[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625919":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":62,"collaborators":64,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":26,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":26,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Shaklee Corporation","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Proprietary nutritional supplement","EXPERIMENTAL","Participants will take the experimental supplement orally, daily.",[13],"Dietary Supplement: Proprietary Nutritional Supplement",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo supplement","PLACEBO_COMPARATOR","Participants will take the placebo supplement orally, daily.",[19],"Dietary Supplement: Placebo Supplement",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Proprietary Nutritional Supplement","1000 mg nicotinamide metabolites and plant extracts, taken orally, daily for 60 days",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo Supplement","1000 mg maltodextrin, taken orally, daily for 60 days",[15],[32],{"name":33,"affiliation":5,"role":34},"Erin Barrett, PhD","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Biofortis Research Clinical Director Biofortis Research Clinical Director","CONTACT","(630) 617-2000","biofortisresearch@mxns.com",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Biofortis Clinical Research","RECRUITING","Addison","Illinois","60101","United States","US",{"type":51,"coordinates":52},"Point",[53,54],-87.98896,41.9317,{"lat":54,"lon":53},[57,59],{"name":58,"role":38,"phone":26,"phoneExt":26,"email":40},"Biofortis Research Clinical Director",{"name":60,"role":61,"phone":26,"phoneExt":26,"email":26},"Aditi Shah","PRINCIPAL_INVESTIGATOR",{"type":63,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[65,67],{"name":66,"class":6},"Biofortis Clinical Research, Inc.",{"name":68,"class":6},"Nlumn LLC","100625919","nicotinamide-adenine-dinucleotide-responses-to-a-nutritional-supplement-100625919",false,"NCT07428889","Nicotinamide Adenine Dinucleotide Responses to a Nutritional Supplement","A Randomized, Controlled, Pilot Trial to Assess the Effects of a Proprietary Nutritional Supplement on Nicotinamide Adenine Dinucleotide (NAD+) Responses in Healthy Adults","Inclusion Criteria:\n\n1. Males and females, ≥45 to ≤65 years of age\n2. BMI ≥18.5 and \\\u003C30.0 kg\u002Fm2\n3. Ambulatory and currently free of injury or other physical impairment that hinders mobility.\n4. Willing to use personal smart phone with operating system (Android version 12.0 or newer; iOS version 16 or newer).\n5. Willingness to maintain current skin care regimen and avoid any skin-related medical procedures.\n6. Willing to adhere to all study procedures, including lifestyle considerations and sign forms providing informed consent to participate in the study and authorization to release relevant protected health information to the Clinical Investigator.\n\nExclusion Criteria:\n\n1. Is currently following, or planning to be on, a weight loss regimen.\n2. Weight loss or gain \\>4.5 kg.\n3. History of gastrointestinal surgery for weight reducing purposes.\n4. History of an eating disorder (e.g., anorexia nervosa or bulimia nervosa, binge eating) at the discretion of the Clinical Investigator.\n5. History of neurologic disorder that could produce cognitive deterioration.\n6. History of bouts of delirium, confusion, repeated minor head injury or a single injury.\n7. History of unconventional sleep patterns or a diagnosed sleep disorder.\n8. History of any infective or inflammatory brain disease.\n9. Use of tobacco\u002Fnicotine products.\n10. Use of hemp\u002Fmarijuana products.\n11. Unstable use of any prescription medication.\n12. Unstable use (initiation or change in dose) of hormonal contraceptives or therapy.\n13. Use of any dietary supplements (orally or infused), other than a conventional once daily multi-vitamin.\n14. Use of medication(s) or dietary supplement(s) known to affect absorption.\n15. Recent history of or strong potential for alcohol or substance abuse.\n16. Exposed to any non-registered drug product.\n17. A score of \\\u003C7 on the Vein Access Scale Assessment.\n18. History or presence, on the basis of the medical history or screening labs, of clinically important cardiac, renal, hepatic, endocrine (including diabetes mellitus), pulmonary, gastrointestinal, biliary, pancreatic, or neurological disorders.\n19. Uncontrolled hypertension.\n20. Known allergy to any ingredients contained in the study product.\n21. Any signs or symptoms of active infection of clinical relevance.\n22. History or presence of cancer in the prior 2 years, except for non-melanoma skin cancer.\n23. History of any major trauma or major surgical event.\n24. Female who is pregnant, planning to be pregnant during the study period, lactating, or is of childbearing potential with unstable use of sex hormones for contraception.\n25. An employee or representative who has a financial interest in Sponsor organization.",true,"ALL","45 Years","65 Years",{"count":81,"type":82},34,"ESTIMATED","INTERVENTIONAL",[85],"NA","The objective of this study is to evaluate nicotinamide adenine dinucleotide (NAD+) in response to a proprietary nutritional supplement in generally healthy adults, compared to placebo.",[88],"Healthy Adult",[90,91],"NAD+ metabolism","Markers of health","2026-04-09",{"date":94,"type":95},"2026-04-13","ACTUAL",{"date":97,"type":95},"2026-02-17",{"date":99,"type":82},"2026-06",{"name":5,"class":6},1]