[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592512":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":37,"centralContacts":42,"locations":48,"responsibleParty":66,"collaborators":70,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":76,"sex":82,"minAge":83,"maxAge":36,"enrollmentInfo":84,"targetDuration":36,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":95,"overallStatus":99,"whyStopped":36,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Hospital da Polícia Militar de Goiás","NETWORK",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Anodal tdcs over the primary motor (M1)","ACTIVE_COMPARATOR","Anode placement will be positioned over M1, using the international 10-20 EEG system (C3\u002FC4 for left or right M1).\n\nCathode placement will be on the contralateral supraorbital area (above the eyebrow) to complete the circuit.",[13],"Device: tDCS",{"label":15,"type":10,"description":16,"interventionNames":17},"Anodal tdcs over the dorsolateral prefrontal cortex (DLPFC)","Anode placement positioned over dorsolateral prefrontal cortex (DLPFC), using the international 10-20 EEG system (F3\u002FF4 for left or right DLPFC).\n\nCathode placement will be on the contralateral supraorbital area (above the eyebrow) to complete the circuit.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"sham tdcs over M1 or DLPFC","SHAM_COMPARATOR","The sham group will be divided in half of participants with Sham M1 and the other half as Sham DLPFC.",[23],"Device: sham intervention",[25,32],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","tDCS","This group will receive single-phase direct current with an intensity of 2 mA up. Electrodes with a size of 35cm² (5 x 7 centimeters) will be used. Electrodes will be placed on the scalp, fixed with elastic bands, and immersed in 10 to 12 mL of saline solution.",[15,9],[31],"transcranial direct current stimulation",{"type":26,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"sham intervention","The device displays will be identical across active and sham groups, and to ensure blinding, an active current will be applied for 30 seconds at the beginning and end of the sham stimulation to mimic the sensation of the current ramp experienced in active stimulation. Stimulations of less than 3 minutes of tDCS do not induce cortical excitability effects, according to Nitsche and Paulus (2000), being safely inactive for the expected results.",[19],null,[38],{"name":39,"affiliation":40,"role":41},"Clarissa Bueno, MD, PhD","São Paulo University","STUDY_DIRECTOR",[43],{"name":44,"role":45,"phone":46,"phoneExt":36,"email":47},"Eline RF Barbosa, MD, MD","CONTACT","+5562981787456","elinebarbosa@gmail.com",[49],{"facility":5,"status":36,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Goiânia","Goiás","74423-120","Brazil","BR",{"type":56,"coordinates":57},"Point",[58,59],-49.25389,-16.67861,{"lat":59,"lon":58},[62],{"name":63,"role":45,"phone":64,"phoneExt":36,"email":65},"Eline RF Barbosa, MD","+55623235-6223","hpm@hpm.org.br",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"PRINCIPAL_INVESTIGATOR","Eline Rozária Ferreira Barbosa","Principal Investigator",[71],{"name":72,"class":73},"Hospital das Clínicas de São Paulo - SP","UNKNOWN","100592512","neuropathic-pain-intervention-with-tdcs-in-brazilian-military-personnel-neubrain-trial-100592512",false,"NCT06994390","Neuropathic Pain Intervention With tDCS in Brazilian Military Personnel (NeuBRAIN Trial)","Neuropathic Pain Intervention With tDCS in Brazilian Military Personnel Randomized Controlled Trial","NeuBRAIN","Inclusion criteria:\n\n* Military personnel (active and veterans) with chronic pain due to central or peripheral neuropathy and poor sleep quality;\n* Age over 18 years old;\n* Defined chronic NeP according to current guidelines (ICD-10 codes OR DN-4);\n* Pain with an average intensity score above 40\u002F100 mm on a visual analogue scale (VAS);\n* Medication stability (chronic pain, depression, anxiety, sleep) for at least six weeks;\n* Patients with bad sleep quality identified by the Pittsburgh Sleep Quality Index (PSQI) of 5 or more who do not improve under conventional treatment.\n\nExclusion criteria:\n\n* General contraindications for tDCS: past head trauma, current epilepsy, intracranial ferromagnetic components, pacemaker, implanted microprocessors (i.e., cochlear implants);\n* Pregnancy;\n* Known major psychiatric disorders (as assessed by the DSM-5, e.g., psychosis), history of substance abuse, or work litigation issues;\n* History of chronic refractory migraines;\n* Non-treated moderate to severe sleep apnea defined as apnea\u002Fhypopnea index greater than 15 events per hour in baseline polysomnography;\n* Skin conditions such as psoriasis or eczema that involve the scalp (Thair et al, 2017);\n* Cancer-related pain;\n* BMI \\>35, due to increased reports of pain associated with increased BMI (Basem, et al., 2021; Stokes et al., 2020);\n* Patients who do not sign informed consent or do not want to participate in the study.","ALL","18 Years",{"count":85,"type":86},120,"ESTIMATED","INTERVENTIONAL",[89],"NA","This project protocol investigates the efficacy of transcranial direct current stimulation (tDCS) in treating neuropathic pain and improving sleep quality among Brazilian military personnel. Given the high prevalence of chronic pain and sleep disturbances in this population, and the limitations of current pharmacological treatments, our randomized, triple-blinded, sham-controlled trial explores the potential of tDCS as a non-invasive therapeutic intervention. The results of this study could have a significant impact on improving the well-being and performance of military personnel, while also reducing healthcare costs associated with long-term medication use.",[92,93,94],"Neuropathic Pain","Sleep Quality","Transcranial Direct Current Stimulation",[96,97,98],"transcranial current stimulation","neuropathic pain","sleep","NOT_YET_RECRUITING","2025-05-25",{"date":102,"type":103},"2025-05-29","ACTUAL",{"date":105,"type":86},"2026-03-01",{"date":107,"type":86},"2030-03-01",{"name":5,"class":6},1]