[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618821":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":39,"centralContacts":43,"locations":52,"responsibleParty":87,"collaborators":38,"id":90,"slug":91,"hasResults":92,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":92,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":38,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":119,"whyStopped":38,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":129},{"fullName":5,"class":6},"Charles University, Czech Republic","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"Sequence A","EXPERIMENTAL","Participants first receive NEUROEQUIP-SMA (Equine-Assisted Physiotherapy Based on Neuro-proprioceptive Facilitation and Inhibition) for six consecutive days, followed by a washout period of 6 weeks to 3 months, and then Standard Individual Outpatient Physiotherapy Based on Neuro-proprioceptive Facilitation and Inhibition (SMA-SOC-N) for six consecutive days. Each phase includes standardized Therapeutic Grooming.",[13,14,15],"Behavioral: Equine-Assisted Physiotherapy based on Neuro-proprioceptive \"Facilitation and Inhibition\"","Behavioral: Standard Individual Outpatient Physiotherapy Based on Neuro-proprioceptive Facilitation and Inhibition","Behavioral: Therapeutic grooming",{"label":17,"type":10,"description":18,"interventionNames":19},"Sequence B","Participants first undergo six days of standard individual outpatient physiotherapy based on neuro-proprioceptive facilitation and inhibition (SMA-SOC-N), followed by a washout period of 6-12 weeks, and then six days of equine-assisted physiotherapy based on neuro-proprioceptive facilitation and inhibition (NEUROEQUIP-SMA). Each phase includes a standardized therapeutic grooming component.",[13,14,15],[21,28,34],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Equine-Assisted Physiotherapy based on Neuro-proprioceptive \"Facilitation and Inhibition\"","Equine-assisted physiotherapy applying the principles of neuro-proprioceptive facilitation and inhibition. Conducted twice daily for 15 minutes over six consecutive days under the supervision of a certified physiotherapist and a trained horse leader. The intervention utilizes the horse's rhythmic, three-dimensional movement to generate dynamic proprioceptive, vestibular, and tactile stimuli that activate physiological postural reactions and coordinated muscle chains. The goal is to improve trunk stability, breathing control, movement symmetry, and functional motor coordination in children with spinal muscular atrophy. The therapy is delivered in a controlled equine environment, using manual facilitation and specific body positioning to modulate neuronal excitability and enhance neuromuscular function.",[9,17],[27],"NEUROEQUIP-SMA",{"type":22,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Standard Individual Outpatient Physiotherapy Based on Neuro-proprioceptive Facilitation and Inhibition","Standardized outpatient physiotherapy program based on neuro-proprioceptive facilitation and inhibition, performed once daily for 30 minutes over six consecutive days. Delivered by an experienced physiotherapist in a clinical setting, the intervention includes active and assisted movement exercises, breathing techniques, stretching, postural correction, and positioning strategies to prevent contractures, maintain range of motion, and support trunk and respiratory control. The therapy applies targeted afferent stimuli to modulate motoneuron excitability and improve voluntary activation of motor units. The approach follows international standards of SMA rehabilitation, focusing on optimizing postural alignment, movement efficiency, and overall motor performance.",[9,17],[33],"SMA-SOC-N",{"type":22,"name":35,"description":36,"armGroupLabels":37,"otherNames":38},"Therapeutic grooming","Structured horse-care activity included in both treatment periods to control for psychosocial and environmental effects of horse interaction. Conducted once daily for approximately 20 minutes under therapist supervision, therapeutic grooming involves guided brushing, tactile contact, and communication with the horse in a safe and supportive setting. The activity promotes sensory integration, body awareness, and emotional regulation, while preparing the child for subsequent equine-assisted sessions. Although not a primary therapeutic modality, it standardizes the environmental exposure across study arms and supports comfort, motivation, and engagement in children participating in physiotherapeutic interventions.",[9,17],null,[40],{"name":41,"affiliation":5,"role":42},"Katerina Marikova, master","PRINCIPAL_INVESTIGATOR",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":38,"email":48},"Kamila Rasova, professor","CONTACT","+420 604 511 416","kamila.rasova@lf3.cuni.cz",{"name":41,"role":46,"phone":50,"phoneExt":38,"email":51},"+420 607 616 104","katerina.marikova@3lf.cuni.cz",[53,64,73,82],{"facility":54,"status":38,"city":55,"state":38,"zip":56,"country":57,"countryCode":38,"cosmosGeoPoint":58,"geoPoint":63,"contacts":38},"Mirákl Hippotherapy Center","Bohuslavice","58856","Czechia",{"type":59,"coordinates":60},"Point",[61,62],18.12866,49.94232,{"lat":62,"lon":61},{"facility":65,"status":38,"city":66,"state":38,"zip":67,"country":57,"countryCode":38,"cosmosGeoPoint":68,"geoPoint":72,"contacts":38},"College of Polytechnics Jihlava","Jihlava","58601",{"type":59,"coordinates":69},[70,71],15.59124,49.3961,{"lat":71,"lon":70},{"facility":74,"status":38,"city":75,"state":38,"zip":76,"country":57,"countryCode":38,"cosmosGeoPoint":77,"geoPoint":81,"contacts":38},"Department of Medical Genetics, Third Faculty of Medicine, Charles University","Prague","10000",{"type":59,"coordinates":78},[79,80],14.42076,50.08804,{"lat":80,"lon":79},{"facility":83,"status":38,"city":75,"state":38,"zip":76,"country":57,"countryCode":38,"cosmosGeoPoint":84,"geoPoint":86,"contacts":38},"Third Faculty of Medicine, Charles University",{"type":59,"coordinates":85},[79,80],{"lat":80,"lon":79},{"type":42,"investigatorFullName":88,"investigatorTitle":89,"investigatorAffiliation":5,"oldNameTitle":38,"oldOrganization":38},"Kamila Řasová","proffesor","100618821","neuroproprioceptive-equine-assisted-physiotherapy-for-spinal-muscular-atrophy-100618821",false,"NCT07336602","Neuroproprioceptive Equine-Assisted Physiotherapy for Spinal Muscular Atrophy","Immediate and Sustained Effects of Intensive Neuroproprioceptive Equine-Assisted Physiotherapy in Children With Spinal Muscular Atrophy: A Randomized Crossover Trial","NEUROEQUIP","Inclusion Criteria:\n\n* Age between 2 and 9 years\n* Clinical diagnosis of spinal muscular atrophy (SMA) type I, II, or III\n* Stable health condition for at least 6 months prior to enrollment\n* Ability to participate in the study procedures\n* Written informed consent provided by a parent or legal guardian\n\nExclusion Criteria:\n\n* Hip dislocation\n* Known allergy to horses or the stable environment\n* Severe fear of horses that would prevent participation in equine-assisted physiotherapy\n\nAny other medical condition that, in the investigator's opinion, would interfere with safe participation in the study","ALL","2 Years","9 Years",{"count":102,"type":103},20,"ESTIMATED","INTERVENTIONAL",[106],"NA","This study investigates whether Equine-Assisted Physiotherapy based on Neuro-proprioceptive \"Facilitation and Inhibition\" (NEUROEQUIP-SMA) can improve movement, posture, breathing, and quality of life in children with spinal muscular atrophy (SMA). This therapy uses the horse's rhythmic movement together with targeted sensory and manual stimulation to trigger natural motor reactions starting from the pelvis, lower the threshold for muscle activation, and support coordinated motor patterns. The study compares this method with standard individual physiotherapy based on the same neuro-proprioceptive facilitation and inhibition principles, but performed without the horse. Twenty children aged 2 to 9 years will receive both therapies in two separate 6-day blocks, in random order (crossover design). The researchers will assess muscle fatigue, coordination, breathing function, movement quality and quantity, quality of life, and changes in selected blood biomarkers. The results may help develop better rehabilitation strategies for children with SMA who are receiving modern pharmacological or gene therapy.",[109],"Spinal Muscular Atrophy (SMA)",[111,112,113,114,115,116,117,118],"Muscular atrophy, Spinal","Genetic Therapy","Equine-Assisted Therapy","Child","Pediatrics","Physical Therapy Modalities","RNA, Long Noncoding","Neuro-proprioceptive Principles","NOT_YET_RECRUITING","2025-12-30",{"date":122,"type":123},"2026-01-13","ACTUAL",{"date":125,"type":103},"2026-04-15",{"date":127,"type":103},"2026-06-30",{"name":5,"class":6},4]