[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524080":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":56,"collaborators":24,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":24,"overallStatus":38,"whyStopped":24,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Attikon Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nociception level index (NOL™)","ACTIVE_COMPARATOR","The nociception level index NOL will be used in order to quide intraopertaive analgesia.",[13],"Device: Nociception level index (NOL™)",{"label":15,"type":10,"description":16,"interventionNames":17},"Standard of care","Intraoperative analgesia will be based on common practice, i.e. changes in hemodynamic parameters.",[18],"Other: Fentanyl",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","If a NOL value \\>25 persists for \\>1 minute a bolus of iv fentanyl 0.5mcg\u002Fkg will be given and reassessment of the NOL value will continue every 5 minutes. If NOL index value: 10-25 is not reached within 10 minutes, fentanyl 0.5mcg\u002Fkg iv is re-administered.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Fentanyl","Bolus doses of iv fentanyl 0.5 mcg\u002Fkg will be administered based on the judgment of the anesthesiologist in charge.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"PARASKEVI Prof MATSOTA","CONTACT","6945544563","matsota@yahoo.gr",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"2nd Department of Anesthesiology, Attikon University Hospital","RECRUITING","Athens","Attica","12462","Greece","GR",{"type":45,"coordinates":46},"Point",[47,48],23.72784,37.98376,{"lat":48,"lon":47},[51,53],{"name":52,"role":32,"phone":24,"phoneExt":24,"email":24},"Paraskevi Matsota, Prof",{"name":54,"role":55,"phone":24,"phoneExt":24,"email":24},"Paraskevi Mastota, MD, PhD","PRINCIPAL_INVESTIGATOR",{"type":55,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Paraskevi Matsota","Prof of Anesthesiology","100524080","nol-guided-analgesia-during-elective-laparoscopic-surgery-under-general-anesthesia-100524080",false,"NCT06104059","NOL Guided Analgesia During Elective Laparoscopic Surgery Under General Anesthesia","Ιntraoperative Administration of Opioids Guided by the Nociception Level Index NOL in Elective Laparoscopic Surgeries Under General Anesthesia: Effect on Opioid Consumption, Post-operative Pain and Patient Recovery","NOLGADELS","Inclusion Criteria:\n\n* Adult patients undergoing planned laparoscopic surgery under general anesthesia.\n\nExclusion Criteria:\n\n* Emergency surgery.\n* Pregnancy.\n* Drug or alcohol abuse in the last 6 months.\n* Chronic opioid use or patients with chronic pain.\n* Serious comorbidity \\[cardiac disease (atrial fibrillation, ventricular arrhythmias), liver or kidney disease\\]\n* Obesity (BMI \\>35).\n* Permanently implanted pacemaker.\n* Patients with CNS disease.\n* Allergy to any of the study drugs.\n* Patients receiving anticholinergics agonists, α2-adrenergic agonists, β1-adrenergic antagonists, antiarrhythmic drugs.","ALL","18 Years","70 Years",{"count":71,"type":72},50,"ESTIMATED","INTERVENTIONAL",[75],"NA","The aim of this study is to investigate the hypothesis that the intraoperative use of the nociception level index NOL can reduce opioid consumption in adult patients undergoing elective laparoscopic surgeries under general anesthesia, as well as to explore its effect on post-operative pain and patient recovery.",[78],"Intraoperative Analgesia","2025-03-30",{"date":81,"type":82},"2025-04-03","ACTUAL",{"date":84,"type":82},"2023-04-20",{"date":86,"type":72},"2026-09-20",{"name":5,"class":6},1]