[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577885":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":38,"locations":43,"responsibleParty":57,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Temple University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Stimulation","EXPERIMENTAL","Participants in the active arm will receive a 2-min transcutaneous vagus nerve stimulation using a portable hand-held digital wellness Truvaga Plus device by placing it on the anterolateral cervical area of the neck.",[13],"Device: Active nVNS",{"label":15,"type":10,"description":16,"interventionNames":17},"Control Stimulation","Participants in the control arm will receive a 2-min transcutaneous stimulation using a portable hand-held digital wellness Truvaga Plus device by placing it on the posterolateral part of the neck (near the overlapping area between the trapezeus muscle and the shoulder).",[18],"Device: Control nVNS",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Active nVNS","2-min transcutaneous nVNS stimulation using portable Truvaga Plus Device (electroCore Inc., Rockaway, NJ).",[9],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Control nVNS","2-min control stimulation using portable Truvaga Plus Device (electroCore Inc., Rockaway, NJ).",[15],[31,34,36],{"name":32,"affiliation":5,"role":33},"Vinay Parikh, PhD","PRINCIPAL_INVESTIGATOR",{"name":35,"affiliation":5,"role":33},"Jason Chein, PhD",{"name":37,"affiliation":5,"role":33},"Tania Giovannetti, PhD",[39],{"name":32,"role":40,"phone":41,"phoneExt":25,"email":42},"CONTACT","215-204-1572","vinay.parikh@temple.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":25},"RECRUITING","Philadelphia","Pennsylvania","19122","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-75.16362,39.95238,{"lat":55,"lon":54},{"type":58,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100577885","non-invasive-vagus-nerve-stimulation-nvns-and-cognition-in-young-adult-vapers---a-pilot-study-100577885",false,"NCT06804109","Non-invasive Vagus Nerve Stimulation (nVNS) and Cognition in Young Adult Vapers - A Pilot Study","Vaping and Vagal Neuromodulation of Cognition","nVNS","Inclusion Criteria:\n\n* Healthy young adults\n* Age range 18-25 years\n* Current or prior users of e-cigarettes\n\nExclusion Criteria:\n\nParticipants will be excluded from the study if they:\n\n* Have any rash, infection, swelling, cut, soreness, drug patch, surgical scar on the neck area\n* Have any implantable medical device in their body such as a pacemaker, hearing aid implant, or any other metallic\u002Felectronic device\n* Have any hearing or vision problems that are not corrected\n* Are pregnant or breastfeeding\n* Have any learning disabilities\n* Have a medical history of any of the following condition\n* Meningitis\n* Traumatic brain injury\n* Seizure\n* Syncope\n* Schizophrenia\n* Schizoaffective disorder\n* Bulimia (eating disorder)\n* Other serious neurological illness\n* Have a medical history of any of the following cardiac disorder\n\n  * Carotid atherosclerosis or carotid artery disease\n  * Cervical vagotomy\n  * First degree atrioventricular block or prolonged QT interval\n* Are taking any medications for to treat hypertension, arrhythmias, or are on calcium channel blockers",true,"ALL","18 Years","25 Years",{"count":72,"type":73},100,"ESTIMATED","INTERVENTIONAL",[76],"NA","The purpose of this study is to assess the effects of non-invasive vagus nerve stimulation (nNVS) on cognitive functioning in the users of e-cigarettes or vaping products. The investigators will use a digital wellness companion product (TRUVAGA™ device) that provides mild transcutaneous nVNS. The participants will be randomized to receive either a 2-min nNVS stimulation or control stimulation in the neck region followed by completion of three cognitive tests of attention and executive function.",[79],"Vaping",[81,82,83],"vaping","attention","non-invasive vagus nerve stimulation","2026-03-05",{"date":86,"type":87},"2026-03-06","ACTUAL",{"date":89,"type":87},"2025-03-18",{"date":91,"type":73},"2028-02-09",{"name":5,"class":6},1]