[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100578769":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":45,"centralContacts":49,"locations":55,"responsibleParty":76,"collaborators":53,"id":79,"slug":80,"hasResults":81,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":53,"eligibilityCriteria":84,"healthyVolunteers":85,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":53,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":58,"whyStopped":53,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"State University of New York at Buffalo","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"rTMS","ACTIVE_COMPARATOR","rTMS will be administered and functional and physiological outcomes will be measured before and after each intervention.",[13],"Other: rTMS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham rTMS","SHAM_COMPARATOR","Sham rTMS will be administered and functional and physiological outcomes will be measured before and after each intervention.",[19],"Other: Sham rTMS",{"label":21,"type":10,"description":22,"interventionNames":23},"rTMS with motor training","Subjects will receive the rTMS with motor training for long-term up to 50 sessions. Motor training involves hand motor training.",[13,24],"Behavioral: Motor training",[26,31,37],{"type":6,"name":9,"description":27,"armGroupLabels":28,"otherNames":29},"Intermittent theta burst stimulation (iTBS) will be utilized since they have been reported to have a cortical neuromodulatory effect. The iTBS protocol will be applied over primary motor cortex to investigate its effect on corticospinal excitability and functional outcome. Theta burst stimulation (TBS) consists of bursts of pulses containing 3 pulses at 50 Hz (3 pulses per second) repeated at 200 ms intervals (5 Hz). During iTBS, a 2 second train of TBS is repeated every 10 seconds (600 pulses in 190 seconds).",[9,21],[30],"iTBS",{"type":6,"name":15,"description":32,"armGroupLabels":33,"otherNames":34},"Sham iTBS protocols will be applied with the same parameters as in iTBS protocol. However, sham coil will be used.",[15],[35,36],"Sham iTBS","Sham stimulation",{"type":38,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"BEHAVIORAL","Motor training","The motor training will be focused on participant's hand motor function such as grasping function.",[21],[43,44],"Exercise training","Hand training",[46],{"name":47,"affiliation":5,"role":48},"Hang Jin Jo, PhD","PRINCIPAL_INVESTIGATOR",[50],{"name":47,"role":51,"phone":52,"phoneExt":53,"email":54},"CONTACT","716-829-2905",null,"hangjinj@buffalo.edu",[56],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"The Kimball Tower at The State University of New York at Buffalo","RECRUITING","Buffalo","New York","14214","United States","US",{"type":65,"coordinates":66},"Point",[67,68],-78.87837,42.88645,{"lat":68,"lon":67},[71,75],{"name":72,"role":51,"phone":73,"phoneExt":53,"email":74},"Karen Barnes","(716) 829-6718","barneska@buffalo.edu",{"name":47,"role":48,"phone":53,"phoneExt":53,"email":53},{"type":48,"investigatorFullName":77,"investigatorTitle":78,"investigatorAffiliation":5,"oldNameTitle":53,"oldOrganization":53},"Hang Jin Jo","Assistant Professor","100578769","neuromodulation-after-spinal-cord-injury-to-improve-limb-function-100578769",false,"NCT06815601","Neuromodulation After Spinal Cord Injury to Improve Limb Function","Inclusion Criteria:\n\n* Healthy adults between the ages of 18-75 years old who are right-handed\n* Adults between the ages of 18-75 years old who have had a spinal cord injury (SCI)\n\nExclusion Criteria:\n\nFor both healthy individuals and those with SCI:\n\n* Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease\n* Any debilitating disease prior to the SCI that caused exercise intolerance\n* Ongoing major depression or altered cognitive status\n* Metal plate in skull\n* History of seizures\n* Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs\n* Pregnant females",true,"ALL","18 Years","75 Years",{"count":90,"type":91},60,"ESTIMATED","INTERVENTIONAL",[94],"NA","The University at Buffalo (UB) Department of Rehabilitation Sciences is looking for adult volunteers with and without spinal cord injuries for a study on hand movement. The goal of the study is to learn about how the brain, nerves, and muscles of the body are connected and perform everyday tasks. This may help us to develop ways to improve the hand functions of people with spinal cord injuries.",[97,98],"Spinal Cord Injury","Spinal Cord Injury Cervical",[100,101,102,103,9,104],"spinal cord injury","SCI","Stimulation","Paralysis","transcranial magnetic stimulation","2025-04-14",{"date":107,"type":108},"2025-04-15","ACTUAL",{"date":110,"type":108},"2025-04-10",{"date":112,"type":91},"2028-01",{"name":5,"class":6},1]