[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100508822":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":27,"centralContacts":31,"locations":41,"responsibleParty":59,"collaborators":61,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":18,"enrollmentInfo":78,"targetDuration":18,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":44,"whyStopped":18,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Duke University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Female adults with chronic pain who take prescribed opioid medications","EXPERIMENTAL","Opioid taking participants will undergo two study visits, one for each opioid phase (\"peak\" or \"trough\")",[13],"Other: Opioid Phase",{"label":15,"type":16,"description":17,"interventionNames":18},"Female adults with chronic pain who do not take opioid medications","NO_INTERVENTION","Participants with chronic pain who are not taking opioids will undergo one study visit",null,{"label":20,"type":16,"description":21,"interventionNames":18},"Healthy controls","Healthy female participants who are not taking opioids will undergo one study visit",[23],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":18},"Opioid Phase","Opioid-taking patients are assigned to take their prescribed opioid medication before (\"peak\" opioid phase) during 1 scan and after (\"trough\" opioid phase) during the other MRI scan",[9],[28],{"name":29,"affiliation":5,"role":30},"Katherine T Martucci, PhD","PRINCIPAL_INVESTIGATOR",[32,37],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":36},"HAPN Lab Manager","CONTACT","919-684-2758","chronicpainresearch@duke.edu",{"name":38,"role":34,"phone":39,"phoneExt":18,"email":40},"Angelina Xiong, BS","919-684-3136","angelina.xiong@duke.edu",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Duke University Medical Center","RECRUITING","Durham","North Carolina","27710","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-78.89862,35.99403,{"lat":54,"lon":53},[57],{"name":33,"role":34,"phone":35,"phoneExt":18,"email":58},"ChronicPainResearch@duke.edu",{"type":60,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[62,65],{"name":63,"class":64},"National Institutes of Health (NIH)","NIH",{"name":66,"class":64},"National Institute on Drug Abuse (NIDA)","100508822","neuroimaging-of-opioid-phase-opal-100508822",false,"NCT05905419","Neuroimaging of Opioid Phase (OPAL)","Neurobiological Consequences of Long-Term Opioid Therapy in the Brain and Spinal Cord","OPAL","Inclusion Criteria for Healthy Controls:\n\n1. female and ages 18+\n2. ability to read\u002Funderstand English and give consent to participate\n3. no current or history of chronic pain\n4. not regularly taking any pain-relieving or mood-altering medications (per PI discretion)\n5. absence of use of opioid medications\n\nInclusion Criteria for Individuals with Chronic Pain:\n\n1. female and ages 18 +\n2. ability to read\u002Funderstand English and give consent to participate\n3. self-reported or physician diagnosis of fibromyalgia and\u002For chronic pain\n4. current use of opioid medication(s) for inclusion in the opioid patient group -OR- absence of use of opioid medications for inclusion in the non-opioid patient group\n\nExclusion Criteria (for both groups):\n\n1. limited ability to participate fully in behavioral tasks, longitudinal follow-up\n2. MRI contraindication\n3. any factors that at the discretion of the investigators would adversely affect the participant or the integrity of the study\n4. male",true,"FEMALE","18 Years",{"count":79,"type":80},140,"ESTIMATED","INTERVENTIONAL",[83],"NA","The purpose of this study is to compare activity in the brains of female adults with chronic pain and\u002For opioid use, and healthy female adults that may help to develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.",[86,87],"Chronic Pain","Opioid Use",[89,90,91,92,93,94,95,96,97],"fibromyalgia","women","brain","functional MRI","opioid","opiate","narcotic","chronic pain","pain","2026-06-01",{"date":100,"type":101},"2026-06-03","ACTUAL",{"date":103,"type":101},"2023-06-01",{"date":105,"type":80},"2027-06-30",{"name":5,"class":6},1]