[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629879":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":32,"responsibleParty":45,"collaborators":25,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":25,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":25,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":75,"whyStopped":25,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Shanghai Mental Health Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"online group","EXPERIMENTAL","The on-line group will watch body-focused sensory videos during each rTMS session.",[13],"Device: repetitive transcranial magnetic stimulation (rTMS)",{"label":15,"type":16,"description":17,"interventionNames":18},"off-line group","ACTIVE_COMPARATOR","The off-line group will remain at rest during each rTMS sessions.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","repetitive transcranial magnetic stimulation (rTMS)","Repetitive transcranial magnetic stimulation (rTMS) will be delivered at 1 Hz with a total of 1,200 pulses per session, administered five times per day for six consecutive days. Target localization will be based on each participant's T1-weighted structural MRI, using a neuronavigation system to establish an individualized head model and identify the Supplementary Motor Area. The stimulation intensity will be set at 110% of the individual resting motor threshold (RMT).",[15,9],null,[27],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Jiayue Cheng, Master","CONTACT","+8602134773503","chengjy_94@163.com",[33],{"facility":5,"status":25,"city":34,"state":25,"zip":25,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Shanghai","China","CN",{"type":38,"coordinates":39},"Point",[40,41],121.45806,31.22222,{"lat":41,"lon":40},[44],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},{"type":46,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Jiayue CHENG","Principal Investigator","100629879","neural-mechanisms-of-the-sensorymotor-circuit-in-sensory-phenomena-in-ocd-100629879",false,"NCT07480408","Neural Mechanisms of the Sensorymotor Circuit in Sensory Phenomena in OCD","Neural Mechanisms of the Insula-Supplementary Motor Area Circuit in Sensory Phenomena in Obsessive-Compulsive Disorder","Inclusion Criteria:\n\nOCD with abnormal sensory phenomena\n\n1. Meet the diagnostic criteria for Obsessive-Compulsive Disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition.\n2. Aged 18-55 years.\n3. Score ≥16 on the Yale-Brown Obsessive Compulsive Scale, indicating moderate to severe symptoms.\n4. Score \\>6 on the Sensory Phenomena Scale (SPS), indicating moderate to severe sensory phenomena.\n5. Right-handed.\n6. Either medication-free or on stable medication for at least 8 weeks.\n\nOCD without abnormal sensory phenomena\n\n1. Meet the diagnostic criteria for Obsessive-Compulsive Disorder according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition.\n2. Aged 18-55 years.\n3. Score ≥16 on the Yale-Brown Obsessive Compulsive Scale.\n4. Score ≤6 on the Sensory Phenomena Scale (SPS).\n5. Right-handed.\n6. Either medication-free or on stable medication for at least 8 weeks.\n\nExclusion criteria\n\n1. Meeting diagnostic criteria in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition for psychiatric disorders other than OCD or obsessive-compulsive personality disorder.\n2. OCD symptoms so severe that required assessments cannot be completed.\n3. Presence of severe suicidal ideation or high suicide risk.\n4. Pregnant women or women planning pregnancy in the near future.\n5. History of epilepsy or any medical condition that may induce seizures or intracranial hypertension.\n6. Contraindications to MRI, such as metallic implants.\n7. Clinically significant medical illnesses or abnormal laboratory findings.\n8. Inability to complete study procedures due to severe symptoms, low cognitive functioning, or poor cooperation.\n\nHealthy Controls Inclusion criteria\n\n1. No current or past psychiatric disorders meeting diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition.\n2. Aged 18-55 years.\n3. Right-handed. Exclusion criteria\n\n1\\. Pregnant women or women planning pregnancy in the near future. 2. History of epilepsy or any medical condition that may induce seizures or intracranial hypertension.\n\n3\\. Presence of severe suicidal ideation or high suicide risk. 4. Contraindications to MRI, such as metallic implants. 5. Clinically significant medical illnesses or abnormal laboratory findings. 6. Inability to complete study procedures due to severe symptoms, low cognitive functioning, or poor cooperation.",true,"ALL","18 Years","55 Years",{"count":61,"type":62},120,"ESTIMATED","INTERVENTIONAL",[65],"NA","The goal of this clinical study is to investigate the neural mechanisms of abnormal sensory phenomena in patients with Obsessive-Compulsive Disorder and to evaluate whether modulation of the insula-supplementary motor area circuit can improve these symptoms. The study will include adult patients with OCD (with or without sensory phenomena) and healthy volunteers.\n\nThe main questions it aims to answer are:\n\n* Do patients with OCD show abnormal activity in the insula-SMA circuit compared with healthy controls?\n* Is this abnormality associated with the presence and severity of abnormal sensory phenomena?\n* Can low-frequency rTMS targeting the Supplementary Motor Area improve sensory phenomena and obsessive-compulsive symptoms? Researchers will compare an on-line rTMS group (viewing body-focused videos during stimulation) with an off-line rTMS group (resting during stimulation) to evaluate whether task engagement enhances treatment effects.\n\nParticipants will:\n\n* Complete clinical assessments and behavioral tasks.\n* Undergo EEG and fMRI assessments.\n* Receive low-frequency rTMS targeting the Supplementary Motor Area.\n* Repeat assessments after the intervention.",[68],"Obsessive - Compulsive Disorder",[70,71,72,73,74],"obsessive-compulsive disorder","sensory phenomena","supplementary motor area","insula","neuromodulation","NOT_YET_RECRUITING","2026-03-18",{"date":78,"type":79},"2026-03-20","ACTUAL",{"date":81,"type":62},"2026-05-01",{"date":83,"type":62},"2028-12-31",{"name":5,"class":6},1]