[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631188":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":18,"centralContacts":29,"locations":35,"responsibleParty":52,"collaborators":18,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":18,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":38,"whyStopped":18,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"McGill University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Active intervention","EXPERIMENTAL","Physical Exercise Training",[13],"Behavioral: Physical Exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"Waitlist","NO_INTERVENTION","Participants assigned to the waitlist group will not receive the physical exercise program during the 12-week intervention period but will continue their usual care. After completion of the study assessments, they will be offered access to the exercise program.",null,{"label":20,"type":6,"description":21,"interventionNames":22},"Healthy controls","Sex- and age-matched healthy volunteers will only participate in the first 2 weeks of PE intervention",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":18},"BEHAVIORAL","Physical Exercise","Patients in the PE training group will perform a 12-week online program comprising three 60-minute weekly training sessions. The training program is delivered by certified kinesiologists through a secured online platform.\n\nHealthy controls will participate only in the first 2 weeks of PE training.",[9,20],[30],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},"Carlos Gevers Montoro, PhD","CONTACT","+1-8199790448","carlos.geversmontoro@mcgill.ca",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Montreal General Hospital","RECRUITING","Montreal","Quebec","H3H 1V6","Canada","CA",{"type":45,"coordinates":46},"Point",[47,48],-73.58781,45.50884,{"lat":48,"lon":47},[51],{"name":31,"role":32,"phone":33,"phoneExt":18,"email":34},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Mathieu Roy","Associate Professor","100631188","neuroimmune-responses-to-exercise-in-chronic-back-pain-100631188",false,"NCT07497425","Neuroimmune Responses to Exercise in Chronic Back Pain","Neuroimmune Responses to Physical Exercise Training in Chronic Primary Low Back Pain","eCLBP","Inclusion Criteria-CLBP patients:\n\n* Have a diagnosis of chronic primary LBP, according to the criteria established by NIH Task Force on Research Standards for CLBP (Deyo et al., 2015). This will be determined by 1) the response to the National Institutes of Health minimum dataset for CLBP (NIH-md), including that LBP has been persistent for at least 3 months or recurrent for at least half of the days in the past 6 months, and 2) the results of a complete case history and physical examination (including functional tasks, quantitative sensory testing, and, if needed, neuro-orthopedic, palpation and range of motion assessments);\n* Report a CLBP intensity of at least 4 in a 0-10 numerical rating scale (0 = no pain, 10 = maximum possible pain).\n\nInclusion Criteria-Healthy controls:\n\n\\- Be over 18 years and under 75 years of age;\n\nExclusion Criteria-CLBP patients:\n\n* Present any red flags indicative of serious pathology comorbid or as the cause of CLBP (Finucane et al., 2020);\n* Have a CLBP phenotype characterized by predominant nociceptive (as in fracture, infection, malignancy, inflammatory or rheumatic spondyloarthropathy, cauda equina syndrome, confirmed by MRI when suspected) or neuropathic pain mechanisms, the latter assessed through score in the DN4 questionnaire (Nijs, et al., 2024);\n* Present chronic or acute pain of higher intensity or perceived disability in any other body site than the low back;\n* Medical history of diabetes, neurological or psychiatric disorder;\n* Presence of significant cardiorespiratory problems or any other potential contraindications to physical exercise as assessed through the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+);\n* Following a regular structured PE training program (\\>60 min\u002Fweek) at study's onset, and;\n* Presence of any contraindications to MRI examination (including any metallic implants or devices, being pregnant, and claustrophobia).\n\nExclusion criteria-Healthy controls:\n\n* Have symptoms or a diagnosis of any acute or chronic pain conditions;\n* Medical history of diabetes, neurological or psychiatric disorder;\n* Presence of significant cardiorespiratory problems or any other potential contraindications to physical exercise as assessed through the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+);\n* Following a regular structured PE training program (\\>60 min\u002Fweek) at study's onset, and;\n* Presence of any contraindications to MRI examination (including any metallic implants or devices, being pregnant, and claustrophobia).",true,"ALL","18 Years","75 Years",{"count":69,"type":70},216,"ESTIMATED","INTERVENTIONAL",[73],"NA","The goal of this mechanistic clinical trial is to learn how physical exercise affects the body and brain in people with chronic low back pain. The study will examine whether a 12-week online exercise program changes these measures compared with a waitlist group. Researchers will also study immune activity and brain function in people with chronic low back pain and compare them with healthy participants. Participants will complete questionnaires, provide blood samples, and undergo brain imaging scans.",[76],"Chronic Low Back Pain (CLBP)",[78,79,80,81,82,83],"mechanisms","immune system","inflammation","brain","chronic pain","exercise","2026-03-24",{"date":86,"type":87},"2026-03-27","ACTUAL",{"date":89,"type":87},"2025-06-01",{"date":91,"type":70},"2029-06-30",{"name":5,"class":6},1]