[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100504020":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":25,"centralContacts":29,"locations":34,"responsibleParty":65,"collaborators":68,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":24,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":24,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":37,"whyStopped":24,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Steno Diabetes Center Copenhagen","OTHER",[8],{"label":9,"type":10,"description":9,"interventionNames":11},"individuals with MASLD","EXPERIMENTAL",[12,13],"Behavioral: Caloric restriction intervention","Other: No intervention",[15,22],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Caloric restriction intervention","The intervention consist of 4-weeks low calories diet (LCD) using total meal replacement from NUPO. A dietician will guide the participants an ensure well-being during the intervention.",[9],[21],"No intervention",{"type":6,"name":21,"description":21,"armGroupLabels":23,"otherNames":24},[9],null,[26],{"name":27,"affiliation":5,"role":28},"Charlotte Brøns, PhD","PRINCIPAL_INVESTIGATOR",[30],{"name":27,"role":31,"phone":32,"phoneExt":24,"email":33},"CONTACT","+4526129093","charlotte.broens.01@regionh.dk",[35,51],{"facility":36,"status":37,"city":38,"state":24,"zip":24,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Steno Diabetes Center Aarhus","RECRUITING","Aarhus","Denmark","DK",{"type":42,"coordinates":43},"Point",[44,45],10.21076,56.15674,{"lat":45,"lon":44},[48],{"name":49,"role":31,"phone":24,"phoneExt":24,"email":50},"Julie Julie Bondgaard Løhde, MD","juliebm@biomed.au.dk",{"facility":5,"status":37,"city":52,"state":24,"zip":24,"country":39,"countryCode":40,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"Herlev",{"type":42,"coordinates":54},[55,56],12.43998,55.72366,{"lat":56,"lon":55},[59,62],{"name":60,"role":31,"phone":61,"phoneExt":24,"email":33},"Charlotte Brøns Brøns, PhD","+45 26129093",{"name":63,"role":31,"phone":24,"phoneExt":24,"email":64},"Allan Vaag Vaag, MD, PhD","allan.arthur.vaag@regionh.dk",{"type":28,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Charlotte Brøns","Principal investigator",[69,71],{"name":70,"class":6},"Aarhus University Hospital",{"name":72,"class":6},"Lund University","100504020","non-alcoholic-fatty-liver-disease-in-low-birth-weight-individuals-100504020",false,"NCT05842850","Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals","Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals - Reversibility and Mechanistic Studies.","Inclusion Criteria:\n\n* subjects with NAFLD (liver fat content ≥5% liver fat content verified on MRS in the screening NAFLD study)\n\nExclusion Criteria:\n\n* BMI\\\u003C18.5 and BMI\\>30 kg\u002Fm2\n* Family history of diabetes (siblings, parent, and grandparents)\n* Disease\u002Fmedication known to affect primary outcome\n* Self-reported high physical activity level\n* Alcohol intake above general recommendations.\n* Metabolic\u002Fliver disease\n* Weight gain\u002Floss of \\>3 kg within the past 6 months","ALL","35 Years","40 Years",{"count":84,"type":85},8,"ESTIMATED","INTERVENTIONAL",[88],"NA","The investigators will conduct a proof-of-principle 4-weeks low-calorie diet (LCD) intervention study in low birth weight (LBW) subjects and normal birth weight (NBW) controls with documented (MR scan) liver fat content equal to or above 5%. The investigators will provide extended in-depth mechanistic insight into the role of impaired subcutaneous adipose tissue (SAT) expandability in ectopic fat deposition before and after LCD.",[91],"NAFLD",[93,94,95,96,97],"Adipose tissue biology","Caloric restriction","Insulin resistance","Energy expenditure","Insulin secretion","2026-04-28",{"date":100,"type":101},"2026-05-04","ACTUAL",{"date":103,"type":101},"2026-01-01",{"date":105,"type":85},"2026-12",{"name":5,"class":6},2]