[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637311":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":25,"responsibleParty":55,"collaborators":57,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":10,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":10,"enrollmentInfo":70,"targetDuration":10,"studyType":73,"phases":10,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Aneurysmal subarachnoid hemorrhage",null,"Patients admitted to the Intensive Care Unit following spontaneous aneurysmal subarachnoid hemorrhage",{"label":13,"type":10,"description":14,"interventionNames":10},"Control","Patients without neurological comorbidities undergoing spinal anesthesia in the operating room",[16],{"name":17,"affiliation":18,"role":19},"Lorenzo Berra, MD","Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital","PRINCIPAL_INVESTIGATOR",[21],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","617-726-3030","lberra@mgh.harvard.edu",[26,41],{"facility":5,"status":27,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":34,"coordinates":35},"Point",[36,37],-71.05977,42.35843,{"lat":37,"lon":36},[40],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},{"facility":42,"status":27,"city":43,"state":10,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":51,"contacts":52},"Fondazione Policlinico Universitario Agostino Gemelli","Rome","00136","Italy","IT",{"type":34,"coordinates":48},[49,50],12.51133,41.89193,{"lat":50,"lon":49},[53],{"name":54,"role":22,"phone":10,"phoneExt":10,"email":10},"Valentina Giammatteo, MD",{"type":19,"investigatorFullName":17,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Lorenzo Berra, MD, Assistant Professor, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School",[58],{"name":59,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","100637311","nitric-oxide-consumption-as-a-predictor-of-vasospasm-in-subarachnoid-hemorrhage-100637311",false,"NCT07614906","Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage","Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage (SAH): a Prospective Observational Study","Inclusion Criteria:\n\n* Adult\n* patient with SAH and with an external ventricular drainage (EVD) placed within 24 hours after the onset of the hemorrhage\n\nExclusion Criteria:\n\n* pregnancy\n* pre-existing neurological comorbidities\n* coagulation disorders\n* anemia\n* absence of a good cranial window to perform Transcranial Doppler (TDC)\n* presence of \\>50% stenosis of carotid arteries confirmed by doppler ultrasound\n* Technical problems on EVD that prevent CSF withdrawals\n\nFor the control group, we will invite to participate patients without neurological comorbidities undergoing spinal anesthesia in the operating room or with a spinal drain for major vascular surgery.",true,"ALL","18 Years",{"count":71,"type":72},40,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH). To reach this goal, the investigators will compare NO consumption levels in SAH and non-SAH patients. NO consumption levels will be analyzed from samples of participants' cerebral spinal fluid (CSF).",[76,77],"Aneurysmal Subarachnoid Hemorrhage","Cerebral Vasospasm",[79],"Nitric Oxide Consumption","2026-05-22",{"date":82,"type":83},"2026-05-29","ACTUAL",{"date":85,"type":83},"2024-03-03",{"date":87,"type":72},"2027-06",{"name":5,"class":6},2]