[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602379":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":59,"collaborators":61,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":26,"eligibilityCriteria":71,"healthyVolunteers":72,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":26,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":26,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Trustees of Princeton University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Neurofeedback","EXPERIMENTAL","Active neurofeedback will reinforce negative dlPFC-hippocampal functional connectivity, as this is expected to increase memory control ability.",[13],"Behavioral: Active Real-time fMRI Neurofeedback",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Neurofeedback","SHAM_COMPARATOR","Participants in the control neurofeedback group will receive the same instructions as the experimental group, but will receive sham neurofeedback.",[19],"Behavioral: Sham Real-time fMRI neurofeedback",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Active Real-time fMRI Neurofeedback","Active neurofeedback to target a functional connection associated with increased memory control ability",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham Real-time fMRI neurofeedback","Sham neurofeedback",[15],[32],{"name":33,"affiliation":34,"role":35},"Kenneth A. Norman, Ph.D.","Princeton University","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Augustin C. Hennings, Ph.D.","CONTACT","609-258-5032","gus.hennings@princeton.edu",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Princeton Neuroscience Institute","RECRUITING","Princeton","New Jersey","08540","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-74.65905,40.34872,{"lat":55,"lon":54},[58],{"name":38,"role":39,"phone":26,"phoneExt":26,"email":41},{"type":60,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[62],{"name":63,"class":64},"National Institute of Mental Health (NIMH)","NIH","100602379","neurofeedback-to-reduce-spontaneous-recovery-of-threat-expectancy-100602379",false,"NCT07122739","Neurofeedback to Reduce Spontaneous Recovery of Threat Expectancy","Reducing Spontaneous Recovery Using Functional Connectivity Based Real-time Functional Magnetic Resonance Imaging Neurofeedback Targeting the Memory Control Network","Inclusion Criteria:\n\n* Adults aged 18-50\n* No history of psychiatric disorders or neurological disorders affecting the central nervous system.\n* Are not currently taking psychoactive medication or drugs of abuse.\n* Must be eligible to enter an MRI (i.e., no permanent metal or medical implants)\n* Normal color vision\n* Right-handed\n* Full reading and writing English comprehension\n* Must exhibit spontaneous recovery behavior as determined by an experimenter in a prescreening experimental session\n* Must be able to provide informed consent\n\nExclusion Criteria:\n\n* Pregnancy (female participants)\n* Outside of age range\n* History of psychiatric or neurological disease\n* Currently taking psychoactive medication or drugs of abuse\n* Color blindness\n* Primary left-handedness\n* Less than full reading and writing English comprehension\n* Do not exhibit spontaneous recovery behavior as determined by an experimenter in a prescreening experimental session\n* Refusing to provide informed consent",true,"ALL","18 Years","50 Years",{"count":77,"type":78},40,"ESTIMATED","INTERVENTIONAL",[81],"NA","This study tests the efficacy of a new behavioral intervention with the goal of reducing spontaneous recovery of threat expectancy in healthy adults. This real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention delivers feedback based on a functional connection between the prefrontal cortex and the hippocampus.",[84],"Healthy","2026-02-20",{"date":87,"type":88},"2026-02-23","ACTUAL",{"date":90,"type":88},"2025-07-17",{"date":92,"type":78},"2028-06",{"name":5,"class":6},1]