[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644602":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":30,"centralContacts":37,"locations":44,"responsibleParty":63,"collaborators":30,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":30,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":30,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":47,"whyStopped":30,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of British Columbia","OTHER",[8,14,18,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Ring-Mode Stimulation","EXPERIMENTAL","Participants receive DBS ring-mode stimulation, allowing current to spread across the target region encompassing the ventral posteromedial nucleus (VPM), anterior pulvinar (aPu), and centromedian nucleus (CM).",[13],"Device: Directional Deep Brain Stimulation",{"label":15,"type":10,"description":16,"interventionNames":17},"Ventral Posteromedial Nucleus (VPM) Stimulation","Participants receive directional DBS stimulation targeted toward the ventral posteromedial nucleus (VPM) of the thalamus.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Anterior Pulvinar (aPu) Stimulation","Participants receive directional DBS stimulation targeted toward the anterior pulvinar (aPu) of the thalamus.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Centromedian Nucleus (CM) Stimulation","Participants receive directional DBS stimulation targeted toward the centromedian nucleus (CM) of the thalamus.",[13],{"label":27,"type":28,"description":29,"interventionNames":30},"Stimulation Off","NO_INTERVENTION","Participants have the DBS device turned off and serve as a control condition for comparison with active stimulation settings.",null,[32],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":30},"DEVICE","Directional Deep Brain Stimulation","Participants will receive standard-of-care directional deep brain stimulation (DBS) using an implanted DBS system. Stimulation will be delivered using ring-mode stimulation, directional stimulation toward the ventral posteromedial nucleus (VPM), anterior pulvinar (aPu), or centromedian nucleus (CM), or with stimulation turned off. Participants will undergo each stimulation condition in a randomized sequence.",[19,23,9,15],[38],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Danielle Pietramala","CONTACT","604-875-4111","68396","danielle.pietram@ubc.ca",[45],{"facility":46,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Vancouver General Hospital","RECRUITING","Vancouver","British Columbia","V5Z1M9","Canada","CA",{"type":54,"coordinates":55},"Point",[56,57],-123.11934,49.24966,{"lat":57,"lon":56},[60],{"name":39,"role":40,"phone":61,"phoneExt":30,"email":62},"6043495059","d.pietramala@hotmail.com",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Christopher Honey","N","100644602","neuropathic-dental-pain--dbs-100644602",false,"NCT07671950","Neuropathic Dental Pain & DBS","Pain Alleviation for Patients Receiving Directional Deep Brain Stimulation to Treat Neuropathic Dental Pain","Inclusion Criteria:\n\n* Age 19 to 80 years.\n* Diagnosis of Atypical Odontalgia (AO) (also known as neuropathic dental pain).\n* Receiving deep brain stimulation (DBS) treatment for AO due to inadequate response to conventional therapies, including: Pharmacological therapies, and\u002For Local anesthetics, corticosteroid injections, or nerve blocks.\n* Able and willing to provide informed consent.\n\nExclusion Criteria:\n\n* Refusal or inability to provide informed consent.\n* Known major depression.\n* Acute psychosis.","ALL","19 Years","80 Years",{"count":78,"type":79},5,"ESTIMATED","INTERVENTIONAL",[82],"NA","This prospective observational study will evaluate pain outcomes in patients with neuropathic dental pain (Atypical Odontalgia\u002FPhantom Tooth Pain) who undergo directional deep brain stimulation (DBS). Participants will complete validated pain, disability, quality-of-life, and mood assessments before surgery and following DBS programming. Directional stimulation will be applied to different thalamic targets to determine whether specific stimulation settings are associated with greater pain relief. The study aims to characterize changes in pain and quality of life following DBS and to identify the stimulation target associated with the greatest reduction in neuropathic dental pain.",[85,86],"Dental Neuralgia","Neuropathic Dental Pain",[86,85,88],"Deep Brain Stimulation","2026-06-22",{"date":91,"type":92},"2026-06-26","ACTUAL",{"date":94,"type":92},"2026-01-01",{"date":96,"type":79},"2028-01-01",{"name":5,"class":6},1]