[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100592700":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":34,"centralContacts":40,"locations":46,"responsibleParty":72,"collaborators":44,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":44,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":44,"enrollmentInfo":84,"targetDuration":44,"studyType":87,"phases":88,"briefSummary":90,"conditions":91,"keywords":94,"overallStatus":49,"whyStopped":44,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-Invasive Ventilation (NIV)","EXPERIMENTAL","Intervention:\n\nParticipants in this arm will receive non-invasive ventilation using bilevel positive airway pressure (BiPAP) delivered via a full-face mask to support ventilation in patients with acute hypoxemic respiratory failure due to community-acquired pneumonia (CAP).",[13],"Device: Non-Invasive ventilation (NIV)",{"label":15,"type":10,"description":16,"interventionNames":17},"High velocity nasal insufflation (HVNI)","Intervention:\n\nParticipants in this arm will receive high-velocity nasal insufflation therapy, a type of high-flow nasal cannula (HFNC) therapy that delivers heated and humidified oxygen at high flow rates to support patients with acute hypoxemic respiratory failure resulting from community-acquired pneumonia (CAP).",[18],"Device: High Velocity Nasal Insufflation",[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Non-Invasive ventilation (NIV)","Participants in this arm will receive noninvasive ventilation using bilevel positive airway pressure (BiPAP) delivered via a full-face mask to support ventilation in patients with acute hypoxemic respiratory failure due to CAP.",[9],[26],"BI-level Positive airway pressure ventilation (BIPAP)",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"High Velocity Nasal Insufflation","Participants in this arm will receive high-velocity nasal insufflation therapy, a type of high-flow nasal cannula (HFNC) therapy that delivers heated and humidified oxygen at high flow rates to support patients with acute hypoxemic respiratory failure resulting from community-acquired pneumonia (CAP).",[15],[32,33],"High velocity nasal cannula","Vapotherm delivery system",[35,38],{"name":36,"affiliation":5,"role":37},"Ahmad M. Shaddad, MD","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":5,"role":37},"Aliae A. Hussien, MD",[41],{"name":36,"role":42,"phone":43,"phoneExt":44,"email":45},"CONTACT","+0201111171930",null,"shaddad_ahmad@yahoo.com",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"Assuit University","RECRUITING","Asyut","Assuit","71515","Egypt","EG",{"type":56,"coordinates":57},"Point",[58,59],31.18368,27.18096,{"lat":59,"lon":58},[62,64,65,67,70],{"name":36,"role":42,"phone":63,"phoneExt":44,"email":45},"+201111171930",{"name":36,"role":37,"phone":44,"phoneExt":44,"email":44},{"name":66,"role":37,"phone":44,"phoneExt":44,"email":44},"Aliae M. Hussien, MD",{"name":68,"role":69,"phone":44,"phoneExt":44,"email":44},"Amal A. Abdullah, MD","SUB_INVESTIGATOR",{"name":71,"role":69,"phone":44,"phoneExt":44,"email":44},"Ahmad M. Abd El-hafeez, MD",{"type":37,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"Ahmad Shaddad","Associate professor","100592700","noninvasive-support-methods-for-acute-respiratory-failure-of-community-acquired-pneumonia-100592700",false,"NCT06996834","Noninvasive Support Methods for Acute Respiratory Failure of Community-acquired Pneumonia","A Randomized Controlled Trial of High-Velocity Nasal Insufflation (HVNI) Versus Noninvasive Ventilation (NIV) for Acute Respiratory Failure of Community-Acquired Pneumonia (CAP).","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Clinical and radiographic diagnosis of CAP\n* Respiratory failure using partial pressure of oxygen (PaO₂) and fraction of inspired oxygen (FiO₂) is defined by a partial pressure of oxygen\u002Ffraction of inspired oxygen ratio (PaO₂\u002FFiO₂) ≤ 300 mmHg or a respiratory rate (RR) ≥ 25\u002Fmin\n* Informed consent obtained\n\nExclusion Criteria:\n\n* Hemodynamic instability requiring vasopressors\n* Altered mental status Glasgow Coma Scale (GCS \\\u003C 13)\n* Contraindication to NIV or HVNI (facial trauma, recent upper airway surgery)\n* Do-Not-Intubate (DNI) order","ALL","18 Years",{"count":85,"type":86},100,"ESTIMATED","INTERVENTIONAL",[89],"NA","This randomized controlled trial aims to compare the efficacy and safety of high-velocity nasal insufflation (HVNI) versus standard noninvasive ventilation (NIV) in adult patients experiencing acute exacerbations of community-acquired pneumonia (CAP) accompanied by hypoxemic respiratory failure. The primary focus is on assessing treatment failure within 48 hours, defined as the need for intubation or death. Secondary outcomes include evaluations of gas exchange parameters, patient comfort levels, duration of ICU stay, and 28-day mortality rates.",[92,93],"Community-acquired Pneumonia","Community-Acquired Infections",[95,96,97],"CAP","NIV","HVNI","2026-04-26",{"date":100,"type":101},"2026-04-30","ACTUAL",{"date":103,"type":101},"2025-07-01",{"date":105,"type":86},"2026-11-01",{"name":5,"class":6},1]