[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100557646":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":10,"centralContacts":22,"locations":10,"responsibleParty":31,"collaborators":35,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":10,"eligibilityCriteria":47,"healthyVolunteers":44,"sex":48,"minAge":49,"maxAge":10,"enrollmentInfo":50,"targetDuration":10,"studyType":53,"phases":10,"briefSummary":54,"conditions":55,"keywords":10,"overallStatus":59,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":10},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"patients with pituitary disorders",null,[12],"Diagnostic Test: Dexa or Biompedance analysis with clinical and biochemical evaluations",{"label":14,"type":10,"description":10,"interventionNames":15},"patients without pituitary disorders",[12],[17],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":10},"DIAGNOSTIC_TEST","Dexa or Biompedance analysis with clinical and biochemical evaluations","All patients will undergo body composition study with DXA or Bioimpedance analysis which are the gold standard to determine % of fat mass and fat free mass, basal biochemical examinations and oral glucose tolerance test (OGTT), and clinical evaluation with waist circumference measurement. Moreover, all patients will undergo REMS ultrasound, TBS and BSI evaluation at DXA scan and hand grip test. In addition, all patients will undergo to clinical evaluation with specific nutritional, physical activity and sleep quality questionnaire assessments and an additional volume of blood.",[9,14],[23,28],{"name":24,"role":25,"phone":26,"phoneExt":10,"email":27},"Andrea Giustina, professor","CONTACT","0226435062","giustina.andrea@hsr.it",{"name":29,"role":25,"phone":26,"phoneExt":10,"email":30},"Luigi Di Filippo, medical doctor","difilippo.luigi@hsr.it",{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Andrea Giustina","Professor",[36,38,40],{"name":37,"class":6},"Federico II University",{"name":39,"class":6},"University of Catanzaro",{"name":41,"class":6},"Istituto Auxologico Italiano","100557646","neuroendocrine-regulation-of-bone-fat-crosstalk-in-obesity-100557646",false,"NCT06540820","NEUROENDOCRINE REGULATION OF BONE-FAT CROSSTALK IN OBESITY","Inclusion criteria for subjects with pituitary disease:\n\n* Male and female subject \\> 18-year-old (also fertile patients can be included)\n* Patients with prolactinoma or Cushing disease, Acromegaly or hypogonadism\u002Fhypopituitarism\n* BMI ≥30 Kg\u002Fm2\n* Able to sign an informed consent\n\nInclusion criteria for subjects without pituitary disease\n\n* Male and female subject \\> 18-year-old\n* BMI ≥ 30 Kg\u002Fm2\n* Able to sign an informed consent\n\nExclusion Criteria:\n\n* Male and female subject \\\u003C18-year-old\n* pregnant or breastfeeding women\n* Subject unable to sign informed consent\n* BMI \\\u003C 30 Kg\u002Fm2","ALL","18 Years",{"count":51,"type":52},150,"ESTIMATED","OBSERVATIONAL","To study the effect of neuroendocrine dysfunctions on bone health in obesity",[56,57,58],"Obesity; Endocrine","Pituitary Dysfunction","Bone Health","NOT_YET_RECRUITING","2024-08-02",{"date":62,"type":63},"2024-08-06","ACTUAL",{"date":65,"type":52},"2024-09",{"date":67,"type":52},"2025-09",{"name":5,"class":6}]