stimulus via a fiberoptic, MRI-safe visual stimulator. This stimulus approximates the appearance of white but modulates the S-cone, driving the S-ON and S-OFF pathways by alternating two lights at 19 Hz using a mixture of light emitting diodes (LEDs), including those embedded in our stimulus with spectral peaks of 405, 565, and 660 nm. This stimulus will differentially activate the S-cones where, between the two phases the ratio of S-cone activity is 100. The frequency alternating between the two lights, 19 Hz, was chosen because retinal ganglion cells in the retina still respond robustly but above the cortical perceptual flicker detection threshold.",[9],null,{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"Equal Energy White Visual Stimulus","The investigators will deliver a uniform wide-field, equal-energy light stimulus via a fiberoptic, MRI-safe visual stimulator. This will serve as a reference condition in which chromatic opponency has been eliminated. This stimulus ensures that the quantal catch of each cone photoreceptor (S-, M- and L-) is held constant using a mixture of LEDs, including those embedded in our stimulus with spectral peaks of 405, 565, and 660 nm. The stimulus will modulate to nearly approximate the appearance of the S-cone modulating light.",[9],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"Green light visual stimulus (S-OFF)","The investigators will deliver a uniform wide-field, green light modulating stimulus via a fiberoptic, MRI-safe visual stimulator. Static Green (565 nm) Light presented via MRI compatible light guides.",[9],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":22},"Evoked Pressure Pain Stimulus","The pressure in which a rapid inflation cuff positioned over the left gastrocnemius achieves a pain severity of 40 where 0 is \"no pain\" and 100 is the \"worst pain imaginable will be determined pre-scan and applied during the entire functional imaging acquisition to evoke a deep pressure pain.",[9],[36],{"name":37,"affiliation":5,"role":38},"Matthew Mauck, MD, PhD","PRINCIPAL_INVESTIGATOR",[40],{"name":37,"role":41,"phone":42,"phoneExt":22,"email":43},"CONTACT","919-966-5136","matt_mauck@med.unc.edu",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"University of North Carolina at Chapel Hill","RECRUITING","Chapel Hill","North Carolina","27599","United States","US",{"type":54,"coordinates":55},"Point",[56,57],-79.05584,35.9132,{"lat":57,"lon":56},[60,61],{"name":37,"role":41,"phone":42,"phoneExt":22,"email":43},{"name":37,"role":38,"phone":22,"phoneExt":22,"email":22},{"type":63,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR",[65],{"name":66,"class":67},"National Institute of Neurological Disorders and Stroke (NINDS)","NIH","100611801","neural-mechanisms-of-light-driven-analgesia-100611801",false,"NCT07245303","Neural Mechanisms of Light Driven Analgesia","Inclusion Criteria for participants with cMSP and healthy controls (n=30)\n\n* Adults ≥18 years of age.\n* Individuals who do not have any plans for medication or treatment changes for the next 3 months.\n* Participants must be willing and able to undergo an MRI.\n* Participants must not be claustrophobic\n* Participants must be alert and oriented and able to provide informed consent.\n* Individuals must be able to speak and read English.\n\nInclusion Criteria for participants with cMSP only (n=30)\n\n* To be eligible, participants must have a score of ≥7 on the Widespread pain index (WPI) and ≥5 on the symptom severity scale (SSS), or 4-6 on the WPI and ≥9 on the SSS in the 2016 Fibromyalgia Questionnaire.\n* Pain symptoms must have been present for 3 months or longer.\n* Pain must be present in 4 out of 5 body regions.\n* Individuals enrolled will have an average pain severity ≥4 on the 0-10 NRS over the month prior to enrollment to recruit individuals with moderate to severe chronic MSP.\n\nInclusion Criteria for Participants with Congenital Stationary Night Blindness (n=2)\n\n-2 additional participants without chronic MSP will be recruited with diagnosed congenital stationary night blindness\n\nExclusion Criteria:\n\n* Presence of retinal vision disorders or conditions resulting in vision impairment.\n* Patient-reported photosensitivity, photophobia, or aversion (as may occur in autoimmune diseases such as systematic lupus erythematosus).\n* Disorders including uveitis, cataracts, color-blindness, history of seizure disorder.\n* Plans for analgesic treatment plan changes in next 3 months (surgery, analgesic medication changes, injections, pain procedures, etc).\n* Prisoner Status.\n* Pregnancy.\n* Contraindications to MRI imaging. These include the presence of implanted\u002Fembedded ferromagnetic materials, implanted medical devices that are not MRI compatible, and claustrophobia.",true,"ALL","18 Years",{"count":78,"type":79},60,"ESTIMATED","INTERVENTIONAL",[82],"NA","The goal of this study will be to understand the biological mechanisms that are responsible to light-driven analgesia. Light presented to the retina has been shown to have pain relieving properties in pre-clinical and clinical studies. In this study the investigators will evaluate the functional connectivity between subcortical visual areas and non-image forming brain areas that are involved in pain sensation. The investigators will also evaluate how three colored light stimuli presented to the retina results in changes in whole brain evoked activation patterns in participants with chronic musculoskeletal pain and in healthy controls. The investigators will also assess while brain evoked activation patterns in response to a pressure pain stimulus in the presence of three light stimuli in individuals with chronic musculoskeletal pain and healthy controls.",[85,86,87],"Musculoskeletal Pain","Fibromyalgia","Healthy Controls Group - Age and Sex-matched",[89,90,91,92],"functional connectivity","colored light analgesia","functional magnetic resonance imaging","quantitative sensory testing","2026-05-08",{"date":95,"type":96},"2026-05-13","ACTUAL",{"date":98,"type":96},"2026-02-24",{"date":100,"type":79},"2030-01-31",{"name":5,"class":6},1]