[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100549336":3},{"organization":4,"armGroups":7,"interventions":32,"overallOfficials":11,"centralContacts":43,"locations":11,"responsibleParty":52,"collaborators":11,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":11,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":11,"overallStatus":76,"whyStopped":11,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":11},{"fullName":5,"class":6},"University Medical Center Groningen","OTHER",[8,14,18,21,26,29],{"label":9,"type":10,"description":11,"interventionNames":12},"sham stimulation of the tibialis anterior","SHAM_COMPARATOR",null,[13],"Device: Transcutaneous Electrical Nerve Stimulation",{"label":15,"type":16,"description":11,"interventionNames":17},"active stimulation of the tibialis anterior","EXPERIMENTAL",[13],{"label":19,"type":16,"description":11,"interventionNames":20},"active stimulation of the quadriceps",[13],{"label":22,"type":23,"description":11,"interventionNames":24},"continuous movement of the foot (plantar & dorsiflexion)","ACTIVE_COMPARATOR",[25],"Behavioral: Movement",{"label":27,"type":10,"description":11,"interventionNames":28},"a combination of sham stimulation of the tibialis anterior and movement of the foot",[13,25],{"label":30,"type":16,"description":11,"interventionNames":31},"a combination of active stimulation of the tibialis anterior and movement of the foot",[13,25],[33,38],{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":11},"DEVICE","Transcutaneous Electrical Nerve Stimulation","Transcutaneous electrical nerve stimulation (TENS) is a safe, relatively cheap, and non-painful stimulation of the peripheral sensory and motor nerves. The stimulator is easy to operate and pwMS can apply the stimulation themselves at home. This makes TENS an interesting tool to augment sensory input. A high frequency and long pulse duration is used.",[30,27,19,15,9],{"type":39,"name":40,"description":41,"armGroupLabels":42,"otherNames":11},"BEHAVIORAL","Movement","Participants are instructed to perform plantar- and dorsi-flexion contraction in a relatively slow tempo. The movement of the ankle is measured by an MRI-compatible potentiometer and participants receive feedback of this movement on the screen inside the scanner.",[30,27,22],[44,49],{"name":45,"role":46,"phone":47,"phoneExt":11,"email":48},"Nikki Dreijer","CONTACT","0625647172","n.dreijer@umcg.nl",{"name":50,"role":46,"phone":11,"phoneExt":11,"email":51},"Inge Zijdewind","c.a.t.zijdewind@umcg.nl",{"type":53,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100549336","neurophysiological-effects-of-transcutaneous-electrical-nerve-stimulation-in-persons-with-ms-100549336",false,"NCT06432686","Neurophysiological Effects of Transcutaneous Electrical Nerve Stimulation in Persons With MS","Neurophysiological Effects of Transcutaneous Electrical Nerve Stimulation in Persons With MS - a Pilot Study","Inclusion Criteria:\n\n* age: 18-65 years\n* EDSS score \\\u003C 7\n\nExclusion Criteria:\n\n* metal or electrical implants\n* BMI \\> 40\n* claustrophobia\n* being pregnant\n* having a psychiatric disorder\n* having cognitive or communication problems which reduces the capacity to understand instructions\n* having a neurological disorder other than MS\n* having cardiac arrhythmia",true,"ALL","18 Years","65 Years",{"count":66,"type":67},30,"ESTIMATED","INTERVENTIONAL",[70],"NA","Transcutaneous Electrical Nerve Stimulation (TENS) is a treatment that could potentially reduce walking problems and fatigue in persons with Multiple Sclerosis. However, extensive use of TENS in a clinical setting is hindered by a lack of neurophysiological understanding of the effects of TENS. The primary objective of this pilot study is therefore to investigate the effects of TENS on brain activity in pwMS measured with fMRI.",[73,74,75],"Fatigue","Walking, Difficulty","Multiple Sclerosis","NOT_YET_RECRUITING","2025-09-03",{"date":79,"type":80},"2025-09-10","ACTUAL",{"date":82,"type":67},"2025-10-01",{"date":84,"type":67},"2025-12-31",{"name":5,"class":6}]