[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100583240":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":22,"centralContacts":23,"locations":22,"responsibleParty":29,"collaborators":22,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":22,"eligibilityCriteria":39,"healthyVolunteers":40,"sex":41,"minAge":42,"maxAge":22,"enrollmentInfo":43,"targetDuration":22,"studyType":46,"phases":47,"briefSummary":49,"conditions":50,"keywords":54,"overallStatus":58,"whyStopped":22,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":22},{"fullName":5,"class":6},"Sunnybrook Health Sciences Centre","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment","EXPERIMENTAL","All participants will receive transcranial alternating current stimulation.",[13],"Device: Transcranial Alternating Current Stimulation",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Transcranial Alternating Current Stimulation","Application of low amplitude alternating electric current across the participant's scalp.",[9],[21],"Soterix Medical MxN-33 high definition transcranial electrical stimulator",null,[24],{"name":25,"role":26,"phone":27,"phoneExt":22,"email":28},"Bojana Stefanovic, PhD","CONTACT","1-416-480-5726","bojana@sri.utoronto.ca",{"type":30,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Bojana Stefanovic","Director and Senior Scientist, Physical Sciences, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute","100583240","neuromodulation-and-fmri-in-neurodegenerative-diseases-study-100583240",false,"NCT06873750","Neuromodulation and fMRI in Neurodegenerative Diseases Study","A Pilot Study in Defining the Potential of Transcranial Alternating Current Neuromodulation for Stabilizing Memory and Improving Functional Connectivity in Neurodegeneration","Inclusion Criteria:\n\n1. Be at least 25 years of age;\n2. Have no contraindications to MRI\n3. Have received 8 or more years of formal education\n4. Be fluent in English\n5. Cohort a. must be followed at Sunnybrook Health Sciences Center\n\nCohort a:\n\n* Have been diagnosed with a suspected neurodegenerative disorder or traumatic brain injury (TBI) with memory deficits impacting functional status\n* In case of TBI, cognitive impairment has persisted at least three months post-injury\n* Received score of 16 or lower on the Mini Mental State Examination (MMSE)\n\nCohort b:\n\n* Have no prior diagnosis of a neurodegenerative disorder or post-traumatic brain injury cognitive deficits\n* Be experiencing healthy aging and be age and sex matched to Cohort a.\n\nExclusion Criteria:\n\n1. Have any contraindications to MRI\n2. Be pregnancy\n3. Have any major comorbid medical conditions (as determined by investigators - e.g., comorbid neurological diseases, uncontrolled hypertension or diabetes, malignancy) or major comorbid psychiatric conditions (as determined by investigators - e.g., schizophrenia or bipolar disorder)",true,"ALL","25 Years",{"count":44,"type":45},30,"ESTIMATED","INTERVENTIONAL",[48],"NA","In addition to neuronal loss, dysfunction in brain network connectivity has been identified as a correlate of cognitive deficits in neurodegenerative and post-traumatic brain injury states. Transcranial alternating current stimulation (tACS) has been suggested as a promising, non-invasive, method of normalizing network connectivity and hence improving cognition, notably memory. This study will examine the efficacy of tACS at improving working memory performance in patients with neurodegeneration and its correlation to changes in network connectivity, based on functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) imaging data.",[51,52,53],"Mild Cognitive Impairment","Traumatic Brain Injury","Neurodegeneration",[17,55,56,57],"Neuromodulation","Functional Magnetic Resonance Imaging","Cognitive Assessment","NOT_YET_RECRUITING","2026-04-27",{"date":61,"type":62},"2026-05-01","ACTUAL",{"date":64,"type":45},"2026-06-01",{"date":66,"type":45},"2028-12-01",{"name":5,"class":6}]