[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100524805":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":10,"locations":24,"responsibleParty":51,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":10,"overallStatus":27,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of Edinburgh","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"1",null,"50 patients with myocardial infarction and non-obstructive coronary arteries",[13],"Radiation: Hybrid 18F-GP1 positron emission tomography and coronary computed tomography coronary angiography",{"label":15,"type":10,"description":16,"interventionNames":17},"2","10 patients with suspected coronary thromboembolism 10 patients with suspected spontaneous coronary artery dissection 10 patented with iatrogenic spontaneous coronary artery dissection",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"RADIATION","Hybrid 18F-GP1 positron emission tomography and coronary computed tomography coronary angiography","18F-GP1 will be synthesized by our radiochemistry facility, the Edinburgh Imaging Facility Radiochemistry (EIFR), which is co-located within our Edinburgh Imaging Facility, Queens Medical Research Institute (EIF QMRI) using our well-established protocols. Each patient will undergo 18F-GP1 PET\u002FCT coronary angiography imaging on our hybrid scanner (Biograph mCT, Siemens) as soon as practical after their index event and within a maximum of 7 days from symptom onset. Patients will initially be injected with 250 MBq 18F-GP1, before resting in a quiet environment for 60 min. A low-dose attenuation correction CT scan (120 kV, 50 mAs, 5\u002F3 mm) will be followed by acquisition of PET data in list mode using a two 20-min bed position centred on the thoracic aorta and heart. A contrast-enhanced CT coronary angiogram will then be performed.",[9,15],[25],{"facility":26,"status":27,"city":28,"state":10,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Royal Infirmary of Edinburgh","RECRUITING","Edinburgh","EH16 4SA","United Kingdom","UK",{"type":33,"coordinates":34},"Point",[35,36],-3.19648,55.95206,{"lat":36,"lon":35},[39,44,47,48],{"name":40,"role":41,"phone":42,"phoneExt":10,"email":43},"David Ernest Newby, MBChB, PhD","CONTACT","01312426515","D.E.Newby@ed.ac.uk",{"name":45,"role":46,"phone":10,"phoneExt":10,"email":10},"Craig Anthony Balmforth, MBChB","PRINCIPAL_INVESTIGATOR",{"name":40,"role":46,"phone":10,"phoneExt":10,"email":10},{"name":49,"role":50,"phone":10,"phoneExt":10,"email":10},"Marc Dweck, MBChB, PhD","SUB_INVESTIGATOR",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100524805","non-invasive-coronary-thrombus-imaging-to-define-these-cause-of-acute-myocardial-infarction-100524805",false,"NCT06113510","Non-invasive Coronary Thrombus Imaging to Define These Cause of Acute Myocardial Infarction","Non-invasive Coronary Thrombus Imaging to Define the Cause of Acute Myocardial Infarction","Inclusion Criteria:\n\n* Males and females ≥ 18 years of age\n* Clinical presentation of chest pain, ST-segment deviation within a coronary artery territory on the electrocardiogram, raised cardiac troponin and non-obstructive coronary arteries on invasive coronary angiography as per international societal diagnostic criteria\n\nExclusion Criteria:\n\n* \\\u003C18 years of age\n* Takatsubo cardiomyopathy\n* Myocarditis\n* Renal failure (estimated glomerular filtration rate \\\u003C30 mL\u002Fmin\u002F1.73 m2)\n* Woman of child-bearing potential who are pregnant or breastfeeding\n* Known allergy or contraindication to iodinated contrast or radiotracer\n* Patients unable to tolerate the supine position\n* Patients unable to provide informed consent","ALL","18 Years",{"count":63,"type":64},80,"ESTIMATED","OBSERVATIONAL","We now have very sensitive blood tests that can pick up damage to the heart and find patients who have had a heart attack. However, whilst this is welcome, it does not identify what causes the heart attack and can sometimes pick up other conditions that cause a strain on the heart.\n\nThe classic cause of a heart attack is when a blood clot forms on fatty deposits within the heart arteries. This leads to treating patients with blood thinning medication, and this is very effective and saves lives. However, many apparent heart attacks are not caused by blood clots and some may be caused by blood clots but pass unrecognised.\n\nIn this proposal, we will test an exciting new imaging test that can 'see' from outside the body whether there is a blood clot in the heart arteries. This could provide a major new way of assessing patients to ensure they get the right diagnosis and the right treatment. This could ultimately improve the outcomes of or patients with heart attacks.\n\nWe will recruit 80 patients in total who have recently been diagnosed with a heart attack from the cardiology department at the Royal Infirmary of Edinburgh. The research team will review patient's medical records to determine eligibility for the study.\n\nThe research study involves participants undertaking the following research procedures and assessments:\n\n1. A combined Positron Emission Tomography and Computed Tomography (PET-CT) scan of the heart\n2. Ultrasound scan of the heart (Echocardiogram)\n3. MRI scan of the heart\n4. A blood test - a total of up to four tablespoons (60 mL) of blood will be taken for immediate testing and the remaining blood will be stored for future ethically approved studies\n5. A follow up questionnaire 6 -12 months following the heart attack",[68,69],"Myocardial Infarction","Thrombosis","2026-03-13",{"date":72,"type":73},"2026-03-17","ACTUAL",{"date":75,"type":73},"2025-01-06",{"date":77,"type":64},"2028-04-01",{"name":5,"class":6},1]