[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560064":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":30,"responsibleParty":47,"collaborators":19,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":19,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":19,"maxAge":19,"enrollmentInfo":58,"targetDuration":19,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":33,"whyStopped":19,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Southeast University, China","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"PNS group","EXPERIMENTAL","Electrical stimulation of the phrenic nerve in ARDS patients.",[13],"Device: PNS group",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","non-invasive phrenic nerve stimulation",[9],null,[21],{"name":22,"affiliation":23,"role":24},"ling liu, phD","Zhongda Hospital","PRINCIPAL_INVESTIGATOR",[26],{"name":22,"role":27,"phone":28,"phoneExt":19,"email":29},"CONTACT","15901599659","18826401594@163.com",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Zhongda Hospital, School of Medicine, Southeast University","RECRUITING","Nanjing","Jiangsu","210009","China","CN",{"type":40,"coordinates":41},"Point",[42,43],118.77778,32.06167,{"lat":43,"lon":42},[46],{"name":22,"role":27,"phone":28,"phoneExt":19,"email":29},{"type":24,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Ling Liu","Director of Intensive Care Unit, Principal Investigator, Clinical Professor","100560064","non-invasive-phrenic-nerve-stimulation-in-ards-patient-100560064",false,"NCT06572280","Non-invasive Phrenic Nerve Stimulation in ARDS Patient","Non-invasive Phrenic Nerve Stimulation in ARDS Patients - a Feasibility Study","Inclusion Criteria:\n\n1. Adult ARDS patients undergoing controlled mechanical ventilation\n2. The duration of endotracheal intubation \\\u003C 48 hrs\n\nExclusion Criteria:\n\n1. Neurological condition affecting motor neuron or muscle (e.g. ALS)\n2. Paralysis of the phrenic nerve\n3. Proven or suspected spinal cord injury\n4. Conditions that limit diaphragm movement\n5. Patients with Implanted cardiac support systems (pacemaker, implanted defibrillator)\n6. Patients with implanted medical pumps\n7. Pregnancy\n8. Patients with skin lesions, infections or strictures in throat\u002Fneck area\n9. Patients with metallic implants\n10. Refusal to sign informed consent","ALL",{"count":59,"type":60},10,"ESTIMATED","INTERVENTIONAL",[63],"NA","Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment. This, in turn, may prolong the duration of mechanical ventilation, make weaning more difficult, and even increase mortality. Synchronizing phrenic nerve stimulation to promote diaphragmatic activity may prevent ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, thereby improving patient outcomes. Surgically implanted phrenic nerve stimulation has been used in certain neurological disorders, but the effects of percutaneous non-invasive synchronized phrenic nerve stimulation in patients with ARDS undergoing mechanical ventilation remain unclear and require further investigation.",[66,67,68],"ARDS, Human","Ventilator-Induced Lung Injury","Diaphragm Injury",[70,71,72],"ARDS","diaphragm injury","mechanical ventilation","2024-08-25",{"date":75,"type":76},"2024-08-27","ACTUAL",{"date":78,"type":76},"2024-08-01",{"date":80,"type":60},"2025-01-30",{"name":5,"class":6},1]