[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552447":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":38,"locations":44,"responsibleParty":61,"collaborators":64,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":63,"enrollmentInfo":77,"targetDuration":63,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":46,"whyStopped":63,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Remote ischemic post-conditioning (RIPOST)","EXPERIMENTAL","Patients subjected to three sessions of RIPOST (within the 4 hours following cardiac arrest and then 12 and 24 hours after cardiac arrest)",[13],"Other: Remote ischemic post conditioning sessions",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham procedure","SHAM_COMPARATOR","Patients subjected to three sessions of a sham procedure (within the 4 hours following cardiac arrest and then 12 and 24 hours after cardiac arrest)",[19],"Other: Sham sessions",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Remote ischemic post conditioning sessions","Three sessions of RIPOST (within the 4 hours following cardiac arrest and then 12 and 24 hours after cardiac arrest), as follows: four cycles of cuff inflation to 200 mmHg for 5 min and then deflation to 0 mmHg for another 5 min (40 min total duration of the intervention), using an inflatable thigh tourniquet",[9],[26],"RIPOST",{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Sham sessions","Three sessions of a sham procedure (within the 4 hours following cardiac arrest and then 12 and 24 hours after cardiac arrest), as follows : application of a thigh tourniquet during 40 min without any inflation",[15],[32],"Sham",[34],{"name":35,"affiliation":36,"role":37},"Chelly Jonathan, MD","Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer","STUDY_DIRECTOR",[39],{"name":35,"role":40,"phone":41,"phoneExt":42,"email":43},"CONTACT","0494145124","+33","Jonathan.chelly@ch-toulon.fr",[45],{"facility":36,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Toulon","Var","83100","France","FR",{"type":53,"coordinates":54},"Point",[55,56],5.92836,43.12442,{"lat":56,"lon":55},[59],{"name":60,"role":40,"phone":41,"phoneExt":42,"email":43},"Jonathan Chelly, MD",{"type":62,"investigatorFullName":63,"investigatorTitle":63,"investigatorAffiliation":63,"oldNameTitle":63,"oldOrganization":63},"SPONSOR",null,[65],{"name":66,"class":6},"French Society for Intensive Care","100552447","neuroprotective-effect-of-remote-ischemic-post-conditioning-in-out-of-hospital-cardiac-arrest-100552447",false,"NCT06473207","Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest","Neuroprotective Effect of Remote Ischemic Post-conditioning in Out-of-hospital Cardiac Arrest : a Randomized Open Label Controlled Trial","RIPOST-CA","Inclusion Criteria:\n\n* Out-of-hospital cardiac arrest with stable return of spontaneous circulation (ROSC \\> 20 minutes)\n* Patient receiving invasive mechanical ventilation for coma (Glasgow score \\\u003C 8)\n* Availability of a lower limb without intravenous infusion or tension cuff positioned on it\n* Randomization and application of the first session of the tested procedure within 4 hours after ROSC\n* Consent of a next-of-kin or inclusion in emergency procedure\n\nExclusion criteria :\n\n* Age \\\u003C 18 y.o or pregnancy\n* Patient unable to walk without assistance, unable to support himself properly without assistance, bedridden, incontinent and requiring nursing constant attention and care (corresponding to a mRS equal to 4 or 5)\n* Interval between cardiac arrest and ROSC (no flow + low flow) estimated \\> 60 minutes\n* Unwitnessed cardiac arrest with asystole as first rhythm\n* In-hospital cardiac arrest\n* Refractory cardiac arrest (no ROSC considered as stable)\n* Cardiac arrest from traumatic, hemorrhage, stroke or hanging supposed origin\n* Mean arterial pressure \\\u003C 65mmHg persisting despite appropriate vascular filling and vasopressor and\u002For inotropic support\n* Active uncontrolled bleeding\n* Contraindication or not possible to use a pneumatic tourniquet on none of the two lower limbs (amputations, intravenous infusion positioned on both lower limbs, tourniquet size incompatible with patient morphology)\n* Implementation of extracorporeal arteriovenous circulation for refractory cardiac arrest or refractory cardiogenic shock before inclusion\n* Patient already included in this study\n* Inclusion in another interventional study which purpose is to improve prognosis after a cardiac arrest\n* Judicial protection measure\n* Patient without French social security","ALL","18 Years",{"count":78,"type":79},48,"ESTIMATED","INTERVENTIONAL",[82],"NA","Patients admitted to intensive care unit (ICU) following an out-of-hospital cardiac arrest (OHCA) have a high morbidity and mortality rate, primarily due to ischemia-reperfusion (I\u002FR) syndrome leading to anoxic-ischemic brain injury. Despite current recommended advanced life support therapies, no specific treatment or procedure has yet been shown to improve the neurological outcome of such patients.\n\nRemote ischemic post-conditioning (RIPOST) which usually consists of applying brief and repeated cycles of ischemia alternating with reperfusion by inflating and deflating a blood pressure cuff or a pneumatic tourniquet placed around a limb, is a promising strategy to protect organs against I\u002FR injury, including brain. Regarding cardiac arrest, pre-clinical studies have demonstrated an improvement in neurological outcome in animal subjects treated with RIPOST after cardiopulmonary resuscitation.\n\nThe aim of our study is to demonstrate the benefit of early RIPOST in OHCA patients in reducing neurological injury and organ failure related to I\u002FR syndrome.",[85],"Out-Of-Hospital Cardiac Arrest",[87,88,89,90],"Remote ischemic conditioning","Out-of-hospital cardiac arrest","Neuroprotection","Cardiac arrest","2026-06-15",{"date":93,"type":94},"2026-06-16","ACTUAL",{"date":96,"type":94},"2025-01-11",{"date":98,"type":79},"2028-04",{"name":5,"class":6},1]