[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575172":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":27,"locations":32,"responsibleParty":46,"collaborators":48,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":76,"overallStatus":34,"whyStopped":11,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Yale University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Remote physical exercise","EXPERIMENTAL",null,[13],"Other: Lactulose Oral Product",{"label":15,"type":16,"description":11,"interventionNames":17},"Control physical exercise","ACTIVE_COMPARATOR",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"Lactulose Oral Product","Each arm will undergo a study to induce colonic fermentation through lactulose at the beginning and at the end of the 12 weeks.",[15,9],[24],{"name":25,"affiliation":5,"role":26},"NICOLA SANTORO, MD, PhD","PRINCIPAL_INVESTIGATOR",[28],{"name":25,"role":29,"phone":30,"phoneExt":11,"email":31},"CONTACT","2037852819","nicola.santoro@yale.edu",[33],{"facility":5,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":11},"RECRUITING","New Haven","Connecticut","06520","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-72.92816,41.30815,{"lat":44,"lon":43},{"type":47,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR",[49,52],{"name":50,"class":51},"National Institutes of Health (NIH)","NIH",{"name":53,"class":51},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","100575172","new-mechanisms-of-obesity-100575172",false,"NCT06768827","New Mechanisms of Obesity","Pathogenic Mechanisms of Obesity and Its Cardiometabolic Complications","NMoO","Inclusion Criteria:\n\n* Age 15 to 22 years\n* In puberty (girls and boys: Tanner stage III-V);\n* BMI \\>85th\n\nExclusion Criteria:\n\n* Pregnancy;\n* endocrinopathies (e.g., Cushing syndrome);\n* substance abuse;\n* medications affecting insulin resistance such as metformin, GLP-1 analogues; -\n* high fibers intake (\\> 30g\u002Fday) as assessed by a 3-day food record.","ALL","15 Years","22 Years",{"count":66,"type":67},55,"ESTIMATED","INTERVENTIONAL",[70],"NA","Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulating metabolism in youth with obesity.",[73,74,75],"Obesity and Overweight","Insulin Resistance","Obesity and Obesity-related Medical Conditions",[77,78,74,79],"Obesity","Youth","Intestinal Fermentation","2026-01-26",{"date":82,"type":83},"2026-01-28","ACTUAL",{"date":85,"type":83},"2025-11-13",{"date":87,"type":67},"2030-03-31",{"name":5,"class":6},1]