[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607832":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":330,"collaborators":332,"id":336,"slug":337,"hasResults":338,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":338,"sex":344,"minAge":345,"maxAge":24,"enrollmentInfo":346,"targetDuration":24,"studyType":349,"phases":350,"briefSummary":352,"conditions":353,"keywords":355,"overallStatus":37,"whyStopped":24,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":363,"completionDateStruct":364,"leadSponsor":366,"locationsCount":367},{"fullName":5,"class":6},"Hospital Universitari Vall d'Hebron Research Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard care: elective delivery at 37 weeks of gestation","ACTIVE_COMPARATOR","In the control group, a blood test to assess the sFlt-1\u002FPlGF ratio will be performed, and the result will be concealed from investigators. As in current clinical practice, elective delivery will be scheduled at 37 weeks. If preeclampsia is first diagnosed after 37 weeks, immediate delivery will be recommended. If at any time after enrollment any of the following is present, immediate delivery (within 24 hours) will be recommended: preeclampsia with severe features according to ACOG criteria, decreased fetal movements, absent or reversed diastolic flow in the umbilical artery, non-reassuring CTG, biophysical profile score ≤6, or oligohydramnios.",[13],"Other: Standard care: elective delivery at 37 weeks of gestation",{"label":15,"type":16,"description":17,"interventionNames":18},"Intervention arm: expectant management if sFlt-1\u002FPlGF\u003C38","EXPERIMENTAL","If sFlt-1\u002FPlGF \\\u003C38, expectant management will be followed until 39 weeks. If any other medical condition is present, local protocols for the specific condition will be followed. If fetal growth restriction in present (with antegrade diastolic umbilical flow), weekly repetition of sFlt-1\u002FPlGF wil be done. If sFlt-1\u002FPlGF ≥38, delivery at 37 weeks will be recommended, or immediate delivery if the patient is enrolled after 37 weeks. If at any time after enrollment any of the following is present, immediate delivery (within 24 hours) will be recommended: preeclampsia with severe features according to ACOG criteria, decreased fetal movements, absent or reversed diastolic flow in the umbilical artery, non-reassuring CTG, biophysical profile score ≤6, sFlt-1\u002FPlGF ≥38 or oligohydramnios.",[19],"Other: Intervention arm: expectant management if sFlt-1\u002FPlGF\u003C38",[21,25],{"type":6,"name":15,"description":22,"armGroupLabels":23,"otherNames":24},"If the angiogenic factors are normal (sFlt-1\u002FPlGF \\\u003C38), expectant management will be followed until 39 weeks, instead of delivery at ≥37 weeks of gestation as in standard care for preeclampsia without severe features.",[15],null,{"type":6,"name":9,"description":26,"armGroupLabels":27,"otherNames":24},"In the control arm, standard care for preeclampsia without severe features will be followed: elective delivery at ≥37 weeks of gestation.",[9],[29],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Erika Bonacina, MD, PhD","CONTACT","003493 489 30 00","erika.bonacina@vallhebron.cat",[35,54,67,80,89,102,115,128,141,154,167,180,193,206,219,232,245,258,268,281,294,304,317],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Hospital Universitari Dexeus","RECRUITING","Barcelona","BARCELONA","08024","Spain","ES",{"type":44,"coordinates":45},"Point",[46,47],2.15899,41.38879,{"lat":47,"lon":46},[50],{"name":51,"role":31,"phone":52,"phoneExt":24,"email":53},"Raquel Mula","+3493 227 47 47","raqmul@dexeus.com",{"facility":55,"status":37,"city":56,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":57,"geoPoint":61,"contacts":62},"Hospital Universitario de A Coruña","A 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Elche","Elche",{"type":44,"coordinates":119},[120,121],-0.70107,38.26218,{"lat":121,"lon":120},[124],{"name":125,"role":31,"phone":126,"phoneExt":24,"email":127},"Claudia Rodriguez","+34966 616 900","clau.rodmon@gmail.com",{"facility":129,"status":37,"city":130,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":131,"geoPoint":135,"contacts":136},"Hospital Universitario de Getafe","Getafe",{"type":44,"coordinates":132},[133,134],-3.73295,40.30571,{"lat":134,"lon":133},[137],{"name":138,"role":31,"phone":139,"phoneExt":24,"email":140},"Elena Pintado","+3491 683 93 60","elenapintadoparedes@gmail.com",{"facility":142,"status":37,"city":143,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":144,"geoPoint":148,"contacts":149},"Hospital Universitari de Girona Doctor Josep Trueta","Girona",{"type":44,"coordinates":145},[146,147],2.82493,41.98311,{"lat":147,"lon":146},[150],{"name":151,"role":31,"phone":152,"phoneExt":24,"email":153},"Anna Maroto","+34972 94 02 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Herraiz","+3491 390 80 00","ignacio.herraiz@salud.madrid.org",{"facility":220,"status":37,"city":221,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":222,"geoPoint":226,"contacts":227},"Hospital Clínico Universitario Virgen de la Arrixaca","Murcia",{"type":44,"coordinates":223},[224,225],-1.13004,37.98704,{"lat":225,"lon":224},[228],{"name":229,"role":31,"phone":230,"phoneExt":24,"email":231},"Marisa Sanchez","+34968 36 95 00","marisa00111@hotmail.com",{"facility":233,"status":37,"city":234,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":235,"geoPoint":239,"contacts":240},"Hospital Universitari Son Espases","Palma de Mallorca",{"type":44,"coordinates":236},[237,238],2.65024,39.56939,{"lat":238,"lon":237},[241],{"name":242,"role":31,"phone":243,"phoneExt":24,"email":244},"Maria Vila","+34871 20 50 0","mariavilacortes@gmail.com",{"facility":246,"status":37,"city":247,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":248,"geoPoint":252,"contacts":253},"Hospital Universitario Virgen de Valme","Seville",{"type":44,"coordinates":249},[250,251],-5.97317,37.38283,{"lat":251,"lon":250},[254],{"name":255,"role":31,"phone":256,"phoneExt":24,"email":257},"Carlota Borrero","+34955 01 50 00","carlotaborrero@gmail.com",{"facility":259,"status":37,"city":247,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":260,"geoPoint":262,"contacts":263},"Hospital Universitario Virgen Macarena",{"type":44,"coordinates":261},[250,251],{"lat":251,"lon":250},[264],{"name":265,"role":31,"phone":266,"phoneExt":24,"email":267},"Isabel Fontan","+34955 00 80 00","imfontanatal@gmail.com",{"facility":269,"status":37,"city":270,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":271,"geoPoint":275,"contacts":276},"Hospital Universitari de Tarragona Joan XXIII","Tarragona",{"type":44,"coordinates":272},[273,274],1.24544,41.11905,{"lat":274,"lon":273},[277],{"name":278,"role":31,"phone":279,"phoneExt":280,"email":279},"Monica Lopez","monicalopez4099@gmail.com","+34977 29 58 0",{"facility":282,"status":37,"city":283,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":284,"geoPoint":288,"contacts":289},"Consorci Sanitari de Terrassa","Terrassa",{"type":44,"coordinates":285},[286,287],2.01667,41.56667,{"lat":287,"lon":286},[290],{"name":291,"role":31,"phone":292,"phoneExt":24,"email":293},"Esperanza Garcia","+3493 731 00 07","egcancela@me.com",{"facility":295,"status":37,"city":283,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":296,"geoPoint":298,"contacts":299},"Hospital Universitari MútuaTerrassa",{"type":44,"coordinates":297},[286,287],{"lat":287,"lon":286},[300],{"name":301,"role":31,"phone":302,"phoneExt":24,"email":303},"Eva Lopez","+3493 736 50 50","evalq@hotmail.com",{"facility":305,"status":37,"city":306,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":307,"geoPoint":311,"contacts":312},"Hospital Universitario de Torrejón","Torrejón",{"type":44,"coordinates":308},[309,310],-1.2,40.25,{"lat":310,"lon":309},[313],{"name":314,"role":31,"phone":315,"phoneExt":24,"email":316},"Raquel Martin","+3491 626 26 00","raqmaral@gmail.com",{"facility":318,"status":37,"city":319,"state":24,"zip":24,"country":41,"countryCode":42,"cosmosGeoPoint":320,"geoPoint":324,"contacts":325},"Hospital Universitario Lozano Blesa","Zaragoza",{"type":44,"coordinates":321},[322,323],-0.87734,41.65606,{"lat":323,"lon":322},[326],{"name":327,"role":31,"phone":328,"phoneExt":24,"email":329},"Daniel Oros","+34976 76 57 00","danoros@gmail.com",{"type":331,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR",[333],{"name":334,"class":335},"Instituto de Salud Carlos III","OTHER_GOV","100607832","nope37-angiogenic-factors-for-managing-term-preeclampsia-100607832",false,"NCT07193680","NOPE37: Angiogenic Factors for Managing Term Preeclampsia","Angiogenic Markers for Confirming Term Preeclampsia (noPE-37 Trial): An Open-Label, Randomized Controlled Trial","NOPE37","Inclusion Criteria:\n\n* Age ≥18 years\n* Singleton pregnancy\n* Preeclampsia without severe features according to the ACOG definition\n* Antegrade diastolic flow in the umbilical artery Doppler\n* Gestational age between 36+0 and 38+6 weeks of gestation\n* Gestational age confirmed by fetal crown-rump length measurement in the first-trimester scan (from 11+0 to 13+6 weeks of gestation) or by in vitro fertilization dates\n\nExclusion Criteria:\n\n* Fetal death\n* Preeclampsia with severe features according to the ACOG definition, eclampsia, or any condition that requires immediate delivery\n* Absent or reversed end-diastolic flow in the umbilical artery Doppler\n* Non-reassuring CTG\n* Decreased fetal movements\n* Biophysical profile score ≤6\n* Oligohydramnios\n* Refusal to provide informed consent\n* Fetal malformation\n* Placental abruption\n* Antiphospholipid antibody syndrome","FEMALE","18 Years",{"count":347,"type":348},750,"ESTIMATED","INTERVENTIONAL",[351],"NA","This study tests the hypothesis that, in women with preeclampsia without severe features, delivery management based on sFlt-1\u002FPlGF would reduce the rate of induction of labor without worsening the rate of progression to preeclampsia with severe features and other maternal complications.",[354],"Preeclampsia",[356,357,358],"preeclampsia","angiogenic factors","expectant management","2025-12-04",{"date":361,"type":362},"2025-12-11","ACTUAL",{"date":359,"type":362},{"date":365,"type":348},"2028-04",{"name":5,"class":6},23]