[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552287":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":30,"responsibleParty":45,"collaborators":47,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":20,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":20,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":20,"overallStatus":33,"whyStopped":20,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"University of Wisconsin, Madison","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental word-learning task for aphasia","EXPERIMENTAL","The word learning task includes 210 trials across 7 learning blocks (30 trials\u002Fblock). Each trial features two novel objects (target and foil) on the screen, with an audio recording naming one object. Subjects must quickly and accurately identify the named object. Correct responses are rewarded with a happy face, and incorrect ones with a sad face. The target object's position is counter-balanced, and trial order is randomized for each subject. Short pauses occur every 60 trials to reduce fatigue. After 7 learning blocks, feedback is discontinued, and an immediate test block assesses word-referent recognition. A week later, a second test block, with the same instructions, measures retained learning. Each test block consists of 30 randomized trials without feedback.",[13],"Behavioral: Pseudoword learning paradigm task",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Pseudoword learning paradigm task","Pseudoword learning is an experimental learning task by which participants view two novel objects (a target and a foil) and simultaneously hear an audio recording of the pseudoword name of one of the two objects. Participants must choose (via mouse click) which object corresponds to the word presented, immediately after which feedback is provided.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Haley Dresang, PhD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","(608) 890-0628","hdresang@wisc.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":20},"UW School of Medicine and Public Health","RECRUITING","Madison","Wisconsin","53792","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-89.40123,43.07305,{"lat":43,"lon":42},{"type":46,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[48,51],{"name":49,"class":50},"National Institutes of Health (NIH)","NIH",{"name":52,"class":50},"National Institute on Deafness and Other Communication Disorders (NIDCD)","100552287","neuroplasticity-biomarkers-in-aphasia-100552287",false,"NCT06471127","Neuroplasticity Biomarkers in Aphasia","Genetic and MRI Biomarkers of Neuroplasticity Predict Aphasia Recovery and Phenotypes","Inclusion Criteria:\n\n1. Ages 40-90\n2. Right-handed (prior to stroke)\n3. Proficient English speakers\n4. History of a single ischemic stroke in the middle cerebral artery territory that is lateralized to the left or right (Aim 1) cerebral hemisphere.\n5. Presence of aphasia (Aims 2-3)\n6. Capacity to understand the nature of the study and provide informed consent\n7. Acute or subacute stroke at the time of Aim 1 enrollment; Stroke #12 months old (chronic) at the time of Aims 2-3 enrollment\n8. Medically stable\n\nExclusion Criteria:\n\n1. History of significant medical or neurological disorder (other than stroke)\n2. History of significant or poorly controlled psychiatric disorders\n3. Current abuse of alcohol or drugs, prescription or otherwise\n4. Clinically significant and uncorrected vision or hearing loss\n5. Anything other than standard of care stroke treatment such as Plavix, aspirin (81-300 mg daily), beta-blockers, diabetes medications or choles- terol-lowering agents, thrombolytics (e.g., tPA), anticoagulation agents such as Heparin, Warfarin\u002FCoumadin","ALL","40 Years","90 Years",{"count":64,"type":65},90,"ESTIMATED","INTERVENTIONAL",[68],"NA","Patients with stroke frequently suffer from aphasia, a disorder of expressive and\u002For receptive language, that can lead to serious health consequences, including social isolation, depression, reduced quality of life, and increased caregiver burden. Aphasia recovery varies greatly between individuals, and likely relies upon the capacity for neuroplasticity, both at a systems level of reorganized brain networks and a molecular level of neuronal repair and plasticity. The proposed work will evaluate genetic and neural network biological markers of neuroplasticity associated with variability in aphasia, with a future goal to improve prognostics and identify therapeutic targets to reduce the long-term burdens of aphasia.",[71,72,73],"Aphasia","Language","Stroke","2025-10-21",{"date":76,"type":77},"2025-10-23","ACTUAL",{"date":79,"type":77},"2025-03-17",{"date":81,"type":65},"2029-05-31",{"name":5,"class":6},1]