[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100553919":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":23,"responsibleParty":36,"collaborators":23,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":23,"eligibilityCriteria":44,"healthyVolunteers":45,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":23,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":61,"whyStopped":23,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":23},{"fullName":5,"class":6},"Boston VA Research Institute, Inc.","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"real NFB from DMN","EXPERIMENTAL","Participants will receive NFB from their DMN",[13],"Other: fMRI based neurofeedback",{"label":15,"type":10,"description":16,"interventionNames":17},"sham NFB from motor cortex","Participants will receive NFB from their motor cortex",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"fMRI based neurofeedback","participants will receive neurofeedback from their brain in order to modify their own brain function",[9,15],null,[25],{"name":26,"affiliation":5,"role":27},"margaret niznikiewicz, phd","PRINCIPAL_INVESTIGATOR",[29,33],{"name":26,"role":30,"phone":31,"phoneExt":23,"email":32},"CONTACT","6176534627","margaret_niznikiewicz@hms.harvard.edu",{"name":34,"role":30,"phone":23,"phoneExt":23,"email":35},"Susan Whitfield-Gabrieli, PhD","s.whitfield-gabrieli@northeastern.edu",{"type":37,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR","100553919","neurofeedback-in-clinical-high-risk-100553919",false,"NCT06492343","Neurofeedback in Clinical High Risk","Real Time Neurofeedback, Its Neurotransmitter Underpinnings, and Therapeutic Effects, in Clinical High Risk Individuals","Inclusion Criteria:\n\n* For CHR Inclusion:\n\n  1. 12-30 years old\n  2. Native speaker or early learner (by age of 6) of English\n  3. COPS diagnostic criteria met For HC Inclusion\n\n  \u003C!-- -->\n\n  1. 12-30 years old\n  2. Native speaker or early learner (by age of 6) of English\n  3. Provides a match with CHR subject on demographic matching variables\n\n     Exclusion Criteria:\n\n     For CHR:\n\n     Exclusion:\n\n  \u003C!-- -->\n\n  1. Meeting DSM-5 criteria for lifetime psychotic disorder, including affective psychoses\n  2. WASI-II IQ \\\u003C 70\n  3. Psychosis risk symptoms caused by other psychiatric disorders (including substance use\u002Fmisuse)\n  4. Congenital or acquired CNS disorder that could account for psychosis-risk or cognitive symptoms\n  5. Medication that interferes with assessment \u002F presentation of psychosis risk or that could account for psychosis risk symptoms\n  6. Antipsychotic medication administered in the absence of evidence the individual was still in the CHR state when treatment began\n  7. Inability or refusal to provide informed consent\n\n     For HC:\n\n  \u003C!-- -->\n\n  1. Meets criteria for a psychosis-risk syndrome\n  2. Current or previous diagnosis for psychotic di sorder\n  3. DSM-5 Cluster A personality disorder\n  4. First degree biological relative with psychotic disorder or psychotic symptoms\n  5. Current use of psychotropic medication\n  6. WASI-II IQ \\\u003C70\n  7. Congenital or acquired CNS disorder that interferes with cognition or produces psychosis risk-like symptoms\n  8. Inability or refusal to provide informed consent",true,"ALL","12 Years","30 Years",{"count":50,"type":51},40,"ESTIMATED","INTERVENTIONAL",[54],"NA","The goal of this trial is to test whether fMRI based neurofeedback from default mode network (DMN) will reduce DMN hyperconnectivity in clinical high risk individuals, which will lead to reductions in clinical symptoms and improve cognitive performance.",[57,58],"Real Neurofeedback From DMN","Sham Neurofeedback From Motor Cortex",[60],"fMRI, neurofeedback, DMN, functional connectivity","NOT_YET_RECRUITING","2024-07-01",{"date":64,"type":65},"2024-07-09","ACTUAL",{"date":67,"type":51},"2024-09",{"date":69,"type":51},"2028-12",{"name":5,"class":6}]