[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100301592":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":28,"responsibleParty":64,"collaborators":66,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":10,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":10,"studyType":82,"phases":10,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Biological relatives",null,"Biological relatives of probands, who may or may not also be co-enrolled on the proband's referring protocol.",{"label":13,"type":10,"description":14,"interventionNames":10},"Healthy volunteers","Select internal controls",{"label":16,"type":10,"description":17,"interventionNames":10},"Probands","Participants with a disease under investigation by another NIAID protocol on which they are enrolled, either at the NIH or CNHS.",[19],{"name":20,"affiliation":21,"role":22},"Morgan N Similuk","National Institute of Allergy and Infectious Diseases (NIAID)","PRINCIPAL_INVESTIGATOR",[24],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","(301) 435-6691","morgan.similuk@nih.gov",[29,48],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Children's National Health System","RECRUITING","Washington D.C.","District of Columbia","20010","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-77.03637,38.89511,{"lat":41,"lon":40},[44],{"name":45,"role":25,"phone":46,"phoneExt":10,"email":47},"Michael Keller, MD","202-476-5843","mkeller@childrensnational.org",{"facility":49,"status":31,"city":50,"state":51,"zip":52,"country":35,"countryCode":36,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"National Institutes of Health Clinical Center","Bethesda","Maryland","20892",{"type":38,"coordinates":54},[55,56],-77.10026,38.98067,{"lat":56,"lon":55},[59],{"name":60,"role":25,"phone":61,"phoneExt":62,"email":63},"For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)","800-411-1222","TTY dial 711","ccopr@nih.gov",{"type":65,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[67],{"name":68,"class":6},"National Institute of Mental Health (NIMH)","100301592","niaid-centralized-sequencing-protocol-100301592",false,"NCT03206099","NIAID Centralized Sequencing Protocol","* PARTICIPANT INCLUSION CRITERIA:\n* Must fulfill one of the following criteria:\n\n  * Proband participants: must be individuals under investigation by another NIH protocol on which they are co-enrolled, or are referred from the GDMCC protocol \"Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults\" (NCT04702243). Probands may have a disease under investigation or be healthy volunteers\n  * Biological relatives: biologically related to a proband participant.\n* Aged 0-99 years.\n* Participants must be willing to undergo genetic testing.\n* Participants must be willing to allow samples to be stored for future research.\n* Participants must be willing to have their de-identified genomic data shared, for example in a controlled access databases like the Database of Genotypes and Phenotypes (dbGaP).\n* To complete surveys and interviews:\n\n  * Proficient with the English language.\n  * Able to provide informed consent.\n* Adult healthy volunteers must be able to provide informed consent.\n\nPARTICIPANT EXCLUSION CRITERIA:\n\nAny condition that, in the opinion of the investigator, contraindicates participation in this study is a reason for exclusion.",true,"ALL","1 Day","100 Years",{"count":80,"type":81},20000,"ESTIMATED","OBSERVATIONAL","Background:\n\nGenetic testing called \"sequencing\" helps researchers look at DNA. Genes are made of DNA and are the instructions for our bodies to function. We all have thousands of genes. DNA variants are differences in genes between two people. We all have lots of variants. Most are harmless and some cause differences like blue or brown eyes. A few variants can cause health problems.\n\nObjective:\n\nTo understand the genetics of immune disorders various health conditions, as well as outcomes of clinical genomics and genetic counseling services performed under this protocol.\n\nEligibility:\n\nParticipants in other NIH human subjects research protocols - either at the NIH Clinical Center (CC) or at Children s National Health System (CNHS) - (aged 0-99 years), and, in select cases, their biological relatives\n\nDesign:\n\nResearchers will study participant s DNA extracted from blood, saliva, or another tissue sample, including previously collected samples we may have stored at the NIH. Researchers will look at participant s DNA in great detail. We are looking for differences in the DNA sequence or structure between participants and other people.\n\nParticipants will receive results that:\n\n* Are important to their health\n* Have been confirmed in a clinical lab\n* Suggest that they could be at risk for serious disease that may affect your current or future medical management.\n\nSome genetic information we return to participants may be of uncertain importance.\n\nIf genetic test results are unrelated to the participant s NIH evaluations, then we will not typically report:\n\n* Normal variants\n* Information about progressive, fatal conditions that have no effective treatment\n* Carrier status (conditions you don t have but could pass on)\n\nThe samples and data will be saved for future research.\n\nPersonal data will be kept as private as possible.\n\nIf future studies need new information, participants may be contacted.",[85,86,87,88],"Atopy","Primary Immunodeficiency","Autoimmunity","Autoinflammation",[90,91,92,93,94,95],"Phenotyping","Genetics","Sequencing","Inborn Errors of Immunity","Genomics","Natural History","2026-07-01",{"date":98,"type":99},"2026-07-02","ACTUAL",{"date":101,"type":99},"2017-07-31",{"date":103,"type":81},"2029-12-31",{"name":21,"class":6},2]