[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637162":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":11,"locations":21,"responsibleParty":42,"collaborators":10,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":10,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":53,"minAge":54,"maxAge":10,"enrollmentInfo":55,"targetDuration":58,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},{"fullName":5,"class":6},"Carmel Medical Center","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":10},"patient both arms: one operated under brachial plexus block, other serves only as control;",null,[12,17],{"name":13,"role":14,"phone":15,"phoneExt":10,"email":16},"Michael Grach, DR.","CONTACT","+972506265753","Grachm@gmail.com",{"name":18,"role":14,"phone":19,"phoneExt":10,"email":20},"Dana Kosh, Dr.","972-48250785","danak@clalit.org.il",[22],{"facility":23,"status":24,"city":25,"state":10,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"Carmel medical center","RECRUITING","Haifa","3436212","Israel","IL",{"type":30,"coordinates":31},"Point",[32,33],34.99928,32.81303,{"lat":33,"lon":32},[36,39,40],{"name":37,"role":14,"phone":38,"phoneExt":10,"email":16},"Michael Grach, Dr.","972506265753",{"name":18,"role":14,"phone":19,"phoneExt":10,"email":20},{"name":37,"role":41,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":41,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Michael Grach","Dr","100637162","nociception-level-index-after-brachial-plexus-block-in-upper-extremity-surgery-100637162",false,"NCT07620002","Nociception Level Index After Brachial Plexus Block In Upper Extremity Surgery","Nociception Level Index After Brachial Plexus Block In Upper Extremity Surgery: Prospective Comparison Trial","Inclusion Criteria:\n\n* Age \\>18\n* Upper extremity surgery\n* Provision of signed and dated informed consent forms\n\nExclusion Criteria:\n\n* Pregnant women\n* Known allergic reaction to bupivacaine or other anesthetic medicine: Midazolam, Fentanyl, Propofol, Rocuronium, Remifentanil, Sevoflurane)\n* Known coagulopathy resulting in bleeding tendency\n* Thrombocytopenia\n* Abnormal laboratory coagulation tests in the previous week = Anticoagulation therapy Participation in other study",true,"ALL","18 Years",{"count":56,"type":57},45,"ESTIMATED","1 Day","OBSERVATIONAL","The present prospective within-subject observational study will evaluate whether unilateral brachial plexus block (BPB) induces measurable lateralized autonomic modulation, assesses using bilateral Nociception Level (NoL) monitoring during standardized intraoperative stimuli under general anesthesia. Regional anesthesia efficacy is traditionally assessed through sensory and motor examination. However, objective physiologic markers reflecting sympathetic modulation remain limited. Forty five adults undergoing upper extremity surgery with BPB and general anesthesia, bilateral NoL monitoring will be performed during local anesthetic injection, endotracheal intubation, and nasogastric tube placement. The primary aim to investigate whether the brachial plexus block induces unilateral modulation of post-operative nervous system activity, assessed by inter-limb differences in NoL values during predefined nociceptive stimuli under general anesthesia. The secondary aim to evaluate the correlation between postoperative metrics, postoperative pain intensity, and analgesic consumption. From a clinical perspective, bilateral autonomic monitoring may offer a novel adjunctive method for intraoperative confirmation of block activity, particularly in sedated or anesthetized patients where traditional sensory testing is not feasible. Furthermore, inter-limb autonomic gradients could represent a future research pathway for objective assessment of regional anesthesia effectiveness beyond subjective pain scores.",[62],"Brachial Plexus Blockade",[64,65],"brachial plexus block upper extremity","nociception level","2026-05-26",{"date":68,"type":69},"2026-06-02","ACTUAL",{"date":71,"type":69},"2023-03-28",{"date":73,"type":57},"2026-09-30",{"name":5,"class":6},1]