[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591303":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":40,"locations":50,"responsibleParty":70,"collaborators":44,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":75,"sex":81,"minAge":82,"maxAge":44,"enrollmentInfo":83,"targetDuration":44,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":99,"overallStatus":111,"whyStopped":44,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Instituto do Cancer do Estado de São Paulo","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"CELIAC PLEXUS NEUROLYSIS","ACTIVE_COMPARATOR","The patient, under sedation and breathing spontaneously with oxygen support, will be placed in the horizontal prone position. Fluoroscopy will be used to locate the first lumbar vertebra, which will serve as a reference for the puncture site. Two 22G × 15 cm needles will be introduced bilaterally, up to 6 cm from the midline at the level of L1, and directed superiorly toward the transverse process of L1 under coaxial vision. Once they reach the vertebral body bilaterally, the needles will be positioned anterior to the vertebral body of L1, in the retroperitoneal region. The needle stylet will be removed, and the absence of blood, cerebrospinal fluid, or urine returning through the needle will be verified. If none of these signs are present, 2 ml of non-ionic contrast will be administered through the needle to confirm proper positioning in the retroperitoneum. After confirmation, 5 ml of absolute alcohol will be injected bilaterally.",[13],"Procedure: Celiac Plexus Neurolysis - 5 ml of absolute alcohol (100%)",{"label":15,"type":16,"description":17,"interventionNames":18},"SPLANCHNIC NERVE NEUROLYSIS","EXPERIMENTAL","The patient, under spontaneous breathing with oxygen support, will be placed in the horizontal prone position and supported by cushions placed under the iliac crests and chest. With a mark maintained over T11, the fluoroscopy machine will be positioned obliquely (approximately 45º), and the movement of the diaphragm-as well as its relationship with the vertebral body-will be observed during inspiration and expiration. The entry point will be at the junction of the rib and the vertebral body. The needle will be introduced using coaxial visualization to reach the lateral aspect of the vertebral body, near the costovertebral angle. With the fluoroscopy in profile, the needle will be advanced to the anterior third of the vertebral body, and any return of blood or cerebrospinal fluid will be checked. Non-ionic contrast will then be injected to confirm the needle position in both anteroposterior and lateral views. Finally, 5 ml of absolute alcohol will be injected through each needle.",[19],"Procedure: Splanchnic nerve neurolysis - 5 ml of absolute alcohol (100%)",[21,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Splanchnic nerve neurolysis - 5 ml of absolute alcohol (100%)","Splanchnic neurolysis will be performed with 5 ml of absolute alcohol on each side at the level of the eleventh thoracic vertebra.",[15],[27,28,29],"SPLANCHNIC NERVE BLOCK","SPLANCHNIC NERVE BLOCKADE","SPLANCHNIC BLOCK",{"type":22,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"Celiac Plexus Neurolysis - 5 ml of absolute alcohol (100%)","Celiac plexus neurolysis will be performed with 5 ml of absolute alcohol on each side at the level of the first lumbar vertebra.",[9],[35],"Celiac plexus block",[37],{"name":38,"affiliation":5,"role":39},"Angela M Sousa, MD. PhD.","STUDY_DIRECTOR",[41,46],{"name":38,"role":42,"phone":43,"phoneExt":44,"email":45},"CONTACT","+55 1198558-8339",null,"angela.sousa@hc.fm.usp.br",{"name":47,"role":42,"phone":48,"phoneExt":44,"email":49},"Karenthan A Rodrigues, MD.","+55 1199811-0737","karenthan.abreu@hc.fm.usp.br",[51],{"facility":52,"status":44,"city":53,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Instituto de Cancer Do Estado","São Paulo","01246-000","Brazil","BR",{"type":58,"coordinates":59},"Point",[60,61],-46.63611,-23.5475,{"lat":61,"lon":60},[64,66,68],{"name":47,"role":42,"phone":65,"phoneExt":44,"email":49},"+55 11 998110737",{"name":38,"role":42,"phone":67,"phoneExt":44,"email":45},"+55 11 38933268",{"name":47,"role":69,"phone":44,"phoneExt":44,"email":44},"PRINCIPAL_INVESTIGATOR",{"type":69,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"amsousa","Coordinator of the Pain Group at the Instituto do Cancer do Estado de São Paulo.","100591303","neurolytic-block-techniques-in-abdominal-visceral-cancer-pain-100591303",false,"NCT06978673","Neurolytic Block Techniques In Abdominal Visceral Cancer Pain","Comparison of Neurolytic Block Techniques for the Treatment of Abdominal Visceral Pain and Their Influence On The Quality of Life of Patients With Cancer","CONCERN","Inclusion Criteria:\n\nPatients aged 18 years or older Presence of localized visceral pain in the upper abdomen originating from cancer of the stomach, duodenum, distal esophagus, ascending or transverse colon, liver, biliary tract, or pancreas\n\nIneffectiveness of analgesic treatment with third-step opioids according to the WHO analgesic ladder, including:\n\nOpioids (≥ 60 mg\u002Fday of morphine equivalents) Antidepressants (tricyclic or dual-action), at any dosage Gabapentinoids, at any dosage Presence of side effects from analgesics that are difficult to manage with medication\n\nExclusion Criteria:\n\nPresence of ascites Presence of deep vein thrombosis Presence of hepatic failure: Child-Pugh class B or C Presence of renal failure: estimated glomerular filtration rate (eGFR) \\\u003C 60 ml\u002Fmin\u002F1.73 m² Use of any anticoagulant medication\n\nClinical coagulation disorder, defined as:\n\nINR \\> 1.5 Prothrombin activity \\\u003C 70% or prothrombin time \\> 13.5 seconds aPTT \\> 40 seconds Cardiovascular failure: NYHA class III","ALL","18 Years",{"count":84,"type":85},64,"ESTIMATED","INTERVENTIONAL",[88],"NA","The neurolytic blocks of sympathetic chains are commonly used for the treatment of cancer-related pain. This study aims to compare celiac plexus neurolysis and splanchnic nerve neurolysis for the treatment of abdominal visceral pain and its influence on the quality of life of patients with cancer.",[91,92,93,94,95,96,97,98],"Cancer, Malignant Tumors","Abdominal Cancer","Cancer Pain","Visceral Pain","Cancer-related Pain","Pain Management","Celiac Ganglia","Sympathetic Ganglia",[100,101,102,103,104,105,106,107,108,109,110],"cancer pain","visceral pain","abdominal cancer","cancer","abdominal pain","cancer-related pain","pain management","neurolytic block","splanchnic nerve block","celiac plexus block","sympathetic neurolysis","NOT_YET_RECRUITING","2025-05-30",{"date":114,"type":115},"2025-06-03","ACTUAL",{"date":112,"type":85},{"date":118,"type":85},"2026-12",{"name":5,"class":6},1]