[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100470322":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":33,"responsibleParty":50,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":66,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Banaras Hindu University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Gallbladder Cancer",null,"Patients with confirmed diagnosis of gallbladder cancer",[13],"Diagnostic Test: Next generation sequencing",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Next generation sequencing","NGS is carried out on DNA isolated from paraffin embedded tissue",[9],[21],{"name":22,"affiliation":5,"role":23},"Manoj Pandey, Ms, PhD","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Manoj Pandey, MS, PhD","CONTACT","2361014","mpandey66@bhu.ac.in",{"name":31,"role":27,"phone":28,"phoneExt":10,"email":32},"S K Singh, MD, DM","mdean.ims@gmail.com",[34],{"facility":5,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"RECRUITING","Varanasi","Uttar Pradesh","221005","India","IN",{"type":42,"coordinates":43},"Point",[44,45],83.01041,25.31668,{"lat":45,"lon":44},[48,49],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},{"name":26,"role":27,"phone":10,"phoneExt":10,"email":29},{"type":23,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Manoj Pandey","Professor","100470322","ngs-in-gallbladder-cancer-and-response-to-treatment-100470322",false,"NCT05404347","NGS in Gallbladder Cancer and Response to Treatment","Genetic Mutations and Response to Treatment in Gallbladder Cancer: A Hospital Based Cohort Study","Inclusion Criteria:\n\n* Treatment naïve patients with histologically proven carcinoma of the gallbladder.\n\nExclusion Criteria:\n\n* No histological evidence of malignancy\n* Pregnant and lactating women","ALL","18 Years","99 Years",{"count":64,"type":65},100,"ESTIMATED","5 Years","OBSERVATIONAL","Evidence suggests distinct models of molecular and pathologic progression, and a growing body of genetics data points to a heterogeneous collection of underlying mutations in key oncogenes and tumor suppressor genes. Although tumor genetics have been used to tailor individual treatment regimens and guide clinical decision making in other cancers, these principles have not been applied in gallbladder malignancy. Recent clinical trials with targeted therapies seem promising, although the relationships between subsets of patients with positive responses to therapy and tumor genetics remain unexplored.",[9],"2024-08-09",{"date":72,"type":73},"2024-08-13","ACTUAL",{"date":75,"type":73},"2018-01-01",{"date":77,"type":65},"2026-12-31",{"name":5,"class":6},1]