[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100522910":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":53,"collaborators":20,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":20,"eligibilityCriteria":61,"healthyVolunteers":58,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":20,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":20,"overallStatus":30,"whyStopped":20,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Liver Transplantation with Steatotic Liver","EXPERIMENTAL","Graft will be selected if 30-60% macrosteatosis and transplanted into liver transplant recipient with MELD of 15-25.",[13],"Device: Normothermic machine perfusion (NMP) of steatotic liver",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DEVICE","Normothermic machine perfusion (NMP) of steatotic liver","Steatotic liver grafts that are selected will be run on NMP to assess quality of graft and determine whether it meets criteria for transplantation",[9],null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Heidi Yeh, MD","CONTACT","617-643-4533","hyeh@mgh.harvard.edu",[28],{"facility":29,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"Massachusetts General Brigham","RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-71.05977,42.35843,{"lat":40,"lon":39},[43,47,51],{"name":44,"role":24,"phone":45,"phoneExt":20,"email":46},"Olivia Bourgeois, CRC II, BS","617-724-1976","obourgeois@mgb.org",{"name":48,"role":24,"phone":49,"phoneExt":20,"email":50},"Emily Nyhan, CRC II, MS","617-643-6266","enyhan@mgb.org",{"name":23,"role":52,"phone":20,"phoneExt":20,"email":20},"PRINCIPAL_INVESTIGATOR",{"type":52,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"Heidi Yeh","Principal Investigator","100522910","normothermic-machine-perfusion-of-steatotic-livers-for-expansion-of-donor-organ-pool-100522910",false,"NCT06088758","Normothermic Machine Perfusion of Steatotic Livers for Expansion of Donor Organ Pool","Inclusion Criteria:\n\n* Age 18-80 years\n* Listed for liver transplantation at MGH\n* Calculated MELD-Na score \\\u003C= 25\n* Able to consent\n\nExclusion Criteria:\n\n* Status 1a\n* Cardiac or pulmonary disease\n* Prior liver transplant\n* Requiring pressors at the time of liver offer\n* MELD\\\u003C15 and asymptomatic from liver disease","ALL","18 Years","80 Years",{"count":66,"type":67},200,"ESTIMATED","INTERVENTIONAL",[70],"NA","The goal of this clinical trial is to assess the ability of Normothermic Machine Perfusion (NMP) to resuscitate moderately steatotic livers for transplantation in patients. This will be a single-site clinical trial placing donor livers with 30-60% macrosteatosis on NMP, and then transplanting those that meet commonly accepted viability criteria. The results of this study could lead to a trial extending NMP transplantation to severely steatotic livers, further expanding the donor organ pool.",[73],"Liver Transplant","2025-10-31",{"date":76,"type":77},"2025-11-03","ACTUAL",{"date":79,"type":77},"2024-02-28",{"date":81,"type":67},"2027-07-31",{"name":5,"class":6},1]