[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626162":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":21,"centralContacts":26,"locations":10,"responsibleParty":31,"collaborators":10,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":38,"acronym":10,"eligibilityCriteria":39,"healthyVolunteers":36,"sex":40,"minAge":41,"maxAge":42,"enrollmentInfo":43,"targetDuration":10,"studyType":46,"phases":10,"briefSummary":47,"conditions":48,"keywords":50,"overallStatus":55,"whyStopped":10,"lastUpdateSubmitDate":56,"lastUpdatePostDateStruct":57,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":10},{"fullName":5,"class":6},"Peking University People's Hospital","OTHER",[8,13],{"label":9,"type":10,"description":10,"interventionNames":11},"The intervention group received an OLE airway clearance therapy regimen guided by noninvasive monito",null,[12],"Other: Different therapeutic interventions",{"label":14,"type":10,"description":10,"interventionNames":15},"The control group received a conventional airway clearance therapy regimen.",[12],[17],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"Different therapeutic interventions","Eligible patients who met the inclusion and exclusion criteria were randomly assigned to the intervention group and the control group at a 1:1 ratio.\n\nIntervention group: received OLE airway clearance therapy guided by noninvasive monitoring technology.\n\nControl group: received conventional airway clearance therapy, including routine suction via flexible bronchoscopy, etc.",[14,9],[22],{"name":23,"affiliation":24,"role":25},"Shu Li, doctor","Peking University People's Hosptial","PRINCIPAL_INVESTIGATOR",[27],{"name":23,"role":28,"phone":29,"phoneExt":10,"email":30},"CONTACT","+86 010 8832 4480","lishu2401@163.com",{"type":25,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Li Shu","associate professor","100626162","non-invasive-dynamic-monitoring-guided-oscillation-and-lung-expansion-for-airway-clearance-in-severe-blunt-chest-trauma-a-clinical-study-100626162",false,"NCT07432048","Non-Invasive Dynamic Monitoring-Guided Oscillation and Lung Expansion for Airway Clearance in Severe Blunt Chest Trauma: A Clinical Study","Inclusion Criteria:\n\n* Severe blunt chest trauma, defined as injury caused by blunt force such as chest impact or compression, with an Abbreviated Injury Scale (AIS) score of the chest ≥ 3\n* Age 18 to 70 years\n* Time from injury to enrollment \\\u003C 48 hours\n* Receiving invasive mechanical ventilation, with duration of mechanical ventilation \\\u003C 24 hours\n* Written informed consent signed by the patient or his\u002Fher legal representative\n\nExclusion Criteria:\n\n* Combined penetrating chest trauma\n* Perinatal women\n* Inability of the patient to cooperate with examinations and treatment\n* Contraindications to EIT monitoring, including implanted cardiac pacemaker, unhealed local skin wound after thoracic surgery, extensive subcutaneous emphysema of the chest, etc\n* Contraindications to OLE therapy:\n\nHemodynamic instability (heart rate \\\u003C 60 beats\u002Fmin or \\> 130 beats\u002Fmin; systolic blood pressure \\\u003C 90 mmHg or \\> 180 mmHg; or mean arterial pressure \\\u003C 60 mmHg or \\> 100 mmHg)\n\n* Unstable angina pectoris or cardiac arrhythmia\n* Intracranial pressure \\> 20 mmHg\n* Active bleeding\n* Suspected or active hemoptysis\n* Undrained pneumothorax\n* Unstable deep vein thrombosis or pulmonary embolism\n* Unstable spinal or long bone fractures\n* Unstable head and neck injury","ALL","18 Years","70 Years",{"count":44,"type":45},80,"ESTIMATED","OBSERVATIONAL","In our previous study, the investigators analyzed more than 30,000 cases from the National Trauma Center Database and found that 66.4% of patients with severe blunt chest trauma had concurrent rib fractures, 55.87% had multiple fractures (≥4 ribs), and 37.4% had combined pulmonary contusion. In a further prospective observational cohort study evaluating the efficacy of EIT-guided OLE in such patients, results demonstrated that this protocol improved the ventilation-perfusion ratio and oxygenation index and shortened total mechanical ventilation duration. Based on literature review and preliminary findings, the investigators propose the following hypothesis: the application of EIT-noninvasively monitored OLE airway clearance in patients with severe blunt chest trauma can improve the ventilation-perfusion ratio, shorten mechanical ventilation time, reduce the incidence of complications such as pulmonary infection and mortality, and decrease medical resource consumption.\n\nThis study will verify this hypothesis through a prospective randomized controlled trial and further refine the specific implementation protocol of OLE to enhance its scientific validity and clinical applicability.",[49],"Blunt Chest Trauma",[51,52,53,54],"blunt chest trauma","pulmonary contusion","oscillation and lung expansion","electrical Impedance Tomography","NOT_YET_RECRUITING","2026-02-24",{"date":58,"type":59},"2026-02-25","ACTUAL",{"date":61,"type":45},"2026-03",{"date":63,"type":45},"2027-11",{"name":5,"class":6}]