[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100434706":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":50,"collaborators":53,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":19,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":19,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":19,"overallStatus":31,"whyStopped":19,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Ecological Momentary Assessment","EMA collected daily (4x\u002Fday) for two weeks",[12],"Behavioral: EMA",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"BEHAVIORAL","EMA","Participants will complete surveys about their feelings and social habits through a smartphone app (EMA)",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Daphne J Holt, MD, PhD","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},"CONTACT","617-726-7618","dholt@partners.org",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Charlestown","Massachusetts","02129","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-71.062,42.37787,{"lat":41,"lon":40},[44,46],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":45},"dholt@mgh.harvard.edu",{"name":47,"role":26,"phone":48,"phoneExt":19,"email":49},"Nicole DeTore, PhD","617-726-2065","ndetore@mgh.harvard.edu",{"type":23,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Daphne Holt","Associate Professor of Psychiatry",[54],{"name":55,"class":6},"Boston University","100434706","neurobehavioral-mechanisms-of-social-isolation-and-loneliness-in-serious-mental-illness-100434706",false,"NCT04940663","Neurobehavioral Mechanisms of Social Isolation and Loneliness in Serious Mental Illness","Inclusion Criteria:\n\n1. 18-55 years old\n2. Experienced a psychotic disorder or mood disorder\n\nExclusion Criteria:\n\n1. Any neurological disorder or current substance use disorder (during the past 6 months)\n2. Not proficient in English\n3. A recent change in medication, or an acute symptom presentation\n4. Standard exclusion criteria for participation in an MRI scan (e.g., presence of metal in the body, claustrophobia, a history of head trauma).",true,"ALL","18 Years","55 Years",{"count":67,"type":68},120,"ESTIMATED","INTERVENTIONAL",[71],"NA","The proposed research will test the hypothesis that objective social isolation and loneliness are linked to neurobehavioral mechanisms involved in social perception and motivation in individuals with and without serious mental illness. Moreover, it will investigate the specific dynamic interactions among these experiences in daily life and how they, and their neurobehavioral predictors, are linked to day-to-day functioning. The findings of this project could provide novel targets for therapeutics aimed at improving functioning and overall quality of life in individuals with serious mental illnesses, as well as quantitative phenotypes for use in early detection efforts.",[74,75],"Psychosis","Schizophrenia","2026-05-07",{"date":78,"type":79},"2026-05-11","ACTUAL",{"date":81,"type":79},"2022-07-13",{"date":83,"type":68},"2026-06",{"name":5,"class":6},1]