[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561152":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":45,"centralContacts":49,"locations":57,"responsibleParty":79,"collaborators":28,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":28,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":28,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":60,"whyStopped":28,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Father Flanagan's Boys' Home","OTHER",[8,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Neurotypical Youth\u002FAdults","EXPERIMENTAL","Compared with the sham controls, those receiving the transcutaneous current stimulation will demonstrate alterations in the strength of the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence. Moreover, the extent of the alterations in the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence will be tightly linked with the clinical presentations of persons with CP.",[13,14,15,16,17],"Behavioral: Clinical Assessments","Behavioral: Brain-Spinal Cord fMRI","Behavioral: Hoffmann Reflex Assessments","Behavioral: MEG Imaging","Behavioral: Transcutaneous Current Stimulation",{"label":19,"type":10,"description":20,"interventionNames":21},"Cerebral Palsy Youth\u002FAdults","Compared with the sham controls, those receiving the transcutaneous current stimulation will demonstrate alterations in the strength of the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence. Moreover, the extent of the alterations in the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence will be tightly linked with the clinical presentations of controls.",[13,14,15,16,17],[23,29,33,37,41],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"BEHAVIORAL","Clinical Assessments","The participant will undergo a battery of clinical assessments to identify the upper extremity motor performance, sensory acuity, and ability to complete activities of daily living. Tests 1-5 will be completed separately for each hand. All participants will be video recorded while completing these assessments. The recordings will be used for grading tasks and data analysis: Box and Blocks, 9-hold peg board, Test of Arm Selective Control, Sensory Acuity Testing, KINARM End-Point Lab Sensory Test, Section GG of the inpatient Rehabilitaion Facility-Patient Assessment Instrument, NEURO-QOL Upper Extremity Function Scale, Edinburgh Handed Inventory",[19,9],null,{"type":24,"name":30,"description":31,"armGroupLabels":32,"otherNames":28},"Brain-Spinal Cord fMRI","Resting state, brain-spinal cord activity, spinal cord microstructure, magnetic resonance spectroscopy",[19,9],{"type":24,"name":34,"description":35,"armGroupLabels":36,"otherNames":28},"Hoffmann Reflex Assessments","Hmax 20-50 stimulations of increasing intensity. Next, the participant will sit quietly as 10 stimulations will be delivered at the participant's Hmax with an interstimulus interval of 15 seconds. Subsequently, stimulations at the participant's Hmax will be applied as the participants produce a contraction of 10-20% of their maximum voluntary contraction (MVC). The target contraction level will be shown in real-time based on the FCR EMG activity. The participant maintains their EMG activity at the target level for 6.5 seconds as 10 stimulations are delivered at the participants Hmax.",[19,9],{"type":24,"name":38,"description":39,"armGroupLabels":40,"otherNames":28},"MEG Imaging","Resting state, somatosensory, isometric force matching, entrainment",[19,9],{"type":24,"name":42,"description":43,"armGroupLabels":44,"otherNames":28},"Transcutaneous Current Stimulation","Cortical stimulation, spinal cord stimulation - sham and stim",[19,9],[46],{"name":47,"affiliation":5,"role":48},"Max J Kurz, PhD","PRINCIPAL_INVESTIGATOR",[50,54],{"name":47,"role":51,"phone":52,"phoneExt":28,"email":53},"CONTACT","531-355-8916","max.kurz@boystown.org",{"name":55,"role":51,"phone":56,"phoneExt":28,"email":28},"Jennifer M Kime, MS","531-355-8959",[58],{"facility":59,"status":60,"city":61,"state":62,"zip":63,"country":64,"countryCode":65,"cosmosGeoPoint":66,"geoPoint":71,"contacts":72},"Boys Town National Research Hospital","RECRUITING","Boys Town","Nebraska","68010","United States","US",{"type":67,"coordinates":68},"Point",[69,70],-96.13196,41.26111,{"lat":70,"lon":69},[73,76,78],{"name":74,"role":51,"phone":75,"phoneExt":28,"email":53},"Max J Kime, PhD","402-559-3415",{"name":55,"role":51,"phone":56,"phoneExt":28,"email":77},"jennifer.kime@boystown.org",{"name":47,"role":48,"phone":28,"phoneExt":28,"email":28},{"type":48,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Max Kurz","Director of PoWER Lab","100561152","neuromodulation-of-the-cortex-and-spinal-cord-100561152",false,"NCT06586437","Neuromodulation of the Cortex and Spinal Cord","Inclusion Criteria:\n\n* For Cerebral Palsy Participants:\n* Gross Motor Function Classification score (GMFCS) levels between I-IV\n* For Neurotypical Controls:\n* No known atypical neurodevelopment (e.g. autism, Down Syndrome, ADHD, etc.)\n\nExclusion Criteria:\n\n* For Cerebral Palsy Participants:\n* Pregnancy\n* Any condition that, in the opinion of the investigator, is a contraindication to participation\n* The presence of any ferrous metal implant, including orthodonture, which may interfere with the MEG data acquisition and\u002For be an MRI safety concern\n* No orthopedic surgery in the last 6 months or metal in their body that would preclude the use of an MRI\n* For Neurotypical Controls:\n\nPregnancy\n\n* Any condition that, in the opinion of the investigator, is a contraindication to participation\n* The presence of any ferrous metal implant, including orthodonture, which may interfere with the MEG data acquisition and\u002For be an MRI safety concern\n* No orthopedic surgery in the last 6 months or metal in their body that would preclude the use of an MRI",true,"ALL","11 Years","45 Years",{"count":93,"type":94},50,"ESTIMATED","INTERVENTIONAL",[97],"NA","Specific Aim 1: To further quantify the difference in the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence of persons with CP.\n\nOverall hypotheses: The sensorimotor cortical activity, spinal cord activity, and corticospinal coherence will be uncharacteristic in persons with CP when compared with neurotypical controls. Furthermore, the extent of the alterations in the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence will be tightly linked with the clinical presentations of persons with CP.\n\nSpecific Aim 2: To investigate the effect of transcutaneous current stimulation applied over the cortex and\u002For spinal cord on the sensorimotor cortical activity, spinal cord dynamics, and corticospinal coherence.\n\nOverall hypotheses: Compared with the sham controls, those receiving the transcutaneous current stimulation will demonstrate alterations in the strength of the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence. Moreover, the extent of the alterations in the sensorimotor cortical activity, spinal cord activity, and corticospinal coherence will be tightly linked with the clinical presentations of persons with CP.",[100],"Cerebral Palsy",[100,102,103,104,105],"Neuromodification","Brain","Spinal Cord","Upper Extremity","2025-09-24",{"date":108,"type":109},"2025-09-29","ACTUAL",{"date":111,"type":109},"2024-01-17",{"date":113,"type":94},"2029-08",{"name":5,"class":6},1]