[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622787":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":10,"responsibleParty":25,"collaborators":27,"id":31,"slug":32,"hasResults":33,"nctId":34,"briefTitle":35,"officialTitle":36,"acronym":10,"eligibilityCriteria":37,"healthyVolunteers":38,"sex":39,"minAge":40,"maxAge":41,"enrollmentInfo":42,"targetDuration":10,"studyType":45,"phases":10,"briefSummary":46,"conditions":47,"keywords":51,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":10},{"fullName":5,"class":6},"University of Health Sciences Balikesir Hospital Eduation and Research","OTHER_GOV",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"No Previous General Anesthesia",null,"Healthy volunteers aged 18-65 years who have never undergone general anesthesia. This control group will undergo elective cholecystectomy surgery under general anesthesia. Blood samples will be collected preoperatively and 24 hours postoperatively to measure serum BDNF, IL-1β, and HMGB1 levels. Cognitive function will also be assessed at both time points.",{"label":13,"type":10,"description":14,"interventionNames":10},"Previous General Anesthesia Exposure","Patients aged 18-65 years scheduled for elective cholecystectomy who have received general anesthesia at least once or multiple times in the past. Blood samples will be collected preoperatively and 24 hours postoperatively to measure serum BDNF, IL-1β, and HMGB1 levels. Cognitive function will also be assessed at both time points. This group will be compared with the control group to evaluate the impact of repeated anesthesia exposure on neuroinflammatory biomarkers and neurotrophic balance.",[16],{"name":17,"affiliation":18,"role":19},"sevgi kutlusoy, Assoc. Prof. Dr.","Saglik Bilimleri Universitesi","STUDY_CHAIR",[21],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","+905449696144","stopal70@hotmail.com",{"type":26,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[28],{"name":29,"class":30},"Malatya Turgut Ozal University","OTHER","100622787","neuroinflammatory-biomarkers-after-general-anesthesia-a-comparison-study-100622787",false,"NCT07388160","Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study","Evaluation of Preoperative and Postoperative Serum BDNF, IL-1β, and HMGB1 Levels and Cognitive Changes in Patients Undergoing General Anesthesia: Differences Between Patients With No Prior General Anesthesia and Those With Multiple Anesthesia Exposures","Inclusion Criteria:\n\n* Age 18-65 years\n* Scheduled for elective cholecystectomy surgery\n* Either no previous general anesthesia exposure OR at least one or more previous general anesthesia exposures\n* Ability to provide informed consent\n* American Society of Anesthesiologists (ASA) physical status I-II\n\nExclusion Criteria:\n\n* Chronic neurological diseases (Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc.)\n* Psychiatric illness requiring medication\n* Metabolic syndrome (diabetes mellitus, hypertension, cardiac disease)\n* Chronic inflammatory diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.)\n* Corticosteroid or immunosuppressive therapy within the last 6 months\n* Patients requiring intensive care admission\n* Pregnancy or breastfeeding\n* Known allergy to anesthetic agents\n* Inability to provide informed consent",true,"ALL","18 Years","65 Years",{"count":43,"type":44},160,"ESTIMATED","OBSERVATIONAL","This prospective, observational study investigates the impact of repeated general anesthesia exposure on neuroinflammatory biomarkers and neurotrophic factors. The study will enroll 160 adult patients (aged 18-65 years) scheduled for elective cholecystectomy surgery, divided into two groups: patients with no previous general anesthesia exposure (n=80) and patients with at least one or more previous general anesthesia exposures (n=80).\n\nSerum levels of Brain-Derived Neurotrophic Factor (BDNF), Interleukin-1 beta (IL-1β), and High Mobility Group Box 1 (HMGB1) will be measured using ELISA method at two time points: preoperatively (baseline) and 24 hours postoperatively. Cognitive function will also be assessed at both time points.\n\nThe primary objective is to evaluate whether multiple exposures to general anesthesia lead to significant differences in serum BDNF, IL-1β, and HMGB1 levels, reflecting changes in neurotrophic balance and neuroinflammatory response. This study aims to provide insights into the potential biochemical mechanisms underlying anesthesia-related cognitive changes and contribute original clinical data to the current literature on general anesthesia safety and neurobiological effects.",[48,49,50],"Anesthesia","Neuroinflammation","Cognitive Disorders",[52,53,54,49,55,56,57,58,59],"Brain Derived Neurotrophic Factor","Interleukin-1 beta","General Anesthesia","Cognitive Dysfunction","Biomarkers","Sevofluran","Inflammatory Cytokines","Anesthesia Neurotoxicity","NOT_YET_RECRUITING","2026-01-30",{"date":63,"type":64},"2026-02-04","ACTUAL",{"date":66,"type":44},"2026-01-25",{"date":68,"type":44},"2026-09-25",{"name":5,"class":6}]