[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100474635":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":31,"centralContacts":37,"locations":47,"responsibleParty":69,"collaborators":71,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":41,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":50,"whyStopped":41,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Duke University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"TMS-Randomized","EXPERIMENTAL","Three different closed-loop conditions will be tested, each triggered by the presence of a sustained period of alpha-band power. In the first condition, arrhythmic TMS trains with a stochastic (randomized) inter-pulse interval, will be used to disrupt cortical alpha oscillations and thus be expected to enhance memory performance.",[13],"Device: Transcranial Magnetic Stimulation",{"label":15,"type":10,"description":16,"interventionNames":17},"TMS-Ordered","Three different closed-loop conditions will be tested, each triggered by the presence of a sustained period of alpha-band power. In the second condition, rhythmic (ordered) alpha-frequency TMS trains, with the expectation that this alpha stimulation will further entrain a synchronization during the task and thereby worsen memory performance.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"TMS-Sham","SHAM_COMPARATOR","Three different closed-loop conditions will be tested, each triggered by the presence of a sustained period of alpha-band power. In a third condition, sham stimulation will be delivered at the same randomized inter-pulse interval, but with no TMS delivered to the brain.",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DEVICE","Transcranial Magnetic Stimulation","Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve a variety of cognitive conditions, and to probe the dynamics of normal brain function.",[15,9,19],[30],"TMS rTMS",[32,35],{"name":33,"affiliation":5,"role":34},"Simon W Davis, PhD","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":34},"Andy Liu, MD",[38,43],{"name":33,"role":39,"phone":40,"phoneExt":41,"email":42},"CONTACT","9196841243",null,"simon.davis@duke.edu",{"name":44,"role":39,"phone":45,"phoneExt":41,"email":46},"Emily Finch, BA","9196682842","emily.finch@duke.edu",[48],{"facility":49,"status":50,"city":51,"state":52,"zip":53,"country":54,"countryCode":55,"cosmosGeoPoint":56,"geoPoint":61,"contacts":62},"Duke University Hospital","RECRUITING","Durham","North Carolina","27710","United States","US",{"type":57,"coordinates":58},"Point",[59,60],-78.89862,35.99403,{"lat":60,"lon":59},[63,66],{"name":64,"role":39,"phone":65,"phoneExt":41,"email":42},"Simon Davis, PhD","919-668-0437",{"name":67,"role":39,"phone":68,"phoneExt":41,"email":46},"Emily Finch, BS","9196682299",{"type":70,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR",[72],{"name":73,"class":74},"National Institute on Aging (NIA)","NIH","100474635","neuromodulation-of-memory-in-aging-100474635",false,"NCT05460468","Neuromodulation of Memory in Aging","Adaptive Neuromodulation of Working Memory Networks in Aging and Dementia","TMS-AD","Inclusion Criteria:\n\n* English Speaking\n* Willing to provide consent\n\nExclusion Criteria:\n\n* History of any Axis I DSM-V disorder, excluding major depressive disorder or generalized anxiety disorders\n* Current history of substance abuse or dependence (excluding nicotine)\n* Intracranial implants (e.g. aneurysms clips, shunts, stimulators, cochlear implants, or electrodes), cardiac pacemakers, or vagus Nerve stimulation device\n* Increased risk of seizure for any reason, including prior diagnosis of epilepsy, seizure disorder, increased intracranial pressure, or history of significant head trauma with loss of consciousness for ≥ 5 minutes.\n* Neurological disorder including, but not limited to: space occupying brain lesion; any history of seizures, history of cerebrovascular accident; fainting, cerebral aneurysm, Dementia, Hungtington chorea; Multiple Sclerosis.\n* Current use of medications known to lower the seizure threshold and\u002For affect working memory",true,"ALL","18 Years","75 Years",{"count":88,"type":89},150,"ESTIMATED","INTERVENTIONAL",[92],"NA","The proposed research will use closed-loop transcranial magnetic stimulation (TMS) based on individualized brain networks to establish parameters that can reliably control brain states. This will be tested in healthy aging and mild cognitive impairment (MCI) cohorts. The investigators will study network activation and neural oscillatory mechanisms underlying the network that regulates working memory and then target this network using closed-loop TMS to the Prefrontal Cortex. Investigators will measure the impact of TMS on working memory performance and task-based neural activity. The project will use brain stimulation and network modeling techniques to enhance working memory in healthy older adults and MCI and will demonstrate the value of closed-loop, network-guided TMS for future clinical applications.",[95,96],"Mild Cognitive Impairment","MCI",[98,26,99],"TMS","Memory","2025-10-09",{"date":102,"type":103},"2025-10-14","ACTUAL",{"date":105,"type":103},"2024-03-28",{"date":107,"type":89},"2027-06-30",{"name":5,"class":6},1]