[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100509500":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":20,"responsibleParty":30,"collaborators":20,"id":33,"slug":34,"hasResults":35,"nctId":36,"briefTitle":37,"officialTitle":38,"acronym":20,"eligibilityCriteria":39,"healthyVolunteers":35,"sex":40,"minAge":41,"maxAge":20,"enrollmentInfo":42,"targetDuration":20,"studyType":45,"phases":46,"briefSummary":48,"conditions":49,"keywords":53,"overallStatus":57,"whyStopped":20,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":20},{"fullName":5,"class":6},"University of Southern California","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Single","EXPERIMENTAL","Stimulation of the ultrasound retinal stimulation Device",[13],"Device: Non-invasive ultrasound retinal stimulation Device",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Non-invasive ultrasound retinal stimulation Device","Record user feelings during the device is working",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Qifa Zhou, PhD","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":20,"email":29},"CONTACT","(213) 821-2649","qifazhou@usc.edu",{"type":24,"investigatorFullName":31,"investigatorTitle":32,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Qifa Zhou","Professor","100509500","non-invasive-ultrasound-retinal-stimulation-for-vision-restoration-100509500",false,"NCT05914233","Non-invasive Ultrasound Retinal Stimulation for Vision Restoration","Revolutionary Non-Invasive Ultrasound Technology for Vision Restoration in Age-Related Macular Degeneration (AMD) and Retinitis Pigmentosa (RP) Patients","Inclusion Criteria:\n\n1. Diagnosis of AMD (regardless of stage and type) or RP. At least two volunteers should diagnose with RP.\n2. Age 18 years or older\n3. No other eye-related health conditions\n4. No allergic history to commercial ultrasound gel\n5. Must be willing and able to comply with the protocol testing\n\nExclusion Criteria:\n\n1. Declining to participate and inability to give informed consent.\n2. Unable to comply with the process of the research\n3. If the volunteer has optic nerve disease, including the history of glaucoma, optic neuropathy, or other confirmed damage to optic nerve or visual cortex damage\n4. Unable to fixate that hinders obtaining high-quality imaging\n5. High myopia; refractive error of six diopters and above\n6. Pregnancy\n7. Subject is participating in another investigational drug or device study that may conflict with the objectives, follow-up, or testing of this study","ALL","18 Years",{"count":43,"type":44},5,"ESTIMATED","INTERVENTIONAL",[47],"NA","This clinical trial aims to test the safety and feasibility of using a non-invasive ultrasound device to stimulate retinal nerve cells and restore vision in patients with age-related macular degeneration. Previous studies have shown that artificial stimulation, such as electric and optic stimulations, can partially restore vision, but these methods are invasive and pose surgical risks. The study aims to develop a non-invasive method for retinal stimulation. The investigators will follow the FDA guidelines to limit the ultrasound power and adhere to all clinical trial regulations to ensure all participants' safety.\n\nThe main questions the investigators aim to answer are:\n\n* Is using high-frequency ultrasound safe using a wearable device for localized retinal neural activity stimulation?\n* Does the stimulation through the device restore vision in patients with age-related macular degeneration?\n\nParticipants in this study will be asked to undergo Optical Coherence Tomography (OCT) scanning before and after the ultrasound stimulation to evaluate the device's safety. Then, they will receive five stimulation-rest cycles and complete a questionnaire to report what they see and how they feel during the device's operation.",[50,51,52],"Age-Related Macular Degeneration","Retinitis Pigmentosa","Ultrasound Therapy; Complications",[54,55,56,50],"Ultrasound Stimulation","Retinal","Retinitis pigmentosa","NOT_YET_RECRUITING","2026-01-06",{"date":60,"type":61},"2026-01-08","ACTUAL",{"date":63,"type":44},"2027-01-10",{"date":65,"type":44},"2028-07-15",{"name":5,"class":6}]