[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642011":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":26,"centralContacts":27,"locations":33,"responsibleParty":48,"collaborators":26,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":26,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":26,"enrollmentInfo":61,"targetDuration":26,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":36,"whyStopped":26,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Hitit University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Normal Tidal Volume Ventilation","ACTIVE_COMPARATOR","Participants in this group will receive standard mechanical ventilation after induction of general anesthesia and endotracheal intubation during retrograde intrarenal surgery. Tidal volume will be set at 6-8 mL\u002Fkg predicted body weight with 5 cmH₂O PEEP. Respiratory rate will be titrated to maintain EtCO₂ between 35 and 45 mmHg, and FiO₂ will be adjusted to maintain SpO₂ above 94%.",[13],"Procedure: low tidal volume ventilation",{"label":15,"type":16,"description":17,"interventionNames":18},"Low Tidal Volume Ventilation","EXPERIMENTAL","Participants in this group will receive low tidal volume mechanical ventilation after induction of general anesthesia and endotracheal intubation during retrograde intrarenal surgery. Tidal volume will be set at 4-6 mL\u002Fkg predicted body weight with 5 cmH₂O PEEP. Respiratory rate will be titrated to maintain EtCO₂ between 35 and 45 mmHg, and FiO₂ will be adjusted to maintain SpO₂ above 94%.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","low tidal volume ventilation","Participants allocated to the normal tidal volume ventilation group will receive volume-controlled mechanical ventilation during retrograde intrarenal surgery under general anesthesia. Tidal volume will be set at 6-8 mL\u002Fkg predicted body weight with 5 cmH₂O PEEP. Respiratory rate will be titrated to maintain EtCO₂ between 35 and 45 mmHg, and FiO₂ will be adjusted to maintain SpO₂ above 94%.",[15,9],[9],null,[28],{"name":29,"role":30,"phone":31,"phoneExt":26,"email":32},"Sibel Onen Ozdemir, MD","CONTACT","+905442892194","sibelonen89@gmail.com",[34],{"facility":35,"status":36,"city":37,"state":26,"zip":26,"country":38,"countryCode":26,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Hitit university","RECRUITING","Çorum","Turkey (Türkiye)",{"type":40,"coordinates":41},"Point",[42,43],34.95333,40.54889,{"lat":43,"lon":42},[46],{"name":47,"role":30,"phone":26,"phoneExt":26,"email":26},"Ozgur Yagan, Professor",{"type":49,"investigatorFullName":50,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Sibel Onen Ozdemir","Medical Doctor","100642011","normal-vs-low-tidal-volume-ventilation-in-retrograde-intrarenal-surgery-100642011",false,"NCT07643324","Normal vs Low Tidal Volume Ventilation in Retrograde Intrarenal Surgery","Comparison of Normal Ventilation and Low Tidal Volume Ventilation During Retrograde Intrarenal Surgery (RIRS) Using Video-Based Motion Index: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Patients scheduled for elective retrograde intrarenal surgery under general anesthesia\n* ASA physical status I-III\n* Patients who are able to read and understand the informed consent form\n* Patients who provide written informed consent\n\nExclusion Criteria:\n\n* Patients younger than 18 years\n* Pregnancy\n* Emergency surgery\n* Severe chronic obstructive pulmonary disease, severe restrictive pulmonary disease, or preoperative hypercapnia\n* Severe uncontrolled cardiovascular disease\n* Active urinary tract infection, sepsis, or untreated infectious focus\n* Cases in whom the standardized ventilation protocol is difficult to apply because of morbid obesity\n* Patients scheduled for an additional major urological procedure in the same session\n* Cases in which an intraoperative video recording of sufficient quality cannot be obtained\n* Patients in whom the study protocol cannot be safely continued according to the investigator's clinical judgment","ALL","18 Years",{"count":62,"type":63},60,"ESTIMATED","INTERVENTIONAL",[66],"NA","Retrograde intrarenal surgery is commonly performed under general anesthesia for the treatment of renal stones. During the procedure, respiratory-related renal movement caused by positive-pressure ventilation may impair endoscopic image stability and reduce the efficiency of laser lithotripsy. This randomized controlled trial aims to compare the effects of normal ventilation and low tidal volume ventilation on intraoperative endoscopic image stability during RIRS using a video-based Motion Index.\n\nEligible adult patients scheduled for elective RIRS under general anesthesia will be randomized in a 1:1 ratio to either normal tidal volume ventilation or low tidal volume ventilation. A standardized 60-second intraoperative video segment in which the stone and\u002For active laser lithotripsy is visible will be analyzed by blinded assessors. The primary outcome is the mean Motion Index value calculated from sequential video frames. Secondary outcomes include additional Motion Index parameters, laser activation time, anesthesia and surgical duration, intraoperative respiratory and hemodynamic safety parameters, vasopressor requirement, complications, and stone-free status at routine follow-up.",[69],"Renal Calculi",[71,72,73,74,75],"General anesthesia","Retrograde intrarenal surgery","Low tidal volume ventilation","Video-based image analysis","Endoscopic visualization quality","2026-06-19",{"date":78,"type":79},"2026-06-23","ACTUAL",{"date":81,"type":79},"2026-04-29",{"date":83,"type":63},"2026-09-01",{"name":5,"class":6},1]