[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100494023":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":42,"responsibleParty":67,"collaborators":70,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":78,"acronym":24,"eligibilityCriteria":79,"healthyVolunteers":76,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":24,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":24,"overallStatus":45,"whyStopped":24,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Blue then Red Light","EXPERIMENTAL","Blue light (480 nm) then Red light (640 nm)",[13,14],"Other: Blue Light","Other: Red Light",{"label":16,"type":10,"description":17,"interventionNames":18},"Red Light then Blue Light","Red light (640 nm) then Blue light (480 nm)",[13,14],[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Blue Light","Blue light exposure",[9,16],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Red Light","Red light exposure",[9,16],[30],{"name":31,"affiliation":5,"role":32},"Adriane M Soehner, PhD","PRINCIPAL_INVESTIGATOR",[34,38],{"name":31,"role":35,"phone":36,"phoneExt":24,"email":37},"CONTACT","4122466651","soehneram2@upmc.edu",{"name":39,"role":35,"phone":40,"phoneExt":24,"email":41},"Allison Caswell, BS","4122466652","caswella@upmc.edu",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Western Psychiatric Hospital","RECRUITING","Pittsburgh","Pennsylvania","15213","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-79.99589,40.44062,{"lat":55,"lon":54},[58,61,62,65],{"name":59,"role":35,"phone":60,"phoneExt":24,"email":41},"Allison Caswell","412-246-6652",{"name":31,"role":32,"phone":24,"phoneExt":24,"email":24},{"name":63,"role":64,"phone":24,"phoneExt":24,"email":24},"Henry Chase, PhD","SUB_INVESTIGATOR",{"name":66,"role":64,"phone":24,"phoneExt":24,"email":24},"Kathryn Roecklein, PhD",{"type":32,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Adriane Soehner","Assistant Professor",[71],{"name":72,"class":73},"National Institute of Mental Health (NIMH)","NIH","100494023","neuro-affective-response-to-light-in-depressed-adolescents-and-young-adults-100494023",false,"NCT05712772","Neuro-affective Response to Light in Depressed Adolescents and Young Adults","Inclusion Criteria:\n\n* Elevated Depressive Symptoms \\[PHQ9≥5 And (Item 1≥1 or Item 2≥1)\\]\n* (If \\\u003C18yr) Parent or guardian can attend the baseline clinical interview\n\nExclusion Criteria:\n\n* Unable to read and write in English\n* Intellectual disability.\n* Left or mixed handedness\n* Changes to psychotropic medication type or dosage in the past 2 months\n* Lifetime bipolar disorder or schizophrenia, or substance\u002Falcohol disorder in the past 3 months.\n* Factors influencing light and color sensitivity (i.e., color-blindness, serious ophthalmological conditions, photo-sensitizing medication).\n* Factors influencing the ability to maintain a stable sleep schedule (i.e., shift work, severe sleep disorders, extremely late or early sleep schedule).\n* Severe medical illness, neurological disorders, or history of head trauma.\n* Current pregnancy or nursing\n* MRI contraindication (e.g., metals in the body, recent tattoo, claustrophobia)\n* Positive alcohol or substance use screen at MRI visit","ALL","12 Years","30 Years",{"count":84,"type":85},80,"ESTIMATED","INTERVENTIONAL",[88],"NA","The goal of this neuroimaging pilot study is to understand developmental differences in the impact of therapeutic wavelength light (blue light) versus a non-therapeutic wavelength (red light) on emotional brain function in depression. The main questions this study aims to answer are:\n\n* Does acute exposure to blue light (vs red light) stabilize emotional brain function in depressed individuals?\n* Are stabilizing effects of blue light (vs red light) stronger for blue light in adolescents than young adults?\n\nParticipants will complete:\n\n* A magnetic resonance imaging brain scan, in which we will examine the effect of blue versus red light on emotional brain function at rest and in response to rewards and losses.\n* A pupillometry test of sensitivity to blue vs red light\n* Clinical interviews and surveys\n* Screening measures for drug and alcohol use, MRI safety, and current pregnancy \\[if relevant\\]\n* Home sleep tracking with sleep diary and actigraphy for one week",[91,92],"Depression in Adolescence","Depression in Adults","2025-08-05",{"date":95,"type":96},"2025-08-11","ACTUAL",{"date":98,"type":96},"2023-06-14",{"date":100,"type":85},"2026-07-31",{"name":5,"class":6},1]