[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634823":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":11,"centralContacts":11,"locations":11,"responsibleParty":30,"collaborators":11,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":11,"eligibilityCriteria":40,"healthyVolunteers":41,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":11,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":57,"whyStopped":11,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":11},{"fullName":5,"class":6},"Kaohsiung Veterans General Hospital.","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"controls group","SHAM_COMPARATOR",null,[13],"Behavioral: the strengthening program",{"label":15,"type":16,"description":17,"interventionNames":18},"Group A with the corrective knee orthosis","EXPERIMENTAL","patients with moderate knee osteoarthritis (Kellgren-Lawrence grade II-III) who will receive a valgus-corrective knee orthosis.",[13],{"label":20,"type":21,"description":22,"interventionNames":23},"Group B without the corrective knee orthosis","PLACEBO_COMPARATOR","patients with moderate knee osteoarthritis (Kellgren-Lawrence grade II-III) who will not receive a valgus-corrective knee orthosis.",[13],[25],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":11},"BEHAVIORAL","the strengthening program","The isometric knee-extension strengthening program from session 1 to session 9 as follows:\n\n1. Before the first training session each week, one-repetition maximum (1RM) will be measured to determine the training intensity for that week.\n2. Training frequency: Three sessions per week on non-consecutive days, for a total of 3 weeks (9 sessions).\n3. Training intensity: 60% of 1RM. The goal is to improve quadriceps strength and endurance while reducing joint loading.\n4. Each session will consist of four sets: 30 repetitions in the first set and 15 repetitions in sets 2-4.\n5. Rest intervals of 30 seconds will be provided between sets, during which the blood-flow-restriction device will remain in place.",[15,20,9],{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","CHEN YUEH","Doctor of Medicine","100634823","neuromuscular-control-and-motor-unit-behavior-in-patients-with-knee-osteoarthritis-100634823",false,"NCT07544693","Neuromuscular Control and Motor Unit Behavior in Patients With Knee Osteoarthritis","Neuromuscular Control and Motor Unit Behavior in Patients With Knee Osteoarthritis: a Randomized Single-blind Trial of Muscle Training and Knee Orthosis Intervention","Inclusion Criteria:\n\n\\- 1. age 55 to 75 years.\n\n2\\. Diagnosed with moderate knee traumatic arthritis (Kellgren-Lawrence classification II or III)(experimental group).\n\nThe control group must not have a diagnosis of osteoarthritis of the knee and must have normal knee joint function.\n\n3\\. Physical Health Status: Able to perform basic movements requiring isometric knee contraction tests and electromyography recording.\n\n4\\. Able to wear knee orthotics.\n\nExclusion Criteria:\n\n* 1\\. Knee or lower extremity injury: Recent (within the past 6 months) history of severe injury, fracture, or surgery to the knee or lower extremity.\n\n  2\\. Other joint disorders: Coexisting joint disorders (such as rheumatoid arthritis or gouty arthritis).\n\n  3\\. Neuromuscular disorders: Presence of neuromuscular dysfunction, such as stroke, Parkinson's disease, or peripheral neuropathy.\n\n  4\\. Uncontrolled cardiovascular disease, hypertension, diabetes, or other medical conditions.\n\nTaking medications that affect neuromuscular function.\n\n5\\. Allergy or intolerance: Allergy to laboratory equipment (such as electromyography electrode gel) or knee brace materials.",true,"ALL","55 Years","75 Years",{"count":46,"type":47},120,"ESTIMATED","INTERVENTIONAL",[50],"NA","This study aims to examine the effects of moderate-intensity strength training, performed with or without an unloading knee orthosis (valgus-corrective or sham mode), on muscle function, motor unit behavior, and force modulation in patients with moderate knee osteoarthritis",[53],"Knee Osteoarthritis (Knee OA)",[55,56],"Orthotic Devices","knee osteoarthritis","NOT_YET_RECRUITING","2026-04-18",{"date":60,"type":61},"2026-04-22","ACTUAL",{"date":63,"type":47},"2026-04-20",{"date":65,"type":47},"2027-12-31",{"name":5,"class":6}]