[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100362312":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":35,"locations":45,"responsibleParty":62,"collaborators":30,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":30,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":30,"enrollmentInfo":75,"targetDuration":30,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":30,"overallStatus":48,"whyStopped":30,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Universidad de Murcia","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-incised papillae surgical approach (NIPSA)","EXPERIMENTAL","To access the defect, a single horizontal or oblique apical incision will be made in the mucosa located on the bony cortex, far from the marginal tissues and apically to the edge of the bony crest delimiting the defect. The incision will be extended mesiodistally as necessary to allow access to the defect and correct debridement of the granulation tissue. The tissue coronal to the incision will be raised full thickness, trying to maintain the preoperative papillae architecture intact. The granulation tissue and epithelium of the pocket will be eliminated. The affected root will be scaled and planed, and calculus eliminated. Once the defect will be debrided, the enamel matrix derivates will be applied. Then the incision line will be sutured by a double suture line to facilitate closing without tension: The first with internal horizontal mattress sutures to approximate the connective tissue of both edges of the mucosal incision, and the second with single interrupted sutures.",[13],"Procedure: Non-incised papillae surgical approach (NIPSA)",{"label":15,"type":16,"description":17,"interventionNames":18},"marginal approach by palatal incision","ACTIVE_COMPARATOR","A small incision in the palatal aspect and a limited papila elevation to the buccal aspect will be made for treating isolated periodontal defect. Enamel matrix derivates will be applied on the debrided root surfaces.",[19],"Procedure: marginal approach by palatal incision",{"label":21,"type":16,"description":22,"interventionNames":23},"Minimally invasive surgical technique (MIST)","The incision of the defect-associated papilla will be performed according to the principles of the papilla preservation techniques. Enamel matrix derivates will be applied on the debrided root surfaces. Stable primary closure of the flaps will be obtained with internal modified mattress sutures.",[24],"Procedure: Minimally invasive surgical technique (MIST)",[26,31,33],{"type":27,"name":9,"description":28,"armGroupLabels":29,"otherNames":30},"PROCEDURE","Periodontal reconstructive surgery",[9],null,{"type":27,"name":15,"description":28,"armGroupLabels":32,"otherNames":30},[15],{"type":27,"name":21,"description":28,"armGroupLabels":34,"otherNames":30},[21],[36,41],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},"Antonio J Ortiz-Ruiz, MD","CONTACT","+34 868888581","ajortiz@um.es",{"name":42,"role":38,"phone":43,"phoneExt":30,"email":44},"Jose A Moreno-Rodriguez","+34 620538483","joseantonio171087@hotmail.com",[46],{"facility":47,"status":48,"city":49,"state":30,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"Centro Odontologico Del Sureste Slp","RECRUITING","Murcia","30007","Spain","ES",{"type":54,"coordinates":55},"Point",[56,57],-1.13004,37.98704,{"lat":57,"lon":56},[60,61],{"name":37,"role":38,"phone":39,"phoneExt":30,"email":40},{"name":42,"role":38,"phone":43,"phoneExt":30,"email":44},{"type":63,"investigatorFullName":64,"investigatorTitle":65,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Antonio José Ortiz Ruiz, MD","Professor and researcher","100362312","nipsa-versus-marginal-approach-by-palatal-incision-and-mist-in-periodontal-regeneration-100362312",false,"NCT03997552","NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration","Non-Incised Papillae Surgical Approach (NIPSA) Versus Marginal Approach by Palatal Incision and Minimally Invasive Surgical Technique (MIST) in Periodontal Regeneration: a Ramdomized Clinical Trial","Inclusion Criteria:\n\n* patients diagnosed with periodontitis.\n* plaque index and bleeding index of \\\u003C 30%.\n* periodontal lesions with pocket probing depth \\> 5 mm.\n* intrabony defect \\> 3 mm.\n* intrabony defect configuration including a 1 and\u002For 2-wall component, always involving the buccal wall.\n\nExclusion Criteria:\n\n* patients with systemic diseases that contraindicated treatment.\n* third molars.\n* teeth with incorrect endodontic or restorative treatment.","ALL","18 Years",{"count":76,"type":77},60,"ESTIMATED","INTERVENTIONAL",[80],"NA","Three techniques for periodontal reconstruction will be compared, in which marginal access versus apical access will be carried out.",[83,84,85],"Periodontitis","Periodontal Diseases","Periodontal Pocket","2026-02-16",{"date":88,"type":89},"2026-02-17","ACTUAL",{"date":91,"type":89},"2019-09-06",{"date":93,"type":77},"2027-02-01",{"name":5,"class":6},1]