[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616536":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":35,"centralContacts":40,"locations":46,"responsibleParty":65,"collaborators":10,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":10,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":10,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":93,"whyStopped":10,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14,18],{"label":9,"type":6,"description":10,"interventionNames":11},"Diabetic patients with symptomatic peripheral neuropathy.",null,[12,13],"Diagnostic Test: Nerve conduction study","Diagnostic Test: Nerve ultrasound",{"label":15,"type":6,"description":10,"interventionNames":16},"Diabetic without any clinical features nor complaints of peripheral neuropathy",[12,13,17],"Diagnostic Test: Autonomic assessment",{"label":19,"type":6,"description":10,"interventionNames":20},"Healthy individuals.",[12,13,17],[22,27,31],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DIAGNOSTIC_TEST","Nerve conduction study","Nerve conduction studies (NCS) are widely regarded as the gold standard for evaluating large-fiber peripheral nerve function. They measure conduction velocity, latency, and amplitude, providing objective evidence of axonal loss or demyelination. While highly specific, NCS often detect abnormalities only in established diabetic peripheral neuropathy, limiting their sensitivity for early or subclinical disease.",[9,15,19],{"type":23,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Nerve ultrasound","High-resolution ultrasound (HRUS) is a non-invasive imaging tool that allows structural evaluation of peripheral nerves. It can measure cross-sectional area (CSA), visualize fascicular pattern, and detect nerve enlargement or structural abnormalities. In diabetic peripheral neuropathy, HRUS provides complementary information to functional tests and may identify early or subclinical changes.",[9,15,19],{"type":23,"name":32,"description":33,"armGroupLabels":34,"otherNames":10},"Autonomic assessment","Autonomic testing provides insight into small-fiber and autonomic nervous system function, often impaired early in diabetic peripheral neuropathy. Heart rate variability (HRV) during deep breathing and postural change is a simple, non-invasive method to detect cardiovascular autonomic dysfunction",[15,19],[36],{"name":37,"affiliation":38,"role":39},"Nageh Fouly","Department of Neurology , Assiut University, Egypt","STUDY_CHAIR",[41],{"name":42,"role":43,"phone":44,"phoneExt":10,"email":45},"Dalia Galal","CONTACT","+201090463145","daliarageh6@gmail.com",[47],{"facility":48,"status":10,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Department of Neurology, Faculty of Medicine,Assiut university","Asyut","Asyut Governorate","71511","Egypt","EG",{"type":55,"coordinates":56},"Point",[57,58],31.18368,27.18096,{"lat":58,"lon":57},[61],{"name":62,"role":43,"phone":63,"phoneExt":10,"email":64},"Ahmed Hamed","+201011144391","dahmed.hamed@aun.edu.eg",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dalia Rageh Daifallah Galal","Resident at Neurology and Psychiatry Department, Assiut University","100616536","neurophysiological-autonomic-and-sonographic-assessment-of-diabetic-peripheral-neuropathy-100616536",false,"NCT07306884","Neurophysiological, Autonomic, and Sonographic Assessment of Diabetic Peripheral Neuropathy","Inclusion Criteria:\n\nAdults aged 18-75 years with type 1 or type 2 diabetes (with or without diabetic peripheral neuropathy), and age and sex-matched healthy controls\n\nExclusion Criteria:\n\n* Other causes of neuropathy (e.g., CIDP, trauma, toxins, vitamin deficiencies), advanced renal failure,thyroid disease,chronic alcohol use, pregnancy,\n* presence of implanted cardiac devicesthat may interfere with autonomic testing",true,"ALL","18 Years","75 Years",{"count":80,"type":81},75,"ESTIMATED","INTERVENTIONAL",[84],"NA","Diabetic peripheral neuropathy causes pain, sensory loss, and foot risk; multimodal assessment enables earlier diagnosis and improved patient management.",[87,88],"Diabete Mellitus","Peripheral (Sensorimotor) Diabetic Polyneuropathy",[87,90,91,28,92],"Peripheral neuropathy","Neurophysiological studies","automatic assessment","NOT_YET_RECRUITING","2025-12-13",{"date":96,"type":97},"2025-12-29","ACTUAL",{"date":99,"type":81},"2026-01",{"date":101,"type":81},"2027-02",{"name":5,"class":6},1]