[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636070":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":30,"centralContacts":39,"locations":45,"responsibleParty":64,"collaborators":30,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":30,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":30,"overallStatus":48,"whyStopped":30,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Masaryk University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"20 Hz striatal stimulation","EXPERIMENTAL","Striatum will be targeted by using two pairs of high-frequency tES with a low-frequency offset (20 Hz), creating an interference hotspot targeting the deep brain structure (deep-tES).",[13],"Other: Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (20 Hz)",{"label":15,"type":10,"description":16,"interventionNames":17},"60 Hz striatal stimulation","Striatum will be targeted by using two pairs of high-frequency tES with a low-frequency offset (60 Hz), creating an interference hotspot targeting the deep brain structure (deep-tES).",[18],"Other: Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (60 Hz)",{"label":20,"type":21,"description":22,"interventionNames":23},"Sham striatal stimulation","SHAM_COMPARATOR","Striatum will be targeted by using two pairs of high-frequency tES with no low-frequency offset. The stimulation will be applied only shortly and turned off after ramp-up and ramp-down period.",[24],"Other: Control striatal stimulation",[26,31,35],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (20 Hz)","Striatum will be targeted by using at least two pairs of high-frequency tES with a low-frequency (20 Hz) offset, creating an interference hotspot targeting the deep brain structure (deep-tES).",[9],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Control striatal stimulation","A high-frequency tES without low-frequency offset. It will consist of two oscillatory high-frequency currents without any frequency shifts, which induces similar skin sensations as deep-tES and will be applied just for a ramp-up\u002Framp-down phases at the beginning of the stimulation and afterwards will be switched off.",[20],{"type":6,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (60 Hz)","Striatum will be targeted by using at least two pairs of high-frequency tES with a low-frequency (60 Hz) offset, creating an interference hotspot targeting the deep brain structure (deep-tES).",[15],[40],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Monika Pupíková","CONTACT","+420549498818","monika.pupikova@ceitec.muni.cz",[46],{"facility":47,"status":48,"city":49,"state":30,"zip":50,"country":51,"countryCode":30,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"CEITEC Masaryk University","RECRUITING","Brno","612 00","Czechia",{"type":53,"coordinates":54},"Point",[55,56],16.60796,49.19522,{"lat":56,"lon":55},[59,60,62],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},{"name":30,"role":42,"phone":30,"phoneExt":30,"email":61},"pupikovam@gmail.com",{"name":41,"role":63,"phone":30,"phoneExt":30,"email":30},"SUB_INVESTIGATOR",{"type":65,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Monika Pupikova","prof. Irena Rektorová MD, Ph.D.","100636070","non-invasive-stimulation-of-deep-brain-structures-to-modulate-working-memory-100636070",false,"NCT07560904","Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory","DEEPBRAIN","Inclusion Criteria:\n\n* normal cognitive performance as assessed by a cognitive screening for healthy subjects\n* possible or probable MCI-LB or with PD-MCI, collectively called MCI-LBD, described as: presence of PD , and level II criteria for MCI (i.e. based on comprehensive neuropsychological examination), or the level II criteria for MCI , and at least two of four core DLB features including parkinsonism, visual hallucinations, attention\u002Fcognitive function fluctuation, and REM sleep behavioral disorder, or at least 1 core clinical feature and 1 indicative biomarker (probable MCI-LB).\n\nExclusion Criteria:\n\n* Psychiatric disorders including major depression, major vascular lesions, or other brain pathologies that might present with cognitive decline.",true,"ALL","60 Years","80 Years",{"count":80,"type":81},70,"ESTIMATED","INTERVENTIONAL",[84],"NA","A study investigating the effects of non-invasive electrical stimulation of deep brain structures on working memory, attention, and executive functions involved in everyday activities. Currently, there is no effective treatment for impairments in these functions. The study will evaluate the effects of non-invasive electrical stimulation in both healthy older adults and individuals with mild impairment of these functions.\n\nThe study combines magnetic resonance imaging (MRI) with non-invasive brain stimulation targeting deep brain structures. Its aim is to improve understanding of the neural mechanisms underlying these cognitive functions and their impairments, as well as to explore the mechanisms of non-invasive brain stimulation for potential future therapeutic applications.",[87,88],"Older Adults (60 - 85 Years Old)","Mild Cognitive Impairment (MCI)","2026-04-28",{"date":91,"type":92},"2026-05-01","ACTUAL",{"date":94,"type":92},"2026-03-01",{"date":96,"type":81},"2026-07",{"name":5,"class":6},1]