[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100625452":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":25,"locations":25,"responsibleParty":26,"collaborators":25,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":32,"acronym":33,"eligibilityCriteria":34,"healthyVolunteers":35,"sex":36,"minAge":37,"maxAge":25,"enrollmentInfo":38,"targetDuration":25,"studyType":41,"phases":42,"briefSummary":44,"conditions":45,"keywords":25,"overallStatus":47,"whyStopped":25,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":25},{"fullName":5,"class":6},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-invasive coronary flow reserve in patients with ANOCA","EXPERIMENTAL","We will enroll patients referred to the catheterization laboratory of the Fondazione Policlinico Universitario A. Gemelli IRCCS for stable angina who showed non-obstructive coronary arteries at coronary angiography and underwent invasive coronary functional tests (adenosine and\u002For acetylcholine test).",[13],"Diagnostic Test: Coronary flow reserve assessed by Echocardiography",{"label":15,"type":16,"description":17,"interventionNames":18},"Non-invasive coronary flow reserve in healthy volunteers","ACTIVE_COMPARATOR","To confirm the reliability of possible abnormal results of non-invasive coronary functional tests in angina and non-obstructive coronary arteries (ANOCA) patients, we will enroll healthy control subjects of similar age and gender of enrolled patients, selected among those referred to our ambulatory of clinical visits for a routine cardiological evaluation and undergo a screening stress test for coronary artery disease. They will undergo a dipyridamole stress echocardiogram, which is commonly used in clinical practice to investigate the presence of coronary artery disease.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","Coronary flow reserve assessed by Echocardiography","All patients and controls will undergo the following tests during transthoracic echocardiographic Doppler examination of the left anterior descending coronary artery, with time intervals of 30 minutes from each other:\n\n1. hyperventilation test: the patient is asked to breathe at a rate of 30 respirations per minute, for 5 minutes;\n2. cold pressor test: the patient puts his\u002Fher right hand in ice water for 2 minutes;\n3. dipyridamole test: intravenous dipyridamole is administered at a dose of 0.84 mg\u002Fkg over 6 minutes; Peak diastolic velocity (PDV) of blood flow in the left anterior descending coronary artery will be measured before and at the end of each test by pulsed-wave Doppler, using a GE E95 echocardiographic machine.\n\nThe ratio between peak flow velocity of coronary blood flow at peak of each test and the relative basal peak flow velocity of coronary blood flow is taken as the response of coronary blood flow velocity to each test.",[15,9],null,{"type":27,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100625452","non-invasive-evaluation-of-patients-with-angina-and-non-obstructive-coronary-artery-disease-100625452",false,"NCT07422818","Non-invasive Evaluation of Patients With Angina and Non-obstructive Coronary Artery Disease","NEO-NOCAD","Inclusion Criteria:\n\n1. Age between 18 and 90 years;\n2. ICA performed within the previous 12 months from enrollment and characterized by: (a) absence of obstructive CAD (\\<50% diameter reduction or FFR by \\>0.80); (b) invasive assessment of epicardial\u002Fmicrovascular spasm by acetylcholine test;\n3. Signed informed consent.\n\nExclusion Criteria:\n\n1. Presentation as an acute coronary syndrome (i.e. unstable chest pain) or a typical history of variant angina (frequent angina pain at rest with ST-segment elevation at the ECG, caused by recurrent coronary spasm);\n2. Previous coronary revascularization with surgical intervention;\n3. Asthma or known intolerance or contraindications to dipyridamole;\n4. Serious medical conditions, including renal failure (eGFR \\<30 mL\u002Fmin), liver diseases, malignancies, and acute or chronic inflammatory diseases;\n5. Pregnancy;\n6. Psychological conditions that might hamper patient co-operation;\n7. Any condition that, in the judgment of the investigators, would make difficult for the patient to complete the study protocol;\n8. Missed informed consent.",true,"ALL","18 Years",{"count":39,"type":40},35,"ESTIMATED","INTERVENTIONAL",[43],"NA","This is a single-center, prospective interventional study evaluating noninvasive coronary function testing using transthoracic Doppler echocardiography of the left anterior descending coronary artery in patients with stable angina and nonobstructive coronary artery disease (ANOCA) who previously underwent invasive coronary function testing (adenosine and\u002For acetylcholine).\n\nA group of age- and sex-matched healthy volunteers will be enrolled to support interpretation of potentially abnormal noninvasive responses observed in patients.",[46],"ANOCA - Angina With Non-obstructive Coronary Arteries","NOT_YET_RECRUITING","2026-02-13",{"date":50,"type":51},"2026-02-20","ACTUAL",{"date":53,"type":40},"2026-03",{"date":55,"type":40},"2026-11",{"name":5,"class":6}]