[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558430":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":27,"centralContacts":31,"locations":24,"responsibleParty":41,"collaborators":24,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":24,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":24,"enrollmentInfo":53,"targetDuration":24,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":66,"whyStopped":24,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":24},{"fullName":5,"class":6},"Newcastle University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nitrate-rich beetroot juice","EXPERIMENTAL","Participants will consume 2 x 70 ml bottles of nitrate-rich beetroot juice for a 7 day period prior to exercise testing",[13],"Dietary Supplement: Nitrate-rich beetroot juice",{"label":15,"type":16,"description":17,"interventionNames":18},"Beetroot juice with nitrate extracted","PLACEBO_COMPARATOR","Participants will consume 2 x 70 ml bottles of beetroot juice with nitrate extracted for a 7 day period prior to exercise testing",[19],"Dietary Supplement: Beetroot juice with nitrate extracted",[21,25],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT",[9],null,{"type":22,"name":15,"description":17,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"affiliation":5,"role":30},"Callum Brownstein, PhD","PRINCIPAL_INVESTIGATOR",[32,37],{"name":29,"role":33,"phone":34,"phoneExt":35,"email":36},"CONTACT","+44 (0)191 208 6000","80568","callum.brownstein@newcastle.ac.uk",{"name":38,"role":33,"phone":39,"phoneExt":24,"email":40},"Guy MacGowan, PhD, MD","(44) 0191 244 8425","guy.macgowan@nhs.net",{"type":30,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Callum Brownstein","Lecturer in Exercise Physiology","100558430","neuromuscular-fatigability-in-individuals-with-heart-failure-100558430",false,"NCT06551012","Neuromuscular Fatigability in Individuals With Heart Failure","The Influence of Active Muscle Mass and Nitrate Supplementation on Fatigability in Individuals With Heart Failure","Inclusion Criteria:\n\n* Patients with a left ventricular ejection fraction \\\u003C 40% who have been diagnosed for at least 3 months.\n* Classified according to New York Heart Association (NYHA) class II-III.\n* Clinically stable and receiving optimal medical treatment.\n* Aged ≥ 45 years old.\n* Ability to read, write and converse in English without the support of an interpreter.\n* Willingness to undertake physical activity with no contraindications to physical activity and capable of performing activities of daily living independently, without the use of a walking aid.\n* Able to provide written informed consent.\n\nExclusion Criteria:\n\n* An electrically implanted device (e.g., pacemaker, left ventricular assist device).\n* Uncontrolled cardiac arrhythmias, myocardial infarction, percutaneous coronary intervention and\u002For bypass graft surgery up to 3 months previously.\n* Receiving antacids or proton pump, xanthine oxidase, or phosphodiesterase inhibitors which affect the reduction of nitrate to nitrite and nitrite to nitric oxide.\n* Treated with organic nitrates (e.g., trinitroglycerin)\n* Major multi-morbidity or other alternative diagnoses of no obvious acute and self-limiting cause (e.g., patients with a terminal diagnosis of cancer, patients in receipt of oxygen therapy or oxygen saturation at rest \\\u003C92%).\n* Obesity (body mass index \\> 30 kg\u002Fm2).\n* Current smoker.\n* Presented with severe symptoms requiring urgent assessment and stabilisation (e.g., breathlessness at rest, hypotension, confusion).\n* Severe physical disability preventing them from functioning independently;\n* Unable to provide informed consent.\n* Currently taking part in any other study.","ALL","45 Years",{"count":54,"type":55},28,"ESTIMATED","INTERVENTIONAL",[58],"NA","Brief summary\n\nThe aims of this project are to 1) characterise muscle fatigue in individuals with chronic heart failure during exercise involving a smaller and larger muscle mass (Part I), 2) to determine the effect of nitrate supplementation on muscle fatigue during large muscle mass exercise in individuals with chronic heart failure (Part II), 3) understand the impact of exercise intolerance on quality of life in individuals with chronic heart failure (Part III). The main questions it aims to answer are:\n\n* Is muscle fatigue attenuated during exercise engaging a smaller vs larger muscle mass in individuals with chronic heart failure owing to lower central cardiopulmonary constraints?\n* Can supplementation with nitrate-rich beetroot juice reduce muscle fatigue and\u002For accelerate post-exercise recovery of muscle function in response to whole body exercise in individuals with heart failure?\n* What impact does exercise intolerance have on the lives of individuals with chronic heart failure?\n\nFor Part I, researchers will compare muscle fatigue during single- and double-leg incremental cycling in individuals with chronic heart failure.\n\nFor Part II, researchers will compare muscle fatigue in individuals with chronic heart failure during double-leg incremental cycling following a period of beetroot juice supplementation containing nitrate, or with a placebo drink consisting of beetroot juice with nitrate extracted.\n\nFor Part III, semi-structured interviews will be conducted to investigate the symptoms associated with performing physical activity and on the impact of exercise intolerance on quality of life in individuals with chronic heart failure.",[61],"Heart Failure With Reduced Ejection Fraction",[63,64,65],"Exercise","Physiology","Fatigability","NOT_YET_RECRUITING","2025-03-24",{"date":69,"type":70},"2025-03-25","ACTUAL",{"date":72,"type":55},"2025-05-01",{"date":74,"type":55},"2027-04-01",{"name":5,"class":6}]