[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100468234":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":37,"locations":45,"responsibleParty":68,"collaborators":26,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":26,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":48,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University of Wisconsin, Milwaukee","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Response Inhibition Training (RIT)","EXPERIMENTAL","Response Inhibition Training (RIT) is a about 40-level computer game designed to offer systematic practice of RI. Participants use the computer keyboard and mouse to respond to the demands of trials that are designed to offer training on response inhibition abilities, including suppressing pre-potent but irrelevant stimuli and responses. Each training session will last approximately 45 minutes. All participants will be offered a minimum of 8 sessions. Throughout training, we will continually monitor their behavioral RI index (= stop signal reaction time; SSRT) using a stop-signal task. If a participant's Index SSRT fails to reach a criterion-level reduction (i.e., approximately 1 SD) after the standard 8 session intervention, the RIT intervention will be extended up to 16 sessions until the criterion-level improvement in behavioral RI is attained.",[13],"Behavioral: Computerized cognitive training",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Training (PLT)","PLACEBO_COMPARATOR","This training condition is designed to serve as an appropriate control condition for RIT, by providing no active ingredient of RI training components, while maintaining the overall training materials and structure similar. Similar to RIT, PLT uses the same task materials and a similar 40-level game structure. However, PLT will present simple RI-irrelevant visual judgment tasks to avoid changing RI-relate processes. The number of 45-min training sessions will be determined by their counterpart RIT participants through a yoked-control design.",[19],"Behavioral: Computerized placebo training",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Computerized cognitive training","This intervention offers 45-minute computerized training sessions to each participant. This intervention aims to improve the individual's RI capabilities. All participants will receive 8 to 16 sessions after being randomized to this condition.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Computerized placebo training","This intervention offers 45-minute computerized placebo cognitive training sessions to each participant. This intervention aims to exert no focused training on RI capabilities. All participants will receive 8 to 16 sessions after being randomized to this condition.",[15],[32,35],{"name":33,"affiliation":5,"role":34},"Hanjoo Lee, Ph.D.","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":34},"Christine Larson, Ph.D.",[38,42],{"name":33,"role":39,"phone":40,"phoneExt":26,"email":41},"CONTACT","414-229-5858","leehj@uwm.edu",{"name":36,"role":39,"phone":43,"phoneExt":26,"email":44},"414-229-4996","larsoncl@uwm.edu",[46],{"facility":47,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"UWM Anxiety Disorders Laboratory","RECRUITING","Milwaukee","Wisconsin","53211","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-87.90647,43.0389,{"lat":58,"lon":57},[61,65,66,67],{"name":62,"role":39,"phone":63,"phoneExt":26,"email":64},"Halle Berres, B.A.","262-364-6249","ocd-research@uwm.edu",{"name":33,"role":39,"phone":40,"phoneExt":26,"email":41},{"name":33,"role":39,"phone":26,"phoneExt":26,"email":26},{"name":36,"role":39,"phone":26,"phoneExt":26,"email":26},{"type":69,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100468234","neural-mechanisms-of-response-inhibition-training-for-ocrd-100468234",false,"NCT05377125","Neural Mechanisms of Response Inhibition Training for OCRD","Neural Mechanisms of Response Inhibition Training for Obsessive-Compulsive Disorder and Related Conditions","OCRD","Inclusion Criteria:\n\n* age between 18 and 60\n* moderate level of OCRD symptoms (Yale-Brown Obsessive Compulsive Scale total ≥ 16, Massachusetts General Hospital-Hair pulling Scale total ≥ 12, or Skin Picking Scale-Revised total ≥ 7)\n* a primary diagnosis of OCRD (i.e., OCD, TTM, or SPD)\n* estimated IQ \\> 80\n* presence of a RI deficits (SSRT ≥ 215ms).\n\nExclusion Criteria:\n\n* Current substance use disorder\n* Severe ADHD\n* Lifetime diagnosis of psychotic disorder, bipolar disorder, or schizophrenia\n* Current psychotherapy\n* Change in psychotropic medication status within 8 weeks before the study or during the study\n* Use of stimulant medication\n* Active suicidal risk\n* Contraindications for MRI procedures","ALL","18 Years","60 Years",{"count":82,"type":83},118,"ESTIMATED","INTERVENTIONAL",[86],"NA","The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. There is a critical need to develop an effective and durable treatment for OCRDs with demonstrable evidence for improving impaired RI. The purpose of our project is to examine the impact of a novel computerized intervention, response inhibition training (RIT), on neural indices of RI, and examine the mechanistic link between engagement of the neural RI targets and change in OCRD symptoms. To this end, this project will conduct a randomized clinical trial for individuals with OCD, trichotillomania, and\u002For skin picking disorders. Participants will be randomly assigned to 8 to 16 sessions of computerized RIT or a computerized placebo training. Various clinical, behavioral, and brain-imaging data will be acquired to evaluate the training effects at baseline, post-training, and 1-month follow-up periods.",[89,90,91],"Obsessive-Compulsive Disorder","Tricholemmoma","Skin-Picking",[93],"OCD; Trichotillomania; Excoriation; Response Inhibition","2024-07-17",{"date":96,"type":97},"2024-07-19","ACTUAL",{"date":99,"type":97},"2022-12-22",{"date":101,"type":83},"2027-08",{"name":5,"class":6},1]