[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100477627":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":28,"locations":34,"responsibleParty":47,"collaborators":27,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":51,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":27,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":27,"overallStatus":69,"whyStopped":27,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"active stimulus group","ACTIVE_COMPARATOR","Patients were assigned into active stimulus group according to random number table",[13],"Device: Transcranial low intensity focused ultrasound stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"sham stimulus control group","SHAM_COMPARATOR","Patients were assigned into sham stimulus control group according to random number table",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Transcranial low intensity focused ultrasound stimulation","Low intensity focused transcranial ultrasound stimulation can safely and effectively regulate neuron excitability through mechanical force.",[9,15],[26],"tFUS",null,[29],{"name":30,"role":31,"phone":32,"phoneExt":27,"email":33},"Penghu Wei, doctor","CONTACT","18601986863","weipenghu@xwhosp.org",[35],{"facility":36,"status":27,"city":37,"state":27,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":27},"Xuanwu Hospital, Capital Medical University.","Beijing","100053","China","CN",{"type":42,"coordinates":43},"Point",[44,45],116.39723,39.9075,{"lat":45,"lon":44},{"type":48,"investigatorFullName":27,"investigatorTitle":27,"investigatorAffiliation":27,"oldNameTitle":27,"oldOrganization":27},"SPONSOR","100477627","non-invasive-transcranial-focused-low-intensity-ultrasound-stimulation-in-patients-with-mild-lewy-body-dementia-100477627",false,"NCT05499429","Non-invasive Transcranial Focused Low-intensity Ultrasound Stimulation in Patients With Mild Lewy Body Dementia","Clinical Single-center Randomized Controlled Trial of Non-invasive Transcranial Focused Low-intensity Ultrasound Stimulation in Patients With Mild Lewy Body Dementia","tFUS in DLB","Inclusion Criteria:\n\n* Male or female DLB patients between the ages of 50-85;\n* The psychological evaluation was in accordance with MMSE score of 18-24 (including 18 and 24) and CDR score of 0.5.\n* Can cooperate to complete clinical research.\n\nExclusion Criteria:\n\n* There is a definite history of cerebrovascular stroke, and there are definite symptoms or signs of neurological deficit at the time of onset, and there are corresponding responsible lesions left by neuroimaging。\n* Those who have a history of alcoholism, or drug addiction, or neurological diseases such as brain trauma, epilepsy, encephalitis, normal intracranial pressure hydrocephalus, etc. that can cause cognitive impairment.\n* Suffering from systemic diseases that may lead to cognitive impairment (such as liver and kidney insufficiency, endocrine diseases, vitamin deficiency).\n* Have a history of using antipsychotics for more than five years before diagnosis.\n* There are contraindications for head MRI examination.","ALL","50 Years","85 Years",{"count":61,"type":62},20,"ESTIMATED","INTERVENTIONAL",[65],"NA","A randomized controlled clinical study was conducted in the xuanwu hospital Single Center of Capital Medical University to preliminarily explore the efficacy and safety of transcranial focused low-intensity ultrasound stimulation in the treatment of dementia with Lewy bodies in the early stage, to clarify the effective mechanism and form an effective clinical treatment plan.",[68],"Lewy Body Dementia","NOT_YET_RECRUITING","2022-08-10",{"date":72,"type":73},"2022-08-12","ACTUAL",{"date":75,"type":62},"2022-09",{"date":77,"type":62},"2026-11",{"name":5,"class":6},1]